Science | Nature | Cell | View More
Natural Products
Randaiol
Randaiol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Randaiol
Price: $333 / 5mg
CAS No.: 87562-14-9
Catalog No.: CFN96098
Molecular Formula: C15H14O3
Molecular Weight: 242.3 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Oil
Source: The barks of Magnolia hypoleuca
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $222.6 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Nicolaus Copernicus Uniwersity (Poland)
  • University of South Australia (Australia)
  • Universite de Lille1 (France)
  • Medical University of Gdansk (Poland)
  • Molecular Biology Institute of ... (Spain)
  • University of Auckland (New Zealand)
  • Guangzhou Institutes of Biomedi... (China)
  • Michigan State University (USA)
  • University of Ioannina (Greece)
  • University of Malaya (Malaysia)
  • Seoul National University of Sc... (Korea)
  • More...
Package
Featured Products
Astragaloside II

Catalog No: CFN99173
CAS No: 84676-89-1
Price: $50/20mg
Genistin

Catalog No: CFN90250
CAS No: 529-59-9
Price: $40/20mg
Aurantiamide

Catalog No: CFN98984
CAS No: 58115-31-4
Price: $218/5mg
Oleic acid

Catalog No: CFN94800
CAS No: 112-80-1
Price: $30/20mg
20(R)-Ginsenoside Rh2

Catalog No: CFN90340
CAS No: 112246-15-8
Price: $70/20mg
Peiminine

Catalog No: CFN99997
CAS No: 18059-10-4
Price: $60/20mg
1,5-Dicaffeoylquinic acid

Catalog No: CFN90937
CAS No: 19870-46-3
Price: $138/20mg
Delphinidin-3-O-galactoside chloride

Catalog No: CFN92037
CAS No: 28500-00-7
Price: $238/10mg
Punicalin

Catalog No: CFN98113
CAS No: 65995-64-4
Price: $218/20mg
Glycerine trioleate

Catalog No: CFN90141
CAS No: 122-32-7
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Randaiol is a natural product from Magnolia hypoleuca.
In vitro:
Planta Medica, 2011 , 77 (12):42.
New biphenyl derivatives and anti-inflammatory constituents from the stem bark of Magnolia officinalis[Reference: WebLink]
The stem bark of Magnolia officinalis Rehd. et Wils. (Magnoliaceae) has been used as a traditional medicine for the treatment of gastrointestinal disorders, bronchitis, and emphysema, in China, Taiwan, Japan, and Korea [1]. Chemical studies have revealed a variety of neo-lignans and alkaloids as constituents of this plant. Many of these compounds exhibit central depressant effect, muscle relaxation, and antigastric ulcer, antibacterial, antiallergic, vasorelaxant, and neurotrophic activities.
METHODS AND RESULTS:
Investigation on EtOAc-soluble fraction of the stem bark of M. officinalis has led to the isolation of three new biphenyls, 5-allyl-5'-(1-hydroxyallyloxy)biphenyl-2,2-diol (1), 5,5'-diallyl-2'-(allyloxy)biphenyl-2-ol (2), and 5,5'-diallyl-2'-(3-methylbut-2-enyloxy)biphenyl-2-ol (3), together with 12 known compounds, including four neolignans, magnolol (4), honokiol (5), (-)-monoterpenylmagnolol (6), and randainal (7), two norlignans, magnaldehyde D (8) and Randaiol (9), and six steroids, β-sitostenone (10), stigmasta-4,22-dien-3-one (11), β-sitosterol (12), stigmasterol (13), 3β-hydroxystigmast-5-en-7-one (14), and 3β-hydroxystigmasta-5,22-dien-7-one (15). The structure of new compounds (1-3) were determined through spectroscopic and MS analyses. Among the isolates, magnolol (4) and honokiol (5) exhibited potent inhibition against fMLP-induced superoxide production with IC50 values of 4.42±0.24 and 0.68±0.20μg/mL, respectively. In addition, magnolol (4) inhibited fMLP/CB-induced elastase release with an IC50 values of 1.45±0.20μg/mL.
Randaiol Description
Source: The barks of Magnolia hypoleuca
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Glaucoside A

