| In vitro: |
| Natural Product Research, 2017:1-5. | | Liriopesides B inhibited cell growth and decreased CA125 level in human ovarian cancer A2780 cells.[Reference: WebLink] | To study the effect of Liriopesides B on cell growth curve, cell doubling time, the activity of tumour marker CA125 and alkaline phosphatase (AKP) in human ovarian cancer A2780 cells.
METHODS AND RESULTS:
Both cell growth curve and doubling time were studied by MTT assay, CA125 level and AKP activity were determined by respective kits. Results showed that Liriopesides B could shift down the A2780 cells growth curve in a dose-time-dependent manner and inhibit the proliferation in A2780 cells with the maximum inhibitory rate 94.462% at 120 h, the doubling time was prolonged too. CA125 level was decreased in a dose-dependent way as well as AKP activity.
CONCLUSIONS:
Liriopesides B exhibited potential anticancer activity against human ovarian cancer A2780 cells. | | Food Research and Development, 2018. | | Study on Activities of Polysaccharide and Liriopesides B from Liriope Spicata Lour. var. Prolifera Y. T. Ma in Vitro.[Reference: WebLink] | Polysaccharide fromLiriope Spicata Lour. var. Prolifera Y. T. Ma was extracted via hot water extraction and alcohol precipitation method,and its antioxidant activities in vitro were studied.
METHODS AND RESULTS:
Bacteriostatic experiments of different concentrations Liriopesides B was performed by the method of filter paper. Results showed that polysaccharide exhibited different antioxidant activity,with maximum scavenging ability on superoxide anion free radical,up to 70.83 %,medium scavenging capacity on hydroxyl radical(25.69 %),and minimum on DPPH free radical. Different concentrations Liriopesides B(2.0 and 4.0 mg/mL)showed obvious inhibitory effect on both bacteria,bacteriostatic ring diameter of Escherichia coli were(10.83±0.82)mm and(14.89 ±0.50)mm respectively,and the diameter of Staphylococcus aureus were(11.63 ±0.33)mm and(17.05 ±0.67) mm respectively. At the same concentration,Staphylococcus aureus was more sensitive to Liriopesides B than Escherichia coli.
CONCLUSIONS:
In short,polysaccharide and Liriopesides B fromLiriope Spicata Lour. var.Prolifera Y. T. Ma showed obvious antioxidant and bacteriostatic activities. |
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Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)