Isomorellinol | CAS:149655-53-8 | Manufacturer ChemFaces

Isomorellinol

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Description:

Isomorellinol induces apoptosis in cholangiocarcinoma (CCA)cells which is mediated through a mitochondria-dependent signaling pathway.

In vitro:

World J Gastroenterol. 2010 May 14;16(18):2235-43.

Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines.[Pubmed: 20458760 ]

To investigate the growth inhibitory mechanism of four caged xanthones from Garcinia hanburyi in cholangiocarcinoma (CCA) KKU-100 and KKU-M156 cells.
METHODS AND RESULTS:
Four caged xanthones, selected on the basis of their anticancer potency and chemical structure diversities (i.e. isomorellin, Isomorellinol, forbesione and gambogic acid) were used in this study. Growth inhibition of these caged xanthones was determined using the sulforhodamine B assay. Induction of apoptosis was assessed by observing cell morphology, ethidium bromide and acridine orange staining and DNA fragmentation assay. Levels of apoptotic-related gene and protein expressions were determined by a real-time reverse transcriptase polymerase chain reaction and Western blotting analysis, respectively.
CONCLUSIONS:
Our findings for the first time demonstrate that four caged xanthones induce apoptosis in CCA cells which is mediated through a mitochondria-dependent signaling pathway.

Isomorellinol Description

Source:	The herbs of Garcinia hanburyi Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Anal Chim Acta. 2008 Nov 23;629(1-2):104-18.

Analysis of caged xanthones from the resin of Garcinia hanburyi using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry.[Pubmed: 18940327 ]

On-line ultra high-performance liquid chromatography (UHPLC) coupled with electrospray quadrupole time-of-flight tandem mass spectrometry (ESI-QTOF-MS/MS/MS) has been developed for the analysis of a series of caged xanthones in the resin of Garcinia hanburyi.
METHODS AND RESULTS:
The fragmentation of protonated molecular ions for 12 known cadged xanthones was carried out using low-energy collision-induced electrospray ionization tandem mass spectrometry. It was found that Retro-Diels-Alder rearrangement occurred in the CID processes and produced the characteristic fragment ions, which are especially valuable for the identification of this class of xanthones. The fragmentation differential between some cis-, trans-isomers was uncovered. Computation methods were utilized to rationalize the observed MS behaviors.
CONCLUSIONS:
On-line UHPLC-ESI-MS/MS/MS method has proved to be rapid and efficient in that within 6min, 15 caged scaffold xanthones, including three pairs of epimers and four pairs of isomers in gamboges, were effectively separated and identified. Among them, two known, namely isogambogenin (13) and Isomorellinol (14) and one likely new caged Garcinia xanthones from the Garcinia hanburyi were tentatively characterized based on the tandem mass spectra of known ones.

Product Name	Isomorellinol
Price:
CAS No.:	149655-53-8
Catalog No.:	CFN92095
Molecular Formula:	C₃₃H₃₈O₇
Molecular Weight:	546.7 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:	The herbs of Garcinia hanburyi Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Pro-apoptotic Compound Library Miscellaneous Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8292 mL	9.1458 mL	18.2916 mL	36.5831 mL	45.7289 mL
5 mM	0.3658 mL	1.8292 mL	3.6583 mL	7.3166 mL	9.1458 mL
10 mM	0.1829 mL	0.9146 mL	1.8292 mL	3.6583 mL	4.5729 mL
50 mM	0.0366 mL	0.1829 mL	0.3658 mL	0.7317 mL	0.9146 mL
100 mM	0.0183 mL	0.0915 mL	0.1829 mL	0.3658 mL	0.4573 mL

CFN92087	Deoxymorellin	1064-34-2	530.7	C₃₃H₃₈O₆
CFN92091	Gaudichaudic acid	887923-46-8	562.7	C₃₃H₃₈O₈
CFN92093	Morellic acid	5304-71-2	560.7	C₃₃H₃₆O₈
CFN92094	Isomorellic acid	5262-69-1	560.7	C₃₃H₃₆O₈
CFN95465	New compound 16	N/A	590.7	C₃₄H₃₈O₉
CFN92095	Isomorellinol	149655-53-8	546.7	C₃₃H₃₈O₇