Tetrahydroalstonine | CAS:6474-90-4 | Manufacturer ChemFaces

Tetrahydroalstonine

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Product Name	Tetrahydroalstonine
Price:	$338 / 5mg
CAS No.:	6474-90-4
Catalog No.:	CFN97109
Molecular Formula:	C₂₁H₂₄N₂O₃
Molecular Weight:	352.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Solid
Source:	The herbs of Uncaria rhynchophylla (Miq.) Miq. ex Havil.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $227.8 / In-stock
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Description:

Tetrahydroalstonine and Raubasine preferentially block the pressor responses of post-synaptic alpha-adrenergic receptor activation due to exogenous and endogenouse noradrenaline, respectively.

Targets:

Adrenergic Receptor

In vivo:

J Pharmacol. 1985 Oct-Dec;16(4):412-20.

Differential inhibition of raubasine and tetrahydroalstonine on the vasopressor response to sympathetic nervous stimulation and intravenous noradrenaline in the pithed rat[Pubmed: 2869187]

The effects of raubasine and Tetrahydroalstonine (THA) on the vasopressor response to sympathetic nerve stimulation and to i.v. administration of noradrenaline were studied in the pithed rat to ascertain whether raubasine and THA would preferentially block pressor responses due to exogenous versus endogenous noradrenaline alpha-adrenergic receptor activation.
METHODS AND RESULTS:
Raubasine (0.5 to 4 mg/kg i.v.) was more effective in blocking the response due to sympathetic nerve stimulation than that due to i.v. noradrenaline. On the other hand THA (0.5 to 4 mg/kg i.v.) produced greater inhibition of the i.v. noradrenaline response than the sympathetic nerve stimulation response. THA (0.5, 1, 2 mg/kg i.v.) enhanced the nerve stimulation response, while at the 4 mg/kg dose the response was slightly reduced. This may be explained by a preferential block by THA at low doses, of presynaptic alpha 2-adrenoceptors. In pithed rat raubasine and THA showed dose-related blocking effects on the pressor response of phenylephrine and B-HT 933, respectively. This suggest that raubasine preferentially blocks alpha-1 and THA alpha 2-adrenoceptors.
CONCLUSIONS:
The results suggest that raubasine and THA preferentially block the pressor responses of post-synaptic alpha-adrenergic receptor activation due to endogenous and exogenous noradrenaline, respectively.

Tetrahydroalstonine Description

Source:	The herbs of Uncaria rhynchophylla (Miq.) Miq. ex Havil.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Eur J Pharmacol. 1984 Oct 30;106(1):203-5.

Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine.[Pubmed: 6099269]

METHODS AND RESULTS:
The relative potencies of raubasine, Tetrahydroalstonine (THA) and akuammigine on alpha 1- and alpha 2-adrenoceptors were assessed by comparing their effects on the rise in blood pressure induced by stimulation of the sympathetic outflow from the spinal cord or by injection of noradrenaline in pithed rats. Akuammigine was inactive in both cases. Raubasine preferentially antagonized the effects of electrical stimulation while Tetrahydroalstonine antagonized the effects of injected noradrenaline.
CONCLUSIONS:
The results suggest that raubasine preferentially blocks alpha 1-adrenoceptors while Tetrahydroalstonine is more selective for alpha 2-adrenoceptors.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Alkaloids Compound Library Adrenergic Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8377 mL	14.1884 mL	28.3768 mL	56.7537 mL	70.9421 mL
5 mM	0.5675 mL	2.8377 mL	5.6754 mL	11.3507 mL	14.1884 mL
10 mM	0.2838 mL	1.4188 mL	2.8377 mL	5.6754 mL	7.0942 mL
50 mM	0.0568 mL	0.2838 mL	0.5675 mL	1.1351 mL	1.4188 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	0.5675 mL	0.7094 mL

CFN96746	Rauvotetraphylline E	1422506-53-3	335.4	C₂₀H₁₉N₂O₃
CFN97709	Alstonine	642-18-2	349.4	C₂₁H₂₁N₂O₃
CFN97710	Akuammigine	642-17-1	352.43	C₂₁H₂₄N₂O₃
CFN97721	Serpentinic acid	605-14-1	335.38	C₂₀H₁₉N₂O₃
CFN98283	Mayumbine	25532-45-0	352.4	C₂₁H₂₄N₂O₃
CFN98499	Serpentinine	36519-42-3	684.8	C₄₂H₄₄N₄O₅
CFN98652	4,R-ajmalicine N-oxide	41590-29-8	368.4	C₂₁H₂₄N₂O₄
CFN98760	Aricine	482-91-7	382.5	C₂₂H₂₆N₂O₄
CFN98761	Ajmalicine	483-04-5	352.4	C₂₁H₂₄N₂O₃
CFN99867	Serpentine	18786-24-8	349.4	C₂₁H₂₁N₂O₃