Isocudraniaxanthone B | CAS:199851-52-0

Isocudraniaxanthone B

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Description:

Isocudraniaxanthone B may have antimalarial activity.

Targets:

Sodium Channel | Antifection

In vitro:

Chem Pharm Bull (Tokyo). 1997 Oct;45(10):1615-9.

Indonesian medicinal plants. XXI. Inhibitors of Na+/H+ exchanger from the bark of Erythrina variegata and the roots of Maclura cochinchinensis.[Pubmed: 9353889]

Through bioassay-guided separation of the methanol extracts of Indonesian medicinal plants, three inhibitors of the Na+/H+ exchange system, erythrinin B (2), euchrenone b10 (3), and 1,3,5-trihydroxy-4-(3-methylbut-2-enyl)xanthen-9-one (4), were isolated from the bark of Erythrina variegata (Fabaceae) (for 2) and the roots of Maclura cochinchinensis (Moraceae) (for 2, 3, 4).
METHODS AND RESULTS:
Compounds 2, 3, and 4 significantly inhibited the Na+/H+ exchange system of arterial smooth muscle cells, with minimum inhibitory concentrations of 1.25, 1.25, and 10 micrograms/ml, respectively. Three new prenylated xanthones named Isocudraniaxanthone B (5) and isocudraniaxanthone A (7) and isoalvaxanthone (9) were also isolated from M. cochinchinensis and the chemical structures were elucidated on the bases of their chemical and physicochemical properties.

Isocudraniaxanthone B Description

Source:	The roots of Maclura cochinchinensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Life Sci. 2004 Nov 5;75(25):3077-85.

Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii.[Pubmed: 15474559 ]

The antimalarial activity of 22 xanthones against chloroquino-resistant strains of Plasmodium falciparum was evaluated.
METHODS AND RESULTS:
Natural caloxanthone C (1), demethylcalabaxanthone (2), calothwaitesixanthone (3), calozeyloxanthone (4), dombakinaxanthone (5), macluraxanthone (6), and 6-deoxy-gamma-mangostin (7) were isolated from Calophyllum caledonicum. 1,6-dihydroxyxanthone (8), pancixanthone A (9), Isocudraniaxanthone B (10), isocudraniaxanthone A (11), 2-deprenylrheediaxanthone B (12) and 1,4,5-trihydroxyxanthone (13) were isolated from Garcinia vieillardii. Moreover, synthetic compounds (14-22) are analogues or intermediates of xanthones purified from Calophyllum caledonicum (Oger J.M., Morel C., Helesbeux J.J., Litaudon M., Seraphin D., Dartiguelongue C., Larcher G., Richomme P., Duval O. 2003. First 2-Hydroxy-3-Methylbut-3-Enyl substituted xanthones isolated from Plants: structure elucidation, synthesis and antifungal activity. Natural Product Research 17(3), 195-199; Helesbeux J.J., Duval O., Dartiguelongue C., Seraphin D., Oger J.M., Richomme P., 2004. Synthesis of 2-hydroxy-3-methylbut-3-enyl substituted coumarins and xanthones as natural products. Application of the Schenck ene reaction of singlet oxygen with ortho-prenylphenol precursors. Tetrahedron 60(10), 2293-2300). The relationship between antimalarial activity and molecular structure of xanthones has also been explored.
CONCLUSIONS:
The most potent xanthones (2), (3) and (7) (IC50 = c.a. 1.0 microg/mL) are 1,3,7 trioxygenated and prenylated on the positions 2 and 8.

Product Name	Isocudraniaxanthone B
Price:
CAS No.:	199851-52-0
Catalog No.:	CFN96577
Molecular Formula:	C₁₉H₁₈O₆
Molecular Weight:	342.35 g/mol
Purity:	>=98%
Type of Compound:	Xanthones
Physical Desc.:	Powder
Source:	The roots of Maclura cochinchinensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antimalaric Compound Library Xanthones Compound Library Sodium Channel Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.921 mL	14.6049 mL	29.2099 mL	58.4197 mL	73.0247 mL
5 mM	0.5842 mL	2.921 mL	5.842 mL	11.6839 mL	14.6049 mL
10 mM	0.2921 mL	1.4605 mL	2.921 mL	5.842 mL	7.3025 mL
50 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.1684 mL	1.4605 mL
100 mM	0.0292 mL	0.146 mL	0.2921 mL	0.5842 mL	0.7302 mL

CFN97260	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone	776325-66-7	396.4	C₂₃H₂₄O₆
CFN89050	Formoxanthone A	869880-32-0	394.42	C₂₃H₂₂O₆
CFN97424	Nigrolineaxanthone V	864516-31-4	408.5	C₂₄H₂₄O₆
CFN89129	Parvifolixanthone B	906794-57-8	410.46	C₂₄H₂₆O₆
CFN95152	New Compound 1	N/A	296.3	C₁₈H₁₆O₄
CFN91524	Garcixanthones B	2522597-99-3	380.4	C₂₃H₂₄O₅
CFN98427	8-Deoxygartanin	33390-41-9	380.4	C₂₃H₂₄O₅
CFN98428	Gartanin	33390-42-0	396.4	C₂₃H₂₄O₆
CFN92942	Xanthone V1a	103450-96-0	396.43	C₂₃H₂₄O₆
CFN89085	Pancixanthone A	174232-30-5	312.32	C₁₈H₁₆O₅