Notoginsenoside Fc | CAS:88122-52-5 | Manufacturer ChemFaces

Notoginsenoside Fc

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Size /Price /Stock	10 mM * 1 mL in DMSO / $89.1 / In-stock
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Description:

Notoginsenoside Fc has perfect anti-platelet aggregatory effect.

Targets:

PAFR

In vivo:

J Pharm Biomed Anal. 2015 May 10;109:150-7.

Pharmacokinetics, bioavailability, and metabolism of Notoginsenoside Fc in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.[Pubmed: 25770412]

Notoginsenoside Fc (NGFc) is a protopanaxadiol-type (PPD-type) saponin from Panax notoginseng, which has perfect anti-platelet aggregatory effect. However, its pharmacokinetics and metabolism in vivo remain unknown.
METHODS AND RESULTS:
In this study, a simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC-MS/MS) method was first developed for the determination of NGFc in rat plasma. After methanol-mediated protein precipitation, separation was achieved on a C18 column with MS detection operated in negative SRM mode at m/z 604.56→m/z 783.90 and m/z 799.93→m/z 637.64 for NGFc and IS, respectively. The assay was linear over the concentration range (r>0.995) with the LLOQ of 0.002μg/ml. The intra- and inter-day precisions (R.S.D.) were 2.45-12.36% and 3.67-14.22%, respectively; whereas accuracy ranged from (R.R.) 93.90% to 99.41%. The extraction recovery, stability, and matrix effect were within the acceptable limits.
CONCLUSIONS:
The validated LC-MS/MS method was successfully applied to the pre-clinical pharmacokinetic studies of NGFc in rat. After oral and intravenous administration, NGFc showed dose-independent pharmacokinetic behaviors with a t1/2 of >22h and its oral bioavailability was 0.10-0.14%. In addition, a total of 10 metabolites were detected and structurally characterized by UPLC-Q/TOF-MS technique, which suggested that deglycosylation was the major metabolic pathway for NGFc in rats.

Notoginsenoside Fc Description

Source:	The roots of Panax notoginseng
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Notoginsenoside Fc
Price:	$198 / 20mg
CAS No.:	88122-52-5
Catalog No.:	CFN93283
Molecular Formula:	C₅₈H₉₈O₂₆
Molecular Weight:	1211.4 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Panax notoginseng
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-platelet aggregation Compound Library Triterpenoids Compound Library PAFR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.8255 mL	4.1275 mL	8.2549 mL	16.5098 mL	20.6373 mL
5 mM	0.1651 mL	0.8255 mL	1.651 mL	3.302 mL	4.1275 mL
10 mM	0.0825 mL	0.4127 mL	0.8255 mL	1.651 mL	2.0637 mL
50 mM	0.0165 mL	0.0825 mL	0.1651 mL	0.3302 mL	0.4127 mL
100 mM	0.0083 mL	0.0413 mL	0.0825 mL	0.1651 mL	0.2064 mL

CFN95034	Ginsenoside F5	189513-26-6	771.0	C₄₁H₇₀O₁₃
CFN99967	Ginsenoside Rg1	22427-39-0	801.01	C₄₂H₇₂O₁₄
CFN99999	Notoginsenoside R1	80418-24-2	933.13	C₄₇H₈₀O₁₈
CFN99974	Ginsenoside Re	52286-59-6	947.15	C₄₈H₈₂O₁₈
CFN99975	Ginsenoside Rd	52705-93-8	947.2	C₄₈H₈₂O₁₈
CFN93372	Gypenoside XLVI	94705-70-1	963.2	C₄₈H₈₂O₁₉
CFN90757	Ginsenoside F4	181225-33-2	767.0	C₄₂H₇₀O₁₂
CFN95248	Quasipanaxatriol	171903-78-9	458.7	C₃₀H₅₀O₃
CFN95232	Ginsenoside MC	175484-06-7	755.0	C₄₁H₇₀O₁₂
CFN96182	Gynosaponin I	1207861-69-5	769.0	C₄₂H₇₂O₁₂