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Preskimmianine
Preskimmianine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Preskimmianine
Price:
CAS No.: 38695-41-9
Catalog No.: CFN96377
Molecular Formula: C17H21NO4
Molecular Weight: 303.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The root barks of Dictamnus dasycarpus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Preskimmianine is the biogenetic precursor of skimmianine.It can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.
Targets: NO
In vitro:
J Enzyme Inhib Med Chem. 2012 Aug;27(4):490-4
Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells.[Pubmed: 21827366 ]

METHODS AND RESULTS:
The methanolic extract of Dictamnus dasycarpus root barks afforded one new glycosidic quinoline alkaloid, 3-[1β-hydroxy-2-(β-D-glucopyranosyloxy)-ethyl)-4-methoxy-2(1H)-quinolinone (1), together with nine known compounds, Preskimmianine (2), 8-methoxy-N-methylflindersine (3), dictamine (4), γ-fagarine (5), halopine (6), skimmianine (7), dictangustine-A (8), iso-γ-fagarine (9), isomaculosidine (10).
CONCLUSIONS:
The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production.
Preskimmianine Description
Source: The root barks of Dictamnus dasycarpus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

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doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.296 mL 16.4799 mL 32.9598 mL 65.9196 mL 82.3995 mL
5 mM 0.6592 mL 3.296 mL 6.592 mL 13.1839 mL 16.4799 mL
10 mM 0.3296 mL 1.648 mL 3.296 mL 6.592 mL 8.2399 mL
50 mM 0.0659 mL 0.3296 mL 0.6592 mL 1.3184 mL 1.648 mL
100 mM 0.033 mL 0.1648 mL 0.3296 mL 0.6592 mL 0.824 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Tetrahedron Letters,1972,13(22):2199-202.
Preskimmianine : The Biogenetic Precursor of Skimmianine from Dictamnus albus L[Reference: WebLink]

METHODS AND RESULTS:
From the above evidence, Preskimmianine must have the structure (1,R = CHej or II. The structure (1,R = CH,) has the same methoxyl substitution pattern as the firanoquinoline alkaloid skixmnianine (III) which has been shown to be a constituent of the whole plant Dictmus albus L. Since (1,R = CH,) would be a likely biogenetic precursor of skimmianine.
CFN95782Epicatechin 3-O-(4-O-methylgallate)108907-44-4456.4C23H20O10
CFN92335N-Methylcorydaldine6514-05-2221.3C12H15NO3
CFN92336Thalifoline21796-15-6207.2C11H13NO3
CFN95441Oleracein E1021950-79-7219.2C12H13NO3
CFN956211-Methyl-6,8-dimethoxyquinoline-2 1H-one1210820-67-9219.2C12H13NO3
CFN96376Ravenine20105-22-0243.3C15H17NO2
CFN979554-Methoxy-1-methylquinolin-2-one32262-18-3189.2C11H11NO2
CFN92352Atanine7282-19-1243.3C15H17NO2
CFN95772Flindersine523-64-8227.3C14H13NO2
CFN92735N-Methylflindersine50333-13-6241.3C15H15NO2
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