| Description: |
Licochalcone C has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activities; it shows inhibition of bacterial growth and cellular respiration. Licochalcone C exhibits inhibitory activity with cytotoxicity in a rat basophilic leukemia cell line, RBL-2H3. It induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells, it may be a potential adjuvant therapeutic agent for bladder cancer. |
| Targets: |
TNF-α | Caspase | Bcl-2/Bax |
| In vitro: |
| Arch Pharm Res. 2013 Dec;36(12):1432-6. | | Concise synthesis of licochalcone C and its regioisomer, licochalcone H.[Pubmed: 23897165] | Licochalone C (7a) is a retrochalcone isolated from Glycyrrhiza inflata, which shows potent antioxidant properties and inhibition of bacterial growth and cellular respiration.
METHODS AND RESULTS:
Biological studies have suggested that Licochalcone C attenuates the lipopolysaccharide and interferon-gamma induced inflammatory response by decreasing the expression and activity of inducible nitric oxide synthase and modulating the antioxidant network activity of superoxide dismutase, catalase, and glutathione peroxidase activity. Licochalcone C also inhibits NADH-cytochrome C reductase in the membrane fraction of Micrococcus luteus.
CONCLUSIONS:
Since pharmacological activity studies of Licochalcone C are ongoing and the yield of the compound is poor from natural product, we report a concise four step synthesis of Licochalcone C (7a) and its regioisomer, tentatively called licochalcone H (7b), by employing acid-mediated Claisen-Schmidt condensation as a key step with 6 and 20 % overall yield, respectively. |
|
| In vivo: |
| Life Sci. 2015 Apr 25. pii: S0024-3205(15)00228-3. | | Role of licochalcone C in cardioprotection against ischemia/reperfusion injury of isolated rat heart via antioxidant, anti-inflammatory, and anti-apoptotic activities.[Pubmed: 25921769] | This study aimed to evaluate the protective effect of Licochalcone C against myocardial ischemia/reperfusion injury in rats.
METHODS AND RESULTS:
Left ventricular developed pressure (LVDP) and its maximum up/down rate (±dp/dtmax) were recorded as myocardial function. Pretreatment with Licochalcone C significantly improved the recovery of LVDP and ±dp/dtmax, and increased the levels of SOD and GSH/GSSG ratio. However, pretreatment with Licochalcone C not only decreased the TUNEL-positive cell ratio and morphological changes, but also weaken the mitochondrial injury and the levels of CK, LDH, MDA, and TNF-α.
CONCLUSIONS:
These results suggested an important function of Licochalcone C extracted from traditional Chinese medicine in the cardioprotection via antioxidant, anti-inflammatory, and anti-apoptotic activities. |
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