Selinidin | CAS:19427-82-8 | Manufacturer ChemFaces

Selinidin

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.

Targets:

TNF-α | p38MAPK | IkB | IKK

In vitro:

Biol Pharm Bull. 2008 Mar;31(3):442-8.

Selinidin suppresses IgE-mediated mast cell activation by inhibiting multiple steps of Fc epsilonRI signaling.[Pubmed: 18310907]

IgE-mediated mast cell activation is critical for development of allergic inflammation. We have recently found that Selinidin, one of the coumarin derivatives isolated from Angelica keiskei, attenuates mast cell degranulation following engagement of the high-affinity receptor for IgE (Fc epsilonRI) with IgE and antigen.
METHODS AND RESULTS:
In the present study, we investigated the effects of Selinidin on intracellular signaling and mast cell activation employing bone marrow-derived mast cells. Here, we report that Selinidin attenuates the release of beta-hexosaminidase, synthesis of leukotriene C4, and production of tumor necrosis factor-alpha without affecting IgE-Fc epsilonRI binding. Furthermore, biochemical analyses of the Fc epsilonRI-mediated signaling pathway demonstrated that Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
CONCLUSIONS:
These results suggest that this compound suppresses IgE-mediated mast cell activation by inhibiting multiple steps of FcepsilonRI-dependent signaling pathways and would be beneficial for the prevention of allergic inflammation.

Selinidin Description

Source:	The herbs of Peucedanum harry-smithii var. subglabrum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Selinidin
Price:
CAS No.:	19427-82-8
Catalog No.:	CFN90570
Molecular Formula:	C₁₉H₂₀O₅
Molecular Weight:	328.4 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The herbs of Peucedanum harry-smithii var. subglabrum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-allergy Compound Library Anti-platelet aggregation Compound Library Coumarins Compound Library TNF-α Inhibitor Library p38MAPK Inhibitor Library IKK Inhibitor Library IkB Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0451 mL	15.2253 mL	30.4507 mL	60.9013 mL	76.1267 mL
5 mM	0.609 mL	3.0451 mL	6.0901 mL	12.1803 mL	15.2253 mL
10 mM	0.3045 mL	1.5225 mL	3.0451 mL	6.0901 mL	7.6127 mL
50 mM	0.0609 mL	0.3045 mL	0.609 mL	1.218 mL	1.5225 mL
100 mM	0.0305 mL	0.1523 mL	0.3045 mL	0.609 mL	0.7613 mL

CFN96394	Khellactone	24144-61-4	262.3	C₁₄H₁₄O₅
CFN89413	cis-Methylkhellactone	20107-13-5	276.28	C₁₅H₁₆O₅
CFN96695	Praeroside II	86940-46-7	424.40	C₂₀H₂₄O₁₀
CFN95881	Qianhucoumarin D	20516-19-2	346.3	C₁₈H₁₈O₇
CFN91656	Visnadine	477-32-7	388.41	C₂₁H₂₄O₇
CFN96375	Samidin	477-33-8	386.4	C₂₁H₂₂O₇
CFN95841	Suksdorfin	53023-17-9	388.4	C₂₁H₂₄O₇
CFN89402	Hyuganin D	77331-76-1	374.38	C₂₀H₂₂O₇
CFN89386	(-)-Praeruptorin A	14017-71-1	386.39	C₂₁H₂₂O₇
CFN98143	Praeruptorin C	72463-77-5	428.48	C₂₄H₂₈O₇