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Scandine Nb-oxide
Scandine Nb-oxide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Scandine Nb-oxide
Price:
CAS No.: 140701-69-5
Catalog No.: CFN89217
Molecular Formula: C21H22N2O4
Molecular Weight: 366.41 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The dried herbs of Melodinus fusiformis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Scandine Nb-oxide is a natural product from Melodinus fusiformis.
Scandine Nb-oxide Description
Source: The dried herbs of Melodinus fusiformis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7292 mL 13.6459 mL 27.2918 mL 54.5837 mL 68.2296 mL
5 mM 0.5458 mL 2.7292 mL 5.4584 mL 10.9167 mL 13.6459 mL
10 mM 0.2729 mL 1.3646 mL 2.7292 mL 5.4584 mL 6.823 mL
50 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.0917 mL 1.3646 mL
100 mM 0.0273 mL 0.1365 mL 0.2729 mL 0.5458 mL 0.6823 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chinese Traditional Patent Medicine,2012,34 (1):85-89.
Alkaloids in Melodinus fusiformis.[Reference: WebLink]
To study the alkaloids in Melodinus fusiformis.
METHODS AND RESULTS:
The dried herbs of Melodinus fusiformis were immersed with HCl,after the enchyma passes the strong ion resin,was alkalified with ammonia solution,dried,then eluting with 95% ethanol,condense to gain extraction.Silica gel,Sephadex LH-20,Rp-18 Column were used to isolate and purify the constituents,and their structures were identified by spectral analysis and their physical characters. Nine compounds were isolated from Melodinus fusiformis,and identified as tabersonine(Ⅰ),11-hydroxy-tabersonine(Ⅱ),venalstonidine(Ⅲ),pachysiphine(Ⅳ),venalstonine(Ⅴ),scandine(Ⅵ),10-hydroxy-scandine(Ⅶ),Scandine Nb-oxide(Ⅷ) and 5-methoxy-strictamine(Ⅸ).
CONCLUSIONS:
Compounds Ⅲ,Ⅳ,Ⅸ are isolated from Melodinus fusiformis for the first time,and compound Ⅸ is isolated from the plants of Melodinus for the first time.
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