Koenigicine | CAS:24123-92-0 | Manufacturer ChemFaces

Koenigicine

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Description:

Koenigicine has pancreatic lipase (PL) inhibitory activity in vitro.

In vitro:

Natural Product Communications, 2009, 4(8):1089-1092.

Pancreatic lipase inhibitory alkaloids of Murraya koenigii leaves.[Reference: WebLink]

In the continuing search for newer pancreatic lipase inhibitors from plants, a total of 63 extracts from 21 different plants were screened to study their pancreatic lipase (PL) inhibitory activity in vitro.
METHODS AND RESULTS:
All three extracts (DCM, EtOAc and MeOH) of Murraya koenigii (L.) Spreng leaves (Rutaceae) exhibited antilipase activity greater than 80%. Further, bioactivity guided fractionation of the EtOAc extract led to the isolation of four alkaloids, namely mahanimbin, koenimbin, Koenigicine and clausazoline-K, with IC50 values of 17.9 microM, 168.6 microM, 428.6 microM and <500 microM, respectively.
CONCLUSIONS:
This study reports for the first time the PL inhibitory potential of carbazole alkaloids from plants.

Koenigicine Description

Source:	The herbs of Murraya koenigii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Koenigicine
Price:
CAS No.:	24123-92-0
Catalog No.:	CFN70319
Molecular Formula:	C₂₀H₂₁NO₃
Molecular Weight:	323.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Murraya koenigii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0921 mL	15.4607 mL	30.9215 mL	61.8429 mL	77.3036 mL
5 mM	0.6184 mL	3.0921 mL	6.1843 mL	12.3686 mL	15.4607 mL
10 mM	0.3092 mL	1.5461 mL	3.0921 mL	6.1843 mL	7.7304 mL
50 mM	0.0618 mL	0.3092 mL	0.6184 mL	1.2369 mL	1.5461 mL
100 mM	0.0309 mL	0.1546 mL	0.3092 mL	0.6184 mL	0.773 mL

CFN97800	Clausine I	182261-94-5	241.24	C₁₄H₁₁NO₃
CFN97796	Clauszoline M	187110-72-1	227.22	C₁₃H₉NO₃
CFN92926	Curryangine	25488-37-3	331.45	C₂₃H₂₅NO
CFN92927	Murrayamine E	172617-68-4	347.45	C₂₃H₂₅NO₂
CFN91189	Koenimbine	21087-98-9	293.4	C₁₉H₁₉NO₂
CFN70319	Koenigicine	24123-92-0	323.4	C₂₀H₂₁NO₃
CFN92197	Mahanimbine	21104-28-9	331.5	C₂₃H₂₅NO
CFN92198	Isomahanimbine	26871-46-5	331.5	C₂₃H₂₅NO
CFN92199	Mahanine	28360-49-8	347.5	C₂₃H₂₅NO₂
CFN92200	Isomahanine	144606-95-1	347.5	C₂₃H₂₅NO₂