Science | Nature | Cell | View More
Natural Products
Lindleyin
Lindleyin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Lindleyin
Price:
CAS No.: 59282-56-3
Catalog No.: CFN93045
Molecular Formula: C23H26O11
Molecular Weight: 478.45 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The herbs of Rheum palmatum L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universitas Airlangga (Indonesia)
  • Cancer Research Initatives Foun... (Malaysia)
  • Pennsylvania State University (USA)
  • University of Helsinki (Finland)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Shanghai Institute of Biochemis... (China)
  • Tokyo Woman's Christian University (Japan)
  • University of East Anglia (United Kingdom)
  • Johannes Gutenberg University M... (Germany)
  • Universidade Federal de Santa C... (Brazil)
  • Kitasato University (Japan)
  • More...
Package
Featured Products
Gastrodin

Catalog No: CFN99549
CAS No: 62499-27-8
Price: $30/20mg
Cauloside A

Catalog No: CFN96440
CAS No: 17184-21-3
Price: $318/10mg
Flavone

Catalog No: CFN70130
CAS No: 525-82-6
Price: $30/20mg
Hypericin

Catalog No: CFN99188
CAS No: 548-04-9
Price: $100/20mg
Forsythoside A

Catalog No: CFN99705
CAS No: 79916-77-1
Price: $50/20mg
Platycoside E

Catalog No: CFN90786
CAS No: 237068-41-6
Price: $ / mg
Curcumin

Catalog No: CFN98686
CAS No: 458-37-7
Price: $30/20mg
Asiatic acid

Catalog No: CFN98688
CAS No: 464-92-6
Price: $40/20mg
1-O-Acetylbritannilactone

Catalog No: CFN89438
CAS No: 33627-41-7
Price: $218/20mg
Neochamaejasmine B

Catalog No: CFN92152
CAS No: 90411-12-4
Price: $318/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
Targets: Estrogen receptor | Progestogen receptor
In vitro:
J Endocrinol. 2002 Nov;175(2):289-96.
The phytochemical lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors.[Pubmed: 12429027]
Some plant compounds or herb mixtures are popular alternatives to conventional therapies and contain organic compounds that bind to some nuclear receptors, such as the estrogen receptor (ER), to exert various biological effects. We studied the effect of various herbal extracts on ERalpha and ERbeta isoforms.
METHODS AND RESULTS:
One herbal extract, Rhei rhizoma (rhubarb), acts as an agonist to both ERalpha and ERbeta. The phytochemical Lindleyin, a major component of rhubarb, might contribute to this estrogenic activity through ERalpha and ERbeta. 4-Hydroxytamoxifen, an ER antagonist, completely reversed the estrogenic activity of Lindleyin. Lindleyin binds to ERalpha in vitro, as demonstrated using a fluorescent polarization assay. The in vivo effect of rhubarb extract was studied using a vitellogenin assay system in the freshwater fish, Japanese medaka (Oryzias latipes). There were marked increases in serum vitellogenin levels in male medaka exposed to rhubarb extract.
CONCLUSIONS:
We conclude that Lindleyin, a component of some herbal medicines, is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
Chem Pharm Bull (Tokyo). 2000 Jul;48(7):1055-61.
Prolyl endopeptidase inhibitory activity of fourteen Kampo formulas and inhibitory constituents of Tokaku-joki-to.[Pubmed: 10923840]
Prolyl endopeptidase (PEP, EC 3.4.21.26) is an enzyme playing a role in the metabolism of proline-containing neuropeptides which have been suggested to be involved in learning and memory processes.
METHODS AND RESULTS:
In screening for PEP inhibitors from fourteen traditional Kampo formulas, we found that Tokaku-joki-to shows a significant inhibitory activity. Examination of the constituents of the Kampo formula resulted in the isolation of two new compounds, cis-3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside (10) and 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(6-O-galloyl-2-O-cinnamoyl)glucopyranoside (16), along with twenty-five known compounds, cinnamic acid (1), protocatechuic acid (2), gallic acid (3), torachrysone 8-O-beta-D-glucoside (4), emodin (5), emodin 8-O-beta-D-glucoside (6), 3,5,4'-trihydroxystilbene 4'-O-beta-D-glucopyranoside (7), 3,5,4'-trihydroxystilbene 4'-O-beta-D-(2-O-galloyl)glucopyranoside (8), 3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside (9), 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-glucopyranoside (11), isoLindleyin (12), Lindleyin (13), 4(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2,6-di-O-galloyl)glucopyranoside (14), 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside (15), 1-O-galloylglucose (17), 1,2,6-tri-O-galloylglucose (18), gallic acid 4-O-beta-D-(6-O-galloyl)glucopyranoside (19), liquiritigenin (20), liquiritigenin 4'-O-beta-D-glucoside (21), liquiritigenin 7,4'-diglucoside (22), liquiritigenin 4'-O-beta-D-apiofuranosyl-(1-->2)-beta-D-glucopyranoside (23), licuroside (24), (-)-epicatechin (25), (-)-epicatechin 3-O-gallate (26) and (+)-catechin (27).
CONCLUSIONS:
Among these compounds, twelve (7-10, 14-16, 18, 19, 24-26) showed noncompetitive inhibition with an IC50 of 22.9, 3.0, 14.9, 2.8, 10.5, 0.69, 8.2, 0.44, 9.39, 26.5, 28.1 and 0.052 microM, respectively.
Lindleyin Description
Source: The herbs of Rheum palmatum L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Isorhamnetin-3-O-rutinoside-7-O-gl...

