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Luteolinidin chloride
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Product Name Luteolinidin chloride
Price:
CAS No.: 1154-78-5
Catalog No.: CFN91858
Molecular Formula: C15H11ClO5
Molecular Weight: 306.7 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The fruits of Vaccinium myrtillus
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Luteolinidin chloride (100µM) can significantly blunt the effects of NAD on the cellular responses to GD.
In vitro:
Journal of Food Biochemistry, 2010, 32(5):576-596.
Anthocyanin Interactions with DNA: Intercalation, Topoisomerase I Inhibition and Oxidative Reactions.[Pubmed: 19924259]
Anthocyanins and their aglycone anthocyanidins are pigmented flavonoids found in significant amounts in many commonly consumed foods. They exhibit a complex chemistry in aqueous solution, which makes it difficult to study their chemistry under physiological conditions.
METHODS AND RESULTS:
Here we used a gel electrophoresis assay employing supercoiled DNA plasmid to examine the ability of these compounds (1) to intercalate DNA, (2) to inhibit human topoisomerase I through both inhibition of plasmid relaxation activity (catalytic inhibition) and stabilization of the cleavable DNA-topoisomerase complex (poisoning), and (3) to inhibit or enhance oxidative single-strand DNA nicking. We found no evidence of DNA intercalation by anthocyan(id)ins in the physiological pH range for any of the compounds used in this study-cyanidin chloride, cyanidin 3-O-glucoside, cyanidin 3,5-O-diglucoside, malvidin 3-O-glucoside and Luteolinidin chloride. The anthocyanins inhibited topoisomerase relaxation activity only at high concentrations (> 50 muM) and we could find no evidence of topoisomerase I cleavable complex stabilization by these compounds. However, we observed that all of the anthocyan(id)ins used in this study were capable of inducing significant oxidative DNA strand cleavage (nicking) in the presence of 1 mM DTT (dithiothreitol), while the free radical scavenger, DMSO, at concentrations typically used in similar studies, completely inhibited DNA nicking.
CONCLUSIONS:
Finally, we propose a mechanism to explain the anthocyan(id)in induced oxidative DNA cleavage observed under our experimental conditions.
Luteolinidin chloride Description
Source: The fruits of Vaccinium myrtillus
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2605 mL 16.3026 mL 32.6052 mL 65.2103 mL 81.5129 mL
5 mM 0.6521 mL 3.2605 mL 6.521 mL 13.0421 mL 16.3026 mL
10 mM 0.3261 mL 1.6303 mL 3.2605 mL 6.521 mL 8.1513 mL
50 mM 0.0652 mL 0.3261 mL 0.6521 mL 1.3042 mL 1.6303 mL
100 mM 0.0326 mL 0.163 mL 0.3261 mL 0.6521 mL 0.8151 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Synthesis, 2003(12):1878-1880.
A New and Convenient One-StepSynthesis of the Natural 3-Deoxyantho­cyanidins Apigeninidinand Luteolinidin Chlorides from 2,4,6-Triacetoxy­benzaldehyde.[Reference: WebLink]

METHODS AND RESULTS:
The total synthesis of apigeninidin chloride (1), Luteolinidin chloride(2) and 5,7-dihydroxyflavylium chloride(5) is performed through a one step reaction from an acetylated derivative of a commercial reagent. Condensation reaction between 2,4,6-triacetoxybenzaldehyde and an acetophenone derivative in anhyd methanolic hydrogen chloride provides the 3-deoxyanthocyanidins in high yields.
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