| Description: |
6-Prenylnaringenin is an isomer of the potent phytoestrogen, 8-prenylnaringenin. It exhibits both mixed and non-competitive inhibitory characteristics against tyrosinase, tyrosinase is the rate-limiting enzyme for the production of melanin and other pigments via the oxidation of l-tyrosine. 6-Prenylnaringenin has anti-cancer potential , dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and UO.31 renal carcinoma cells upon treatment. 6-Prenylnaringenin can inhibit 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced inflammation (1μg/ear) in mice, it also exhibits inhibitory effects on skin-tumor promotion in anin vivo two-stagemouse-skin carcinogenesis test based on 7,12-dimethylbenz[a]- anthracene (DMBA) as initiator and with TPA as promoter. |
| In vivo: |
| Chem. Biodivers., 2012, 9(6):1045-54. | | Anti-inflammatory and anti-tumor-promoting effects of 5-deprenyllupulonol C and other compounds from Hop (Humulus lupulus L.).[Pubmed: 22700224 ] | A new phloroglucinol derivative, 5-deprenyllupulonol C (1), along with four other phloroglucinol derivatives, 2-5, five chalcones, 6-10, four flavanones, 11-14, two flavonol glycosides, 15 and 16, and five triterpenoids, 17-21, were isolated from the female inflorescence pellet extracts of hop (Humulus lupulus L.).
METHODS AND RESULTS:
Upon evaluation of these compounds against the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells, twelve compounds, i.e., 1-4, 11-14, 17-19, and 21, showed potent inhibitory effects on EBV-EA induction, with IC₅₀ values in the range of 215-393 mol ratio/32 pmol TPA. In addition, eleven compounds, i.e., 1-4, 6, 11, 12, 14, 17, 18, and 20, were found to inhibit TPA-induced inflammation (1 μg/ear) in mice, with ID₅₀ values in the range of 0.13-1.06 μmol per ear. Further, lupulone C (2) and 6-Prenylnaringenin (14) exhibited inhibitory effects on skin-tumor promotion in an in vivo two-stage mouse-skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and with TPA as promoter. |
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