Randaiol | CAS:87562-14-9 | Manufacturer ChemFaces

Randaiol

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Description:

Randaiol is a natural product from Magnolia hypoleuca.

In vitro:

Planta Medica, 2011 , 77 (12):42.

New biphenyl derivatives and anti-inflammatory constituents from the stem bark of Magnolia officinalis[Reference: WebLink]

The stem bark of Magnolia officinalis Rehd. et Wils. (Magnoliaceae) has been used as a traditional medicine for the treatment of gastrointestinal disorders, bronchitis, and emphysema, in China, Taiwan, Japan, and Korea [1]. Chemical studies have revealed a variety of neo-lignans and alkaloids as constituents of this plant. Many of these compounds exhibit central depressant effect, muscle relaxation, and antigastric ulcer, antibacterial, antiallergic, vasorelaxant, and neurotrophic activities.
METHODS AND RESULTS:
Investigation on EtOAc-soluble fraction of the stem bark of M. officinalis has led to the isolation of three new biphenyls, 5-allyl-5'-(1-hydroxyallyloxy)biphenyl-2,2-diol (1), 5,5'-diallyl-2'-(allyloxy)biphenyl-2-ol (2), and 5,5'-diallyl-2'-(3-methylbut-2-enyloxy)biphenyl-2-ol (3), together with 12 known compounds, including four neolignans, magnolol (4), honokiol (5), (-)-monoterpenylmagnolol (6), and randainal (7), two norlignans, magnaldehyde D (8) and Randaiol (9), and six steroids, β-sitostenone (10), stigmasta-4,22-dien-3-one (11), β-sitosterol (12), stigmasterol (13), 3β-hydroxystigmast-5-en-7-one (14), and 3β-hydroxystigmasta-5,22-dien-7-one (15). The structure of new compounds (1-3) were determined through spectroscopic and MS analyses. Among the isolates, magnolol (4) and honokiol (5) exhibited potent inhibition against fMLP-induced superoxide production with IC50 values of 4.42±0.24 and 0.68±0.20μg/mL, respectively. In addition, magnolol (4) inhibited fMLP/CB-induced elastase release with an IC50 values of 1.45±0.20μg/mL.

Randaiol Description

Source:	The barks of Magnolia hypoleuca
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Phytochemistry.1983;22(2):616–617.

Biphenyls from the heartwood of taiwan sassafras.[Reference: WebLink]

Two new biphenyls, randainal and Randaiol, have been isolated from the heartwood of Taiwan sassafras in addition to the known biphenyl magnolol which was found previously in the bark of Magnolia species.
METHODS AND RESULTS:
The two biphenyls were shown to be 2,2′-dihydroxy-5-allylbiphenyl-5′-propenal and 2,2′,5′-trihydroxy-5-allylbiphenyl on the basis of chemical and spectroscopic evidence.

Chinese Traditional & Herbal Drugs, 2013 , 44 (3) :260-264.

Chemical constituents in fractions with vasoactive activity from leaves of Magnolia officinalis[Reference: WebLink]

To study the chemical constituents in the fractions with vasoactive activity from the dried leaves of Magnolia officinalis.
METHODS AND RESULTS:
The compounds were isolated from the chloroform and n-butanol fractions by various chromatographic techniques and identified by spectroscopic methods.Sixteen compounds were obtained and identified as magnolol (1), magnaldehyde B (2), Randaiol (3), syringaresinol (4), 4, 4', 5-trihydroxy-1, 1'-di-2-propenylbiphenyl (5), lariciresinol (6), (7S, 8R) syringoylglycerol (7), coniferin (8), benzylic-β-D-allopyranoside (9), afzelin (10), isorhamnetin-3-O-β-D-glucoside (11), choerospondin (12), 5, 7-dihydroxy chromone-7-O-β-D-glucoside (13), erigeside C (14), tachioside (15), and uridine (16).
CONCLUSIONS:
Compounds 5-8 are isolated from this plant for the first time, and compounds 9-16 are isolated from this genus for the first time.

Product Name	Randaiol
Price:	$333 / 5mg
CAS No.:	87562-14-9
Catalog No.:	CFN96098
Molecular Formula:	C₁₅H₁₄O₃
Molecular Weight:	242.3 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Oil
Source:	The barks of Magnolia hypoleuca
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Lignans Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1271 mL	20.6356 mL	41.2712 mL	82.5423 mL	103.1779 mL
5 mM	0.8254 mL	4.1271 mL	8.2542 mL	16.5085 mL	20.6356 mL
10 mM	0.4127 mL	2.0636 mL	4.1271 mL	8.2542 mL	10.3178 mL
50 mM	0.0825 mL	0.4127 mL	0.8254 mL	1.6508 mL	2.0636 mL
100 mM	0.0413 mL	0.2064 mL	0.4127 mL	0.8254 mL	1.0318 mL

CFN99661	Simonsinol	155709-40-3	398.5	C₂₇H₂₆O₃
CFN96079	Magnolianin	147663-91-0	827.0	C₅₄H₅₀O₈
CFN96188	Magnolignan A	93673-81-5	300.4	C₁₈H₂₀O₄
CFN96189	Magnolignan C	93697-42-8	300.4	C₁₈H₂₀O₄
CFN95076	(1S,2S)-threo-Honokitriol	1099687-80-5	316.4	C₁₈H₂₀O₅
CFN95075	Magnaldehyde B	92829-72-6	280.3	C₁₈H₁₆O₃
CFN96172	Magnaldehyde D	93753-33-4	254.3	C₁₆H₁₄O₃
CFN91033	Tetrahydromagnolol	20601-85-8	270.4	C₁₈H₂₂O₂
CFN98872	Magnolol	528-43-8	266.3	C₁₈H₁₈O₂
CFN99902	Honokiol	35354-74-6	266.34	C₁₈H₁₈O₂