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Neopetasitenine
Neopetasitenine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Neopetasitenine
Price:
CAS No.: 60409-51-0
Catalog No.: CFN00402
Molecular Formula: C21H29NO8
Molecular Weight: 423.46 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Petasites japonicus Maxim.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Petasitenine and neopetasitenine show strong hepatotoxic activity.
In vitro:
Biochemical Systematics and Ecology,2007,35(10): 676–681.
Pyrrolizidine alkaloids in the antipodean genus Brachyglottis (Asteraceae)[Reference: WebLink]

METHODS AND RESULTS:
Perdicioides “Alfred Atkinson” horticultural hybrid; Brachyglottis sciadophila contained clivorine and Neopetasitenine (acetylfukinotoxin); the latter alkaloid was also present in B. kirkii together with the previously reported senkirkine and senkirkine 12-acetate.
Neopetasitenine Description
Source: The herbs of Petasites japonicus Maxim.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3615 mL 11.8075 mL 23.615 mL 47.23 mL 59.0375 mL
5 mM 0.4723 mL 2.3615 mL 4.723 mL 9.446 mL 11.8075 mL
10 mM 0.2361 mL 1.1807 mL 2.3615 mL 4.723 mL 5.9037 mL
50 mM 0.0472 mL 0.2361 mL 0.4723 mL 0.9446 mL 1.1807 mL
100 mM 0.0236 mL 0.1181 mL 0.2361 mL 0.4723 mL 0.5904 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chemistry Letters, 1976 (5) :461-464.
Isolation and the structures of two new alkaloids, petasitenine and neopetasitenine, from Petasites japonicus Maxim[Reference: WebLink]

METHODS AND RESULTS:
Two new pyrrolizidine alkaloids revealing strong hepatotoxic activity were isolated from Petasites japonicus Maxim., and their structures were deduced to be petasitenine (3) and Neopetasitenine (4), respectively based on chemical and spectral evidence.
CFN00391Floridanine16958-31-9441.48C21H31NO9
CFN00393Desacetyldoronine120481-77-8417.89C19H28ClNO7
CFN00394Doronine60367-00-2459.92C21H30ClNO8
CFN00395Otosenine16958-29-5381.42C19H27NO7
CFN00396Florosenine16958-30-8423.46C21H29NO8
CFN00401Petasitenine60102-37-6381.42C19H27NO7
CFN00402Neopetasitenine60409-51-0423.46C21H29NO8
CFN00425Neoligularidine90364-91-3407.46C21H29NO7
CFN00426Neosenkirkine57194-70-4365.42C19H27NO6
CFN00428Acetylanonamine138079-62-6423.46C21H29NO8
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