Macrocarpal B | CAS:142698-60-0 | Manufacturer ChemFaces

Macrocarpal B

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Description:

The intestinal absorption of M-A, Macrocarpal B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent.

Targets:

c-Met

In vitro:

Bioorg Med Chem Lett. 2007 Feb 15;17(4):1107-11.

Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.[Pubmed: 17118653]

The uptake and transepithelial transport of the three main constituents macrocarpal A (M-A), Macrocarpal B (M-B), and cypellocarpa C (Cy-C) from the fruits of Eucalyptus globulus Labill. were investigated.
METHODS AND RESULTS:
Monolayers of the human intestinal epithelial cancer cell line Caco-2 were incubated with M-A, Macrocarpal B, and Cy-C to model its intestinal absorption and transport, respectively. The determination of compounds was performed by HPLC. The apparent permeability coefficients (P(app)) for M-A, Macrocarpal B, and Cy-C in the apical-to-basolateral direction of a Caco-2 monolayer were (1.70+/-0.06)x10(-6), (1.99+/-0.10)x10(-6), and (6.08+/-0.41)x10(-6)cm/s, respectively. In the presence of iodoacetamide, the P(app) of Cy-C were both reducted in apical-to-basolateral and basolateral-to-apical directions. M-A and Macrocarpal B appear to accumulate in the epithelial cells.
CONCLUSIONS:
The intestinal absorption of M-A, Macrocarpal B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent.

Macrocarpal B Description

Source:	The branches of Eucalyptus globulus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Zhongguo Zhong Yao Za Zhi. 2007 Mar;32(6):496-500.

[Studies on chemical constituents in fruits of Eucalyptus globulus].[Pubmed: 17552153]

To study the chemical constituents in the fruits of Eucalyptus globulus Labill.
METHODS AND RESULTS:
The chemical constituents were isolated by various column chromatographic methods and structurally elucidated by IR, NMR and MS evidences. Fifteen compounds were obtained and identified as beta-sitosterol (1), betulinic acid (2), stigmasterol (3), euscaphic acid (4), 2a-Hydroxybetulinic acid (5), Macrocarpal B (6), macrocarpal A (7), oleanolic acid (8), 3,4,3'-O-trimethylellagic acid (9), 3-O-methylellagic acid 4'-O-(2"-O-acetyl )-alpha-L-rhamnopyranoside (10), camaldulenside (cypellocarpin C, 11), 3-O-methylellagic acid 4'-O-alpha-L-rhamnopyranoside (12), 3-O-methylellagic acid (13), ellagic acid (14), and gallic acid (15).
CONCLUSIONS:
Compounds 4 and 5 from genera Eucalyptus, 1, 3 and 11 from plant E. globulus, and 6, 7, 9 and 15 from the fruits of E. globulus were isolated for the first time.

Biosci. Biotech. Biochem., 1995, 59(12):2330-2.

New Macrocarpal-am-1 from Eucalyptus amplifolia.[Reference: WebLink]

METHODS AND RESULTS:
Four macrocarpals (macrocarpal A, Macrocarpal B, Macrocarpal E, and macrocarpal am-1) were isolated from the leaves of Eucalyptus amplifolia.
CONCLUSIONS:
Macrocarpal-am-1 is a new macrocarpal in which the isopentyl phloroglucinol chromophore is coupled with the 1,10-secoaromadendrane skeleton. Its structure is elucidated by spectral techniques.

Product Name	Macrocarpal B
Price:
CAS No.:	142698-60-0
Catalog No.:	CFN99472
Molecular Formula:	C₂₈H₄₀O₆
Molecular Weight:	472.6 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Yellow powder
Source:	The branches of Eucalyptus globulus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Sesquiterpenoids Compound Library c-Met Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.116 mL	10.5798 mL	21.1595 mL	42.3191 mL	52.8989 mL
5 mM	0.4232 mL	2.116 mL	4.2319 mL	8.4638 mL	10.5798 mL
10 mM	0.2116 mL	1.058 mL	2.116 mL	4.2319 mL	5.2899 mL
50 mM	0.0423 mL	0.2116 mL	0.4232 mL	0.8464 mL	1.058 mL
100 mM	0.0212 mL	0.1058 mL	0.2116 mL	0.4232 mL	0.529 mL

CFN99469	Macrocarpal C	142628-53-3	454.6	C₂₈H₃₈O₅
CFN99413	Macrocarpal A	132951-90-7	472.6	C₂₈H₄₀O₆
CFN99472	Macrocarpal B	142698-60-0	472.6	C₂₈H₄₀O₆
CFN99471	Macrocarpal D	142647-71-0	472.6	C₂₈H₄₀O₆
CFN99813	Eucalyptone	172617-99-1	486.6	C₂₈H₃₈O₇
CFN99008	Macrocarpal N	221899-21-4	486.6	C₂₈H₃₈O₇