Oroxin A | CAS:57396-78-8 | Manufacturer ChemFaces

Oroxin A

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $25.4 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Oroxin A is a xanthine oxidase (XO) inhibitor, it exerts its antibreast cancer effects by inducing ER stress-mediated senescence, activating the key stress signaling pathway, and increasing key ER stress genes and expression levels.

Targets:

In vitro:

Anticancer Drugs. 2016 Mar;27(3):204-15.

Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence.[Pubmed: 26599214 ]

Breast cancer is a major cause of cancer death among women. Although various anticancer drugs have been used in clinics, drugs that are effective against advanced and metastatic breast cancer are still lacking and in great demand.
METHODS AND RESULTS:
In this study, we found that Oroxin A, an active component isolated from the herb Oroxylum indicum (L.) Kurz, effectively inhibited the growth of human breast cancer cells MDA-MB-231 and MCF7 by inducing endoplasmic reticulum (ER) stress-mediated senescence. Oroxin A caused breast cancer cell cycle arrest at the G2/M stage, and reorganization of microtubules and actin cytoskeleton accompanied by a decrease in cellular mitosis. ER-specific probe ER-Tracker Red and confocal microscope imaging showed that ER-Tracker Red-positive cells increased in an Oroxin A dosage-dependent manner. In addition, Oroxin A increased cell population with high β-Gal activity and SAHF-positive staining; these data suggest that Oroxin A induces breast cancer cell ER stress and senescence. Mechanistic studies showed that Oroxin A led to a significant increase in intracellular reactive oxygen species levels, promoted expression of ER stress markers ATF4 and GRP78, and increased the phosphorylation of a key stress-response signaling protein p38, resulting in an ER stress-mediated senescence.
CONCLUSIONS:
Taken together, our data indicate that Oroxin A exerts its antibreast cancer effects by inducing ER stress-mediated senescence, activating the key stress p38 signaling pathway, and increasing key ER stress genes ATF4 and GRP78 expression levels.

Oroxin A Description

Source:	The roots of Scutellaria baicalensis.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Yao Xue Xue Bao. 2006 Apr;41(4):380-4.

[Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS].[Pubmed: 16856488]

To establish a comprehensive HPLC analytical method of Huanglianjiedu decoction.
METHODS AND RESULTS:
This study was performed by HPLC-UV/MS to identify the chemical constituents of the whole and individual herbs of the "Huanglianjiedu decoction". Zorbax Extend C18 (150 mm x 4. 6 mm ID, 5 microm) column was used; the mobile phase was composed of acetonitrile (A) and water (B, with 0.5% acetic acid) with gradient elution; the flow rate was 1.0 mL x min(-1) and the column temperature was setup at 25 degrees C. The detection wavelength was 254 nm. The chromatogram of Huanglianjiedu decoction showed 21 main peaks. Peaks 1, 2, 5 and 18 were from Gardenia jasminoides Ellis, Peaks 8, 13, 14, 15, 16, 17, 19 and 21 from Scutellaria baicalensis Georgi. While 10 from Coptis chinensis Franch and 20 from Phellodendron amurense Rupr., Peaks 3, 4, 6, 9, 11 and 12 came from them together. Peak 7 presented in the chromatograms of the herbs except Gardenia jasminoides Ellis. By comparison of the retention time, the on-line UV spectra and MS spectra, 11 peaks were identified as 5 (geniposide), 9 (jatrorrhizine), 10 (coptisine), 11 (palmatine), 12 (berberine), 13 (baicalin), 15 (Oroxin A), 17 (wogonoside), 19 (baicalein), 20 (obaculactone), 21 (wogonin), then eight of them were quantified by HPLC-UV.
CONCLUSIONS:
The method could represent the characteristics of Huanglianjiedu decoction, and it could be used to evaluate the quality and quantity of Huanglianjiedu decoction. It distinguished between Coptis chinensis Franch and Phellodendron amurense Rupr. by HPLC for the first time.

Product Name	Oroxin A
Price:	$128 / 20mg
CAS No.:	57396-78-8
Catalog No.:	CFN99712
Molecular Formula:	C₂₁H₂₀O₁₀
Molecular Weight:	432.38 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The roots of Scutellaria baicalensis.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3128 mL	11.5639 mL	23.1278 mL	46.2556 mL	57.8195 mL
5 mM	0.4626 mL	2.3128 mL	4.6256 mL	9.2511 mL	11.5639 mL
10 mM	0.2313 mL	1.1564 mL	2.3128 mL	4.6256 mL	5.782 mL
50 mM	0.0463 mL	0.2313 mL	0.4626 mL	0.9251 mL	1.1564 mL
100 mM	0.0231 mL	0.1156 mL	0.2313 mL	0.4626 mL	0.5782 mL

CFN97852	Andrographidine C	113963-39-6	460.44	C₂₃H₂₄O₁₀
CFN95209	5-Hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside	942626-74-6	462.5	C₂₃H₂₆O₁₀
CFN95210	Andrographidine A	113963-37-4	462.5	C₂₃H₂₆O₁₀
CFN90833	Chrysin 7-O-beta-gentiobioside	88640-89-5	578.5	C₂₇H₃₀O₁₄
CFN99712	Oroxin A	57396-78-8	432.38	C₂₁H₂₀O₁₀
CFN99111	Baicalin	21967-41-9	446.37	C₂₁H₁₈O₁₁
CFN92283	Baicalin methyl ester	82475-03-4	460.4	C₂₂H₂₀O₁₁
CFN91993	Baicalein 7-O-beta-D-ethylglucuronide	675624-38-1	474.41	C₂₃H₂₂O₁₁
CFN92361	Baicalein 6-O-glucoside	28279-72-3	432.4	C₂₁H₂₀O₁₀
CFN99713	Oroxin B	114482-86-9	594.52	C₂₇H₃₀O₁₅