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Notoginsenoside Fc
Notoginsenoside Fc
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Notoginsenoside Fc
Price: $198 / 20mg
CAS No.: 88122-52-5
Catalog No.: CFN93283
Molecular Formula: C58H98O26
Molecular Weight: 1211.4 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The roots of Panax notoginseng
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $89.1 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Notoginsenoside Fc has perfect anti-platelet aggregatory effect.
Targets: PAFR
In vivo:
J Pharm Biomed Anal. 2015 May 10;109:150-7.
Pharmacokinetics, bioavailability, and metabolism of Notoginsenoside Fc in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.[Pubmed: 25770412]
Notoginsenoside Fc (NGFc) is a protopanaxadiol-type (PPD-type) saponin from Panax notoginseng, which has perfect anti-platelet aggregatory effect. However, its pharmacokinetics and metabolism in vivo remain unknown.
METHODS AND RESULTS:
In this study, a simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC-MS/MS) method was first developed for the determination of NGFc in rat plasma. After methanol-mediated protein precipitation, separation was achieved on a C18 column with MS detection operated in negative SRM mode at m/z 604.56→m/z 783.90 and m/z 799.93→m/z 637.64 for NGFc and IS, respectively. The assay was linear over the concentration range (r>0.995) with the LLOQ of 0.002μg/ml. The intra- and inter-day precisions (R.S.D.) were 2.45-12.36% and 3.67-14.22%, respectively; whereas accuracy ranged from (R.R.) 93.90% to 99.41%. The extraction recovery, stability, and matrix effect were within the acceptable limits.
CONCLUSIONS:
The validated LC-MS/MS method was successfully applied to the pre-clinical pharmacokinetic studies of NGFc in rat. After oral and intravenous administration, NGFc showed dose-independent pharmacokinetic behaviors with a t1/2 of >22h and its oral bioavailability was 0.10-0.14%. In addition, a total of 10 metabolites were detected and structurally characterized by UPLC-Q/TOF-MS technique, which suggested that deglycosylation was the major metabolic pathway for NGFc in rats.
Notoginsenoside Fc Description
Source: The roots of Panax notoginseng
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.8255 mL 4.1275 mL 8.2549 mL 16.5098 mL 20.6373 mL
5 mM 0.1651 mL 0.8255 mL 1.651 mL 3.302 mL 4.1275 mL
10 mM 0.0825 mL 0.4127 mL 0.8255 mL 1.651 mL 2.0637 mL
50 mM 0.0165 mL 0.0825 mL 0.1651 mL 0.3302 mL 0.4127 mL
100 mM 0.0083 mL 0.0413 mL 0.0825 mL 0.1651 mL 0.2064 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 1992 Oct;17(10):611-3, 639-40 concl.
Saponins in the fruit pedicels of Panax notoginseng (Burk.) F.H. Chen (continue).[Pubmed: 1294178]
Six saponins were isolated from the fruit pedicels of Panax notoginseng.
METHODS AND RESULTS:
Five of them were identified as gypenoside-XVII, -XV, ginsenoside-Rb1, and notoginsenoside-Fc, -Fa on the basis of chemical methods, spectroscopic analysis and comparison with authentic standards.
CONCLUSIONS:
Quantitative determination of the major saponins in fruit pedicels from the plant was made by thin layer chromatography-densitometry.
CFN99999Notoginsenoside R180418-24-2933.13C47H80O18
CFN99974Ginsenoside Re52286-59-6947.15C48H82O18
CFN99975Ginsenoside Rd52705-93-8947.2C48H82O18
CFN95836Notoginsenoside E193976-50-0979.2C48H82O20
CFN93372Gypenoside XLVI94705-70-1963.2C48H82O19
CFN90757Ginsenoside F4181225-33-2767.0C42H70O12
CFN95248Quasipanaxatriol171903-78-9458.7C30H50O3
CFN95232Ginsenoside MC175484-06-7755.0C41H70O12
CFN96182Gynosaponin I1207861-69-5769.0C42H72O12
CFN95331Gynosaponin TN277658-95-8785.0C42H72O13
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