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Perforatumone
Perforatumone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Perforatumone
Price:
CAS No.: 827319-50-6
Catalog No.: CFN97317
Molecular Formula: C35H52O5
Molecular Weight: 552.8 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Source: The herbs of Hypericum henryi.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universidad de La Salle (Mexico)
  • Yale University (USA)
  • Helmholtz Zentrum München (Germany)
  • Wageningen University (Netherlands)
  • Heidelberg University (Germany)
  • Istanbul University (Turkey)
  • University of Illinois at Chicago (USA)
  • University of Toronto (Canada)
  • John Innes Centre (United Kingdom)
  • University of Wisconsin-Madison (USA)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • More...
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Perforatumone may exhibit inhibitory activities against acetylcholinesterase and human tumor cell lines.
Targets: AChR
In vitro:
J Nat Prod. 2015 Apr 24;78(4):885-95.
Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.[Pubmed: 25871261]
Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways and showing considerable structural and bioactive diversity.
METHODS AND RESULTS:
In a systematic phytochemical investigation of Hypericum henryi, 40 PPAP-type derivatives, including the new compounds hyphenrones G-Q, were obtained. These compounds represent 12 different structural types, including four unusual skeletons exemplified by 5, 8, 10, and 17. The 12 different core structures found are explicable in terms of their biosynthetic origin. The structure of a known PPAP, Perforatumone, was revised to hyphenrone A (5) by NMR spectroscopic and biomimetic synthesis methods.
CONCLUSIONS:
Several compounds exhibited inhibitory activities against acetylcholinesterase and human tumor cell lines. This study deals with the structural diversity, function, and biogenesis of natural PPAPs.
Perforatumone Description
Source: The herbs of Hypericum henryi.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.809 mL 9.0449 mL 18.0897 mL 36.1795 mL 45.2243 mL
5 mM 0.3618 mL 1.809 mL 3.6179 mL 7.2359 mL 9.0449 mL
10 mM 0.1809 mL 0.9045 mL 1.809 mL 3.6179 mL 4.5224 mL
50 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.7236 mL 0.9045 mL
100 mM 0.0181 mL 0.0904 mL 0.1809 mL 0.3618 mL 0.4522 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Emodin-8-beta-D-glucoside

Catalog No: CFN99572
CAS No: 23313-21-5
Price: $118/20mg
Borneol

Catalog No: CFN98116
CAS No: 507-70-0
Price: $30/20mg
Piperine

Catalog No: CFN99919
CAS No: 94-62-2
Price: $30/20mg
Neoeriocitrin

Catalog No: CFN92304
CAS No: 13241-32-2
Price: $188/20mg
(+)-Longifolene

Catalog No: CFN70117
CAS No: 475-20-7
Price: $30/20mg
Calenduloside E

Catalog No: CFN91169
CAS No: 26020-14-4
Price: $268/10mg
6-Prenylnaringenin

Catalog No: CFN92017
CAS No: 68236-13-5
Price: $268/10 mg
Guaiol

Catalog No: CFN96326
CAS No: 489-86-1
Price: $ / mg
Daidzin 6''-O-malonate

Catalog No: CFN91028
CAS No: 124590-31-4
Price: $318/5mg
Demethylzeylasteral

Catalog No: CFN90136
CAS No: 107316-88-1
Price: $40/20mg
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