Catalog No: CFN95494
CAS No: 55481-91-9
Price: $318/5mg
Ganoderiol D

Catalog No: CFN95568
CAS No: 114567-45-2
Price: $413/5mg
(Z)-Ferulic acid 4-O-beta-D-glucos...

Catalog No: CFN95546
CAS No: 94942-20-8
Price: $318/10mg
Fragransin B1

Catalog No: CFN95443
CAS No: 112516-03-7
Price: $318/5mg
Dactylorhin A

Catalog No: CFN95032
CAS No: 256459-34-4
Price: $238/20mg
Notoginsenoside L13

Catalog No: CFN95332
CAS No: 2485859-56-9
Price: $318/5mg
2-(2,4-Dihydroxyphenyl)-5,6-methyl...

Catalog No: CFN95511
CAS No: 67121-26-0
Price: $318/5mg
Eschweilenol C

Catalog No: CFN95363
CAS No: 211371-02-7
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0901 mL 10.4504 mL 20.9008 mL 41.8017 mL 52.2521 mL
5 mM 0.418 mL 2.0901 mL 4.1802 mL 8.3603 mL 10.4504 mL
10 mM 0.209 mL 1.045 mL 2.0901 mL 4.1802 mL 5.2252 mL
50 mM 0.0418 mL 0.209 mL 0.418 mL 0.836 mL 1.045 mL
100 mM 0.0209 mL 0.1045 mL 0.209 mL 0.418 mL 0.5225 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Gastrodin

Catalog No: CFN99549
CAS No: 62499-27-8
Price: $30/20mg
Cauloside A

Catalog No: CFN96440
CAS No: 17184-21-3
Price: $318/10mg
Flavone

Catalog No: CFN70130
CAS No: 525-82-6
Price: $30/20mg
Hypericin

Catalog No: CFN99188
CAS No: 548-04-9
Price: $100/20mg
Forsythoside A

Catalog No: CFN99705
CAS No: 79916-77-1
Price: $50/20mg
Platycoside E

Catalog No: CFN90786
CAS No: 237068-41-6
Price: $ / mg
Curcumin

Catalog No: CFN98686
CAS No: 458-37-7
Price: $30/20mg
Asiatic acid

Catalog No: CFN98688
CAS No: 464-92-6
Price: $40/20mg
1-O-Acetylbritannilactone

Catalog No: CFN89438
CAS No: 33627-41-7
Price: $218/20mg
Neochamaejasmine B

Catalog No: CFN92152
CAS No: 90411-12-4
Price: $318/5mg
Tags: buy Lindleyin | Lindleyin supplier | purchase Lindleyin | Lindleyin cost | Lindleyin manufacturer | order Lindleyin | Lindleyin distributor