Sinigrin | CAS:3952-98-5 | Manufacturer ChemFaces

Sinigrin

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $18.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Sinigrin has antimicrobial activity. Sinigrin also exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats.

Targets:

p53 | Bcl-2/Bax | Caspase | Antifection

In vitro:

Lett Appl Microbiol. 2015 May 15.

Use of a nanoparticulate carboxymethyl cellulose film containing sinigrin as an antimicrobial precursor to kill Escherichia coli O157:H7 on fresh beef.[Pubmed: 25976711]

METHODS AND RESULTS:
Nanocomposite carboxymethyl cellulose films containing Sinigrin (SNG) were prepared by stirring 2% (w/v) carboxymethyl cellulose (CMC) and 2% (w/v) glycerol (as a plasticizer) in distilled water with or without SNG (an antimicrobial precursor) as a 99% pure reagent (pSNG) or as a crude extract (cSNG). These films plus normal CMC film with or without SNG were tested on Escherichia coli O157:H7- inoculated beef for antimicrobial activity. Beef pieces measuring 6 × 5 × 2 cm(3) (L × W × H) were dipped in an E. coli O157:H7 broth suspension containing >8 log10 CFU ml(-1) and were drained for 3 min over a sterile cloth. They were wrapped in CMC or NCMC films, placed in a high oxygen barrier film (Deli *1), vacuum-packaged and stored at 8°C for 5, 8, 12 and 18 days.
CONCLUSIONS:
The CMC and NCMC films without SNG were not antimicrobial against E. coli O157:H7; however, NCMC and CMC films with SNG were highly antimicrobial. After 5 days at 8°C, E. coli O157:H7 was reduced more than 4 log10 by the NCMC•pSNG film and this reduction remained almost the same until 18 days at 8°C when E. coli O157:H7 was reduced >5 log10 CFU g(-1) meat.

In vivo:

PLoS One. 2014 Oct 20;9(10):e110145.

Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats.[Pubmed: 25329483]

Liver cancer is one of the leading causes of cancer death worldwide. A very high incidence of new liver cancer cases is diagnosed every year, and metastasis has been found to correlate to poor prognoses in humans. Better treatments for liver cancer are thus clearly needed. Sinigrin is one of the major ingredients present in Brassica nigra, which has been used in combination with other herbs for treatment of various diseases.
METHODS AND RESULTS:
The anti-proliferative activities of Sinigrin were studied in a model of carcinogen-induced hepatotoxicity in rats. Rats were orally administered with Sinigrin on a daily basis for three months before sacrifice. Sinigrin was found to significantly inhibit the proliferation of liver tumor cells; the number of surface tumors in the rat liver was dramatically reduced. Sinigrin induced apoptosis of liver cancer cells through up-regulation of p53 and down-regulation of Bcl-2 family members and caspases. Our findings indicated that the liver functions were gradually restored after treatment with Sinigrin and that the agent did not cause liver toxicity. Cell cycle analysis indicated that Sinigrin caused cell cycle arrest in G0/G1 phase.
CONCLUSIONS:
The results suggest that Sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats, and highlight the potential of Sinigrin as an anti-cancer agent for liver cancer.

Sinigrin Description

Source:	The seeds of Lepidium apetalum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Sinigrin
Price:	$80 / 20mg
CAS No.:	3952-98-5
Catalog No.:	CFN90453
Molecular Formula:	C₁₀H₁₆KNO₉S₂
Molecular Weight:	397.5 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The seeds of Lepidium apetalum
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Phagostimulants Compound Library Mutagenic Compound Library Alkaloids Compound Library p53 Inhibitor Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5157 mL	12.5786 mL	25.1572 mL	50.3145 mL	62.8931 mL
5 mM	0.5031 mL	2.5157 mL	5.0314 mL	10.0629 mL	12.5786 mL
10 mM	0.2516 mL	1.2579 mL	2.5157 mL	5.0314 mL	6.2893 mL
50 mM	0.0503 mL	0.2516 mL	0.5031 mL	1.0063 mL	1.2579 mL
100 mM	0.0252 mL	0.1258 mL	0.2516 mL	0.5031 mL	0.6289 mL

CFN00499	Glucoalyssin	499-37-6	489.6	C₁₃H₂₄KNO₁₀S₃
CFN00480	Glucohesperin	33049-17-1	503.7	C₁₄H₂₆KNO₁₀S₃
CFN00498	Glucohirsutin	21973-60-4	531.7	C₁₆H₃₀KNO₁₀S₃
CFN00502	Glucoarabin	67920-64-3	545.7	C₁₇H₃₂KNO₁₀S₃
CFN00501	Glucocamelinin	67884-10-0	559.8	C₁₈H₃₄KNO₁₀S₃
CFN00506	11-(Methylsulfinyl)undecylglucosinolate	N/A	573.8	C₁₉H₃₆KNO₁₀S₃
CFN00