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Koenigicine
Koenigicine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Koenigicine
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CAS No.: 24123-92-0
Catalog No.: CFN70319
Molecular Formula: C20H21NO3
Molecular Weight: 323.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Murraya koenigii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Harvard University (USA)
  • Macau University of Science and... (China)
  • Korea Food Research Institute(K... (Korea)
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Koenigicine has pancreatic lipase (PL) inhibitory activity in vitro.
In vitro:
Natural Product Communications, 2009, 4(8):1089-1092.
Pancreatic lipase inhibitory alkaloids of Murraya koenigii leaves.[Reference: WebLink]
In the continuing search for newer pancreatic lipase inhibitors from plants, a total of 63 extracts from 21 different plants were screened to study their pancreatic lipase (PL) inhibitory activity in vitro.
METHODS AND RESULTS:
All three extracts (DCM, EtOAc and MeOH) of Murraya koenigii (L.) Spreng leaves (Rutaceae) exhibited antilipase activity greater than 80%. Further, bioactivity guided fractionation of the EtOAc extract led to the isolation of four alkaloids, namely mahanimbin, koenimbin, Koenigicine and clausazoline-K, with IC50 values of 17.9 microM, 168.6 microM, 428.6 microM and <500 microM, respectively.
CONCLUSIONS:
This study reports for the first time the PL inhibitory potential of carbazole alkaloids from plants.
Koenigicine Description
Source: The herbs of Murraya koenigii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0921 mL 15.4607 mL 30.9215 mL 61.8429 mL 77.3036 mL
5 mM 0.6184 mL 3.0921 mL 6.1843 mL 12.3686 mL 15.4607 mL
10 mM 0.3092 mL 1.5461 mL 3.0921 mL 6.1843 mL 7.7304 mL
50 mM 0.0618 mL 0.3092 mL 0.6184 mL 1.2369 mL 1.5461 mL
100 mM 0.0309 mL 0.1546 mL 0.3092 mL 0.6184 mL 0.773 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN89173Glycoborinine233279-39-5279.33C18H17NO2
CFN96594Carbazole86-74-8167.21C12H9N
CFN977773-Methyl-9H-carbazol-2-ol24224-30-4197.23C13H11NO
CFN98862Glycozolinine5257-08-9197.2 C13H11NO
CFN97821Clausine D142846-95-5279.34C18H17NO2
CFN97840Demethylmurrayanine123497-84-7211.22C13H9NO2
CFN91484Murrayanine723-97-7225.2C14H11NO2
CFN91823Clausine E182261-83-2241.2C14H11NO3
CFN91427Clausine G186002-62-0271.3C15H13NO4
CFN97428Clausine Z866111-14-0227.2 C13H9NO3
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