Methyl ganoderate A | CAS:105742-78-7 | Manufacturer ChemFaces

Methyl ganoderate A

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Size /Price /Stock	10 mM * 1 mL in DMSO / $475.0 / In-stock
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Methyl ganoderate A Description

Source:	The fruit body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Planta Med . 1998 May;64(4):303-308.

Natural inhibitors for protein prenyltransferase[Pubmed: 9619109]

Farnesyl protein transferase (FPT) catalyzes the posttranslational farnesylation of the cysteine residue located in the carboxyl-terminal tetrapeptide of the Ras oncoprotein. Prenylation of this residue is essential for membrane association and cell transforming activities of Ras. Inhibitors of FPT have been demonstrated to inhibit Ras-dependent cell transformation and thus represent a potential therapeutic strategy for the treatment of human cancers (1). In the present study, the inhibitory principles for protein prenyltransferases were isolated and identified from Ganoderma lucidum and garlic. The inhibitors from Ganoderma lucidum were identified as ganoderic acid A and ganoderic acid C by comparison with the reported spectral data. Ganoderic acid A has an IC50 value of 100 microM against FPT and its methyl ester (Methyl ganoderate A) has an IC50 value of 38 microM for the same enzyme. These inhibitors appear to be competitive with farnesyl pyrophosphate (FPP), and Ki values of ganoderic acid A and Methyl ganoderate A are 54 microM and 20 microM, respectively. The inhibitors from garlic were identified as diallyl thiosulfinate (allicin), methyl allyl thiosulfinate, and allyl methyl thiosulfinate. These inhibitors are more effective against geranylgeranyl protein transferase (GGPT) than FPT and IC50 values of allicin, methyl allyl thiosulfinate, and allyl methyl thiosulfinate for GGPT were 43 microM, 57 microM, and 53 microM, respectively. Methyl allyl thiosulfinate appears to be competitive with geranylgeranyl pyrophosphate (GGPP) and its Ki was determined to be 15 microM. The molecular structures of triterpenes and thiosulfinates are expected to be useful in designing lead compounds for new potent antitumour agents.

Product Name	Methyl ganoderate A
Price:	$413 / 5mg
CAS No.:	105742-78-7
Catalog No.:	CFN95550
Molecular Formula:	C₃₁H₄₆O₇
Molecular Weight:	530.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The fruit body of Ganoderma lucidum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8843 mL	9.4215 mL	18.843 mL	37.6861 mL	47.1076 mL
5 mM	0.3769 mL	1.8843 mL	3.7686 mL	7.5372 mL	9.4215 mL
10 mM	0.1884 mL	0.9422 mL	1.8843 mL	3.7686 mL	4.7108 mL
50 mM	0.0377 mL	0.1884 mL	0.3769 mL	0.7537 mL	0.9422 mL
100 mM	0.0188 mL	0.0942 mL	0.1884 mL	0.3769 mL	0.4711 mL

CFN91921	12-Hydroxyganoderic acid D	942950-96-1	530.65	C₃₀H₄₂O₈
CFN95535	12-Acetoxy ganoderic acid D	N/A	572.7	C₃₂H₄₄O₉
CFN90747	Ganoderic acid M	100761-17-9	530.7	C₃₀H₄₂O₈
CFN90295	Ganoderic acid Z	294674-09-2	514.66	C₃₀H₄₂O₇
CFN90296	Ganoderic acid AM1	149507-55-1	514.66	C₃₀H₄₂O₇
CFN92576	Ethyl ganoderate J	1189555-95-0	542.7	C₃₂H₄₆O₇
CFN95582	Methyl ganoderate E	98718-43-5	526.7	C₃₁H₄₂O₇
CFN95526	Hainanic acid B	1637737-46-2	514.7	C₃₀H₄₂O₇
CFN95527	New compound 18	N/A	516.7	C₃₀H₄₄O₇
CFN95545	New compound 20	N/A	514.7	C₃₀H₄₂O₇