3',8-Dihydroxyvestitol | CAS:122587-87-5

3',8-Dihydroxyvestitol

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Description:

3',8-Dihydroxyvestitol could serve as antiviral drugs for dengue infection.

In vitro:

Bioinformation . 2014 Jul 22;10(7):460-465.

Molecular Docking Based Screening of Plant Flavonoids as Dengue NS1 Inhibitors[Pubmed: 25187688]

Dengue infection has turned into a serious health concern globally due to its high morbidity rate and a high possibility of increase in its mortality rate on the account of unavailability of any proper treatment for severe dengue infection. The situation demands an urgent development of efficient and practicable treatment to deal with Dengue virus (DENV). Flavonoids, a class of phytochemicals present in medicinal plants, possess anti-viral activity and can be strong drug candidates against viruses. NS1 glycoprotein of Dengue virus is involved in its RNA replication and can be a strong target for screening of drugs against this virus. Current study focuses on the identification of flavonoids which can block Asn-130 glycosylation site of Dengue virus NS1 to inhibit viral replication as glycosylation of NS1 is required for its biological functioning. Molecular docking approach was used in this study and the results revealed that flavonoids have strong potential interactions with active site of NS1. Six flavonoids (Deoxycalyxin A; 3,5,7,3',4'-pentahydroxyflavonol-3-O-beta-D-galactopyranoside; (3R)-3',8-Dihydroxyvestitol; Sanggenon O; Epigallocatechin gallate; Chamaejasmin) blocked the Asn-130 glycosylation site of NS1 and could be able to inhibit the viral replication. It can be concluded from this study that these flavonoids could serve as antiviral drugs for dengue infections. Further in-vitro analyses are required to confirm their efficacy and to evaluate their drug potency.

3',8-Dihydroxyvestitol Description

Source:	The herbs of Lotus corniculatus L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	3',8-Dihydroxyvestitol
Price:	$413 / 5mg
CAS No.:	122587-87-5
Catalog No.:	CFN95384
Molecular Formula:	C₁₆H₁₆O₆
Molecular Weight:	304.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Lotus corniculatus L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2862 mL	16.4312 mL	32.8623 mL	65.7246 mL	82.1558 mL
5 mM	0.6572 mL	3.2862 mL	6.5725 mL	13.1449 mL	16.4312 mL
10 mM	0.3286 mL	1.6431 mL	3.2862 mL	6.5725 mL	8.2156 mL
50 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.3145 mL	1.6431 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.6572 mL	0.8216 mL

CFN91578	Phenoxodiol	81267-65-4	240.3	C₁₅H₁₂O₃
CFN96183	Demethylvestitol	65332-45-8	258.3	C₁₅H₁₄O₄
CFN98483	Vestitol	35878-41-2	272.3	C₁₆H₁₆O₄
CFN97016	Isosativan	60102-29-6	286.3	C₁₇H₁₈O₄
CFN89475	(-)-Sativan	41743-86-6	286.32	C₁₇H₁₈O₄
CFN96501	Sativan	71831-00-0	286.32	C₁₇H₁₈O₄
CFN95492	(R)-Mucronulatol	57128-11-7	302.3	C₁₇H₁₈O₅
CFN95386	Mucronulatol	20878-98-2	302.3	C₁₇H₁₈O₅
CFN95384	3',8-Dihydroxyvestitol	122587-87-5	304.3	C₁₆H₁₆O₆
CFN99731	Glabridin	59870-68-7	324.37	C₂₀H₂₀O₄