Kihadanin B | CAS:73793-68-7 | Manufacturer ChemFaces

Kihadanin B

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Kihadanin B Description

Source:	The barks of Phellodendron amurense
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

J. Agric. Food Chem., 2016, 64 (51): 9607-15.

A limonoid kihadanin B from immature Citrus unshiu peels suppresses adipogenesis through repression of Akt-FOXO1-PPARγ axis in adipocytes[Reference: WebLink]

Citrus limonoids are secondary metabolites and exhibit a variety of biological activities.
METHODS AND RESULTS:
In this study, we elucidated the suppression of adipogenesis by a Citrus limonoid Kihadanin B and determined its molecular mechanism in mouse 3T3-L1 adipocytes. Kihadanin B was purified from the peels of immature Citrus unshiu by HPLC, and its chemical structure was determined by NMR and mass spectrometry. Kihadanin B reduced the lipid accumulation with the reduction of the expression levels of the adipogenic and lipogenic genes, but did not affect to lipolysis in adipocytes. Phosphorylation levels of Akt and a forkhead transcriptional factor, FOXO1, a repressor of PPARγ were lowered by Kihadanin B. Furthermore, Kihadanin B increased the binding level of FOXO1 to the PPARγ gene promoter in adipocytes.
CONCLUSIONS:
These results indicate that a Citrus limonoid Kihadanin B repressed the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.

Product Name	Kihadanin B
Price:
CAS No.:	73793-68-7
Catalog No.:	CFN92527
Molecular Formula:	C₂₆H₃₀O₉
Molecular Weight:	486.5 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The barks of Phellodendron amurense
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-adipogenic Compound Library Triterpenoids Compound Library PPAR Inhibitor Library Akt Inhibitor Library

Description:	Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
Targets:	Akt \| PPAR \| FOXO1

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0555 mL	10.2775 mL	20.555 mL	41.11 mL	51.3875 mL
5 mM	0.4111 mL	2.0555 mL	4.111 mL	8.222 mL	10.2775 mL
10 mM	0.2055 mL	1.0277 mL	2.0555 mL	4.111 mL	5.1387 mL
50 mM	0.0411 mL	0.2055 mL	0.4111 mL	0.8222 mL	1.0277 mL
100 mM	0.0206 mL	0.1028 mL	0.2055 mL	0.4111 mL	0.5139 mL

CFN92527	Kihadanin B	73793-68-7	486.5	C₂₆H₃₀O₉
CFN96926	21,23-Dihydro-23-hydroxy-21-oxozapoterin	426266-88-8	502.51	C₂₆H₃₀O₁₀
CFN95482	Kihadanin D	2770024-83-2	500.6	C₂₇H₃₂O₉
CFN97233	Obacunone	751-03-1	454.5	C₂₆H₃₀O₇
CFN98477	Zapoterin	35796-71-5	470.5	C₂₆H₃₀O₈
CFN99935	Nomilin	1063-77-0	514.56	C₂₈H₃₄O₉
CFN95646	Obacunonic acid	1961237-40-0	472.5	C₂₆H₃₂O₈
CFN95652	Methyl obacunoate	751-48-4	486.6	C₂₇H₃₄O₈
CFN95559	Nomilinic acid	35930-20-2	532.6	C₂₈H₃₆O₁₀
CFN95576	Methyl nomilinate	77887-51-5	546.6	C₂₉H₃₈O₁₀