Oleoside | CAS:178600-68-5 | Manufacturer ChemFaces

Oleoside

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Description:

Oleacein is a strong Angiotensin Converting Enzyme (ACE)-inhibitor (IC50 = 26 uM).

In vitro:

Phytomedicine, 1996, 2(4):319-25.

Isolation of an angiotensin converting enzyme (ACE) inhibitor from Olea europaea and Olea lancea.[Pubmed: 23194770 ]

METHODS AND RESULTS:
The aqueous extract of the leaves of Olea europaea and Olea lancea both inhibited Angiotensin Converting Enzyme (ACE) in vitro. A bioassay-directed fractionation resulted in the isolation of a strong ACE-inhibitor namely the secoiridoid 2-(3,4-dihydroxyphenyl)ethyl 4-formyl-3-(2-oxoethyl)-4 E-hexenoate (oleacein) (IC(50) = 26 μM). Five secoiridoid glycosides (oleuropein, ligstroside, excelcioside, Oleoside 11-methyl ester, Oleoside) isolated from Oleaceous plants showed no significant ACE-inhibition whereas, after enzymatic hydrolysis, the ACE-inhibition at 0.33 mg/ml was between 64% to 95%. Secoiridoids have not been described previously in the literature as inhibitors of ACE.
CONCLUSIONS:
Oleacein showed a low toxicity in the brine shrimp (Artemia satina) lethality test (LC(50) (24 h) = 969 ppm).

Oleoside Description

Source:	The herbs of Lepidium sativum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Oleoside
Price:
CAS No.:	178600-68-5
Catalog No.:	CFN99838
Molecular Formula:	C₁₆H₂₂O₁₁
Molecular Weight:	390.3 g/mol
Purity:	>=98%
Type of Compound:	Iridoids
Physical Desc.:	Powder
Source:	The herbs of Lepidium sativum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Iridoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5621 mL	12.8107 mL	25.6213 mL	51.2426 mL	64.0533 mL
5 mM	0.5124 mL	2.5621 mL	5.1243 mL	10.2485 mL	12.8107 mL
10 mM	0.2562 mL	1.2811 mL	2.5621 mL	5.1243 mL	6.4053 mL
50 mM	0.0512 mL	0.2562 mL	0.5124 mL	1.0249 mL	1.2811 mL
100 mM	0.0256 mL	0.1281 mL	0.2562 mL	0.5124 mL	0.6405 mL

CFN98159	Cornuside	131189-57-6	542.49	C₂₄H₃₀O₁₄
CFN90972	Depressine	176182-06-2	688.63	C₃₀H₄₀O₁₈
CFN95365	7-O-(4-beta-D-glucopyranosyloxy-3-methoxybenzoyl)secologanolic acid	469899-55-6	688.6	C₃₀H₄₀O₁₈
CFN95374	New compound 13	N/A	718.7	C₃₁H₄₂O₁₉
CFN97045	Grandifloroside	61186-24-1	538.5	C₂₅H₃₀O₁₃
CFN95685	Grandifloroside-3''-glucoside	N/A	700.7	C₃₁H₄₀O₁₈
CFN95686	Periclymenosidic acid	96681-56-0	714.7	C₃₂H₄₂O₁₈
CFN98484	Ligustroside	35897-92-8	524.5	C₂₅H₃₂O₁₂
CFN91625	Oleuropein aglycone	31773-95-2	378.4	C₁₉H₂₂O₈
CFN98416	Oleuropein	32619-42-4	540.5	C₂₅H₃₂O₁₃