Quasipanaxatriol | CAS:171903-78-9 | Manufacturer ChemFaces

Quasipanaxatriol

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Size /Price /Stock	10 mM * 1 mL in DMSO / $413 / In-stock
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Description:

Quasipanaxatriol can greatly enhance the cytotoxicity of the anti-cancer drugs in P388/ADM cells.

In vitro:

Planta Med 1995; 61(5): 409-413.

Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistant P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids.[Reference: WebLink]

METHODS AND RESULTS:
Examined in vitro were the effects of some triterpenoids from Panax (Araliaceae) and Glycyrrhiza (Leguminosae) spp. on the sensitivity to daunomycin (DAU) and vinblastine (VBL) of adriamycin (ADM)-resistant P388 leukemia cells (P388/ADM), which were resistant to multiple anticancer drugs. Quasipanaxatriol, 20(S)-protopanaxatriol, ginsenoside Rh2, and compound K greatly enhanced the cytotoxicity of the anti-cancer drugs in P388/ADM cells. The extent of enhancement was different among the triterpene compounds; the 4- to 46-fold increase in DAU cytotoxicity was observed in P388/ADM cells in the presence of non-toxic or marginally toxic concentrations of individual compounds, while those for VBL were in the ratios of 2- to 37-fold. The maximum increase in cytotoxicity was observed with 50 µM Quasipanaxatriol; the resistance indices defined to be the ratios of the IC50 values for P388/ADM and P388 parental cells decreased from 79 to 1.7 and from 180 to 4.9 in the cases of DAU and VBL, respectively.
CONCLUSIONS:
The reversal of DAU resistance in P388/ADM by Quasipanaxatriol could be explained by the effective accumulation of the drugs mediated by the DAU-efflux blockage.

Quasipanaxatriol Description

Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Quasipanaxatriol
Price:	$413 / 5mg
CAS No.:	171903-78-9
Catalog No.:	CFN95248
Molecular Formula:	C₃₀H₅₀O₃
Molecular Weight:	458.7 g/mol
Purity:	>95%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1801 mL	10.9004 mL	21.8007 mL	43.6015 mL	54.5019 mL
5 mM	0.436 mL	2.1801 mL	4.3601 mL	8.7203 mL	10.9004 mL
10 mM	0.218 mL	1.09 mL	2.1801 mL	4.3601 mL	5.4502 mL
50 mM	0.0436 mL	0.218 mL	0.436 mL	0.872 mL	1.09 mL
100 mM	0.0218 mL	0.109 mL	0.218 mL	0.436 mL	0.545 mL

CFN99965	Ginsenoside Rb2	11021-13-9	1079.27	C₅₃H₉₀O₂₂
CFN99966	Ginsenoside Rb3	68406-26-8	1079.27	C₅₃H₉₀O₂₂
CFN93283	Notoginsenoside Fc	88122-52-5	1211.4	C₅₈H₉₈O₂₆
CFN99964	Ginsenoside Rb1	41753-43-9	1109.29	C₅₄H₉₂O₂₃
CFN93284	Notoginsenoside Fa	88100-04-3	1241.4	C₅₉H₁₀₀O₂₇
CFN91142	Notoginsenoside R4	87741-77-3	1241.4	C₅₉H₁₀₀O₂₇
CFN93293	Ginsenoside Ra2	83459-42-1	1211.39	C₅₈H₉₈O₂₆
CFN93282	Notoginsenoside Fe	88105-29-7	917.12	C₄₇H₈₀O₁₇
CFN99973	Ginsenoside Rc	11021-14-0	1079.27	C₅₃H₉₀O₂₂
CFN99754	Ginsenoside F1	53963-43-2	638.88	C₃₆H₆₂O₉