Isocudraniaxanthone A | CAS:197447-26-0

Isocudraniaxanthone A

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Description:

Isocudraniaxanthone A may have antimalarial activity.

Targets:

Antifection

In vitro:

Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1615-9.

Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis.[Pubmed: 9353889]

Through bioassay-guided separation of the methanol extracts of Indonesian medicinal plants, three inhibitors of the Na+/H+ exchange system, erythrinin B (2), euchrenone b10 (3), and 1,3,5-trihydroxy-4-(3-methylbut-2-enyl)xanthen-9-one (4), were isolated from the bark of Erythrina variegata (Fabaceae) (for 2) and the roots of Maclura cochinchinensis (Moraceae) (for 2, 3, 4).
METHODS AND RESULTS:
Compounds 2, 3, and 4 significantly inhibited the Na+/H+ exchange system of arterial smooth muscle cells, with minimum inhibitory concentrations of 1.25, 1.25, and 10 micrograms/ml, respectively. Three new prenylated xanthones named isocudraniaxanthone B (5) and Isocudraniaxanthone A (7) and isoalvaxanthone (9) were also isolated from M. cochinchinensis and the chemical structures were elucidated on the bases of their chemical and physicochemical properties.

Isocudraniaxanthone A Description

Source:	The roots of Maclura cochinchinensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Life Sci. 2004 Nov 5;75(25):3077-85.

Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii.[Pubmed: 15474559 ]

The antimalarial activity of 22 xanthones against chloroquino-resistant strains of Plasmodium falciparum was evaluated.
METHODS AND RESULTS:
Natural caloxanthone C (1), demethylcalabaxanthone (2), calothwaitesixanthone (3), calozeyloxanthone (4), dombakinaxanthone (5), macluraxanthone (6), and 6-deoxy-gamma-mangostin (7) were isolated from Calophyllum caledonicum. 1,6-dihydroxyxanthone (8), pancixanthone A (9), isocudraniaxanthone B (10), Isocudraniaxanthone A (11), 2-deprenylrheediaxanthone B (12) and 1,4,5-trihydroxyxanthone (13) were isolated from Garcinia vieillardii. Moreover, synthetic compounds (14-22) are analogues or intermediates of xanthones purified from Calophyllum caledonicum (Oger J.M., Morel C., Helesbeux J.J., Litaudon M., Seraphin D., Dartiguelongue C., Larcher G., Richomme P., Duval O. 2003. First 2-Hydroxy-3-Methylbut-3-Enyl substituted xanthones isolated from Plants: structure elucidation, synthesis and antifungal activity. Natural Product Research 17(3), 195-199; Helesbeux J.J., Duval O., Dartiguelongue C., Seraphin D., Oger J.M., Richomme P., 2004. Synthesis of 2-hydroxy-3-methylbut-3-enyl substituted coumarins and xanthones as natural products. Application of the Schenck ene reaction of singlet oxygen with ortho-prenylphenol precursors. Tetrahedron 60(10), 2293-2300). The relationship between antimalarial activity and molecular structure of xanthones has also been explored.
CONCLUSIONS:
The most potent xanthones (2), (3) and (7) (IC50 = c.a. 1.0 microg/mL) are 1,3,7 trioxygenated and prenylated on the positions 2 and 8.

Product Name	Isocudraniaxanthone A
Price:
CAS No.:	197447-26-0
Catalog No.:	CFN89134
Molecular Formula:	C₁₈H₁₆O₆
Molecular Weight:	328.32 g/mol
Purity:	>=98%
Type of Compound:	Xanthones
Physical Desc.:	Powder
Source:	The roots of Maclura cochinchinensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antimalaric Compound Library Xanthones Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0458 mL	15.229 mL	30.4581 mL	60.9162 mL	76.1452 mL
5 mM	0.6092 mL	3.0458 mL	6.0916 mL	12.1832 mL	15.229 mL
10 mM	0.3046 mL	1.5229 mL	3.0458 mL	6.0916 mL	7.6145 mL
50 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.2183 mL	1.5229 mL
100 mM	0.0305 mL	0.1523 mL	0.3046 mL	0.6092 mL	0.7615 mL

CFN91524	Garcixanthones B	2522597-99-3	380.4	C₂₃H₂₄O₅
CFN98427	8-Deoxygartanin	33390-41-9	380.4	C₂₃H₂₄O₅
CFN98428	Gartanin	33390-42-0	396.4	C₂₃H₂₄O₆
CFN92942	Xanthone V1a	103450-96-0	396.43	C₂₃H₂₄O₆
CFN89085	Pancixanthone A	174232-30-5	312.32	C₁₈H₁₆O₅
CFN89134	Isocudraniaxanthone A	197447-26-0	328.32	C₁₈H₁₆O₆
CFN96577	Isocudraniaxanthone B	199851-52-0	342.35	C₁₉H₁₈O₆
CFN97410	Cudraxanthone B	84955-05-5	394.4	C₂₃H₂₂O₆
CFN89371	Cudratricusxanthone A	740810-42-8	396.43	C₂₃H₂₄O₆
CFN97543	Cudraxanthone D	96552-41-9	410.5	C₂₄H₂₆O₆