Catalog No: CFN95299
CAS No: 81474-91-1
Price: $318/5mg
Quercetin-3'-glucoside

Catalog No: CFN95271
CAS No: 19254-30-9
Price: $318/10mg
trans-Psoralenoside

Catalog No: CFN95349
CAS No: N/A
Price: $318/5mg
Geissoschizine

Catalog No: CFN95566
CAS No: 439-66-7
Price: $413/5mg
Astin A

Catalog No: CFN95187
CAS No: 151201-75-1
Price: $318/10mg
Yuanhuanin

Catalog No: CFN95127
CAS No: 83133-14-6
Price: $318/5mg
trans-Cinnamoyl beta-D-glucoside

Catalog No: CFN95497
CAS No: 13080-39-2
Price: $/mg
Pinocembroside

Catalog No: CFN95444
CAS No: 75829-43-5
Price: $118/20mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1271 mL 20.6356 mL 41.2712 mL 82.5423 mL 103.1779 mL
5 mM 0.8254 mL 4.1271 mL 8.2542 mL 16.5085 mL 20.6356 mL
10 mM 0.4127 mL 2.0636 mL 4.1271 mL 8.2542 mL 10.3178 mL
50 mM 0.0825 mL 0.4127 mL 0.8254 mL 1.6508 mL 2.0636 mL
100 mM 0.0413 mL 0.2064 mL 0.4127 mL 0.8254 mL 1.0318 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry.1983;22(2):616–617.
Biphenyls from the heartwood of taiwan sassafras.[Reference: WebLink]
Two new biphenyls, randainal and Randaiol, have been isolated from the heartwood of Taiwan sassafras in addition to the known biphenyl magnolol which was found previously in the bark of Magnolia species.
METHODS AND RESULTS:
The two biphenyls were shown to be 2,2′-dihydroxy-5-allylbiphenyl-5′-propenal and 2,2′,5′-trihydroxy-5-allylbiphenyl on the basis of chemical and spectroscopic evidence.
Chinese Traditional & Herbal Drugs, 2013 , 44 (3) :260-264.
Chemical constituents in fractions with vasoactive activity from leaves of Magnolia officinalis[Reference: WebLink]
To study the chemical constituents in the fractions with vasoactive activity from the dried leaves of Magnolia officinalis.
METHODS AND RESULTS:
The compounds were isolated from the chloroform and n-butanol fractions by various chromatographic techniques and identified by spectroscopic methods.Sixteen compounds were obtained and identified as magnolol (1), magnaldehyde B (2), Randaiol (3), syringaresinol (4), 4, 4', 5-trihydroxy-1, 1'-di-2-propenylbiphenyl (5), lariciresinol (6), (7S, 8R) syringoylglycerol (7), coniferin (8), benzylic-β-D-allopyranoside (9), afzelin (10), isorhamnetin-3-O-β-D-glucoside (11), choerospondin (12), 5, 7-dihydroxy chromone-7-O-β-D-glucoside (13), erigeside C (14), tachioside (15), and uridine (16).
CONCLUSIONS:
Compounds 5-8 are isolated from this plant for the first time, and compounds 9-16 are isolated from this genus for the first time.
Astragaloside II

Catalog No: CFN99173
CAS No: 84676-89-1
Price: $50/20mg
Genistin

Catalog No: CFN90250
CAS No: 529-59-9
Price: $40/20mg
Aurantiamide

Catalog No: CFN98984
CAS No: 58115-31-4
Price: $218/5mg
Oleic acid

Catalog No: CFN94800
CAS No: 112-80-1
Price: $30/20mg
20(R)-Ginsenoside Rh2

Catalog No: CFN90340
CAS No: 112246-15-8
Price: $70/20mg
Peiminine

Catalog No: CFN99997
CAS No: 18059-10-4
Price: $60/20mg
1,5-Dicaffeoylquinic acid

Catalog No: CFN90937
CAS No: 19870-46-3
Price: $138/20mg
Delphinidin-3-O-galactoside chloride

Catalog No: CFN92037
CAS No: 28500-00-7
Price: $238/10mg
Punicalin

Catalog No: CFN98113
CAS No: 65995-64-4
Price: $218/20mg
Glycerine trioleate

Catalog No: CFN90141
CAS No: 122-32-7
Price: $30/20mg
Tags: buy Randaiol | Randaiol supplier | purchase Randaiol | Randaiol cost | Randaiol manufacturer | order Randaiol | Randaiol distributor