Perforatumone | CAS:827319-50-6 | Manufacturer ChemFaces

Perforatumone

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Perforatumone may exhibit inhibitory activities against acetylcholinesterase and human tumor cell lines.

Targets:

AChR

In vitro:

J Nat Prod. 2015 Apr 24;78(4):885-95.

Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.[Pubmed: 25871261]

Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways and showing considerable structural and bioactive diversity.
METHODS AND RESULTS:
In a systematic phytochemical investigation of Hypericum henryi, 40 PPAP-type derivatives, including the new compounds hyphenrones G-Q, were obtained. These compounds represent 12 different structural types, including four unusual skeletons exemplified by 5, 8, 10, and 17. The 12 different core structures found are explicable in terms of their biosynthetic origin. The structure of a known PPAP, Perforatumone, was revised to hyphenrone A (5) by NMR spectroscopic and biomimetic synthesis methods.
CONCLUSIONS:
Several compounds exhibited inhibitory activities against acetylcholinesterase and human tumor cell lines. This study deals with the structural diversity, function, and biogenesis of natural PPAPs.

Perforatumone Description

Source:	The herbs of Hypericum henryi.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Perforatumone
Price:
CAS No.:	827319-50-6
Catalog No.:	CFN97317
Molecular Formula:	C₃₅H₅₂O₅
Molecular Weight:	552.8 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:	The herbs of Hypericum henryi.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Miscellaneous Compound Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.809 mL	9.0449 mL	18.0897 mL	36.1795 mL	45.2243 mL
5 mM	0.3618 mL	1.809 mL	3.6179 mL	7.2359 mL	9.0449 mL
10 mM	0.1809 mL	0.9045 mL	1.809 mL	3.6179 mL	4.5224 mL
50 mM	0.0362 mL	0.1809 mL	0.3618 mL	0.7236 mL	0.9045 mL
100 mM	0.0181 mL	0.0904 mL	0.1809 mL	0.3618 mL	0.4522 mL

CFN91955	Hulupinic acid	1891-42-5	264.32	C₁₅H₂₀O₄
CFN90541	Humulone	26472-41-3	362.45	C₂₁H₃₀O₅
CFN91873	Colupulone	468-27-9	400.55	C₂₅H₃₆O₄
CFN97001	8-Hydroxyhyperforin 8,1-hemiacetal	59014-02-7	552.8	C₃₅H₅₂O₅
CFN97317	Perforatumone	827319-50-6	552.8	C₃₅H₅₂O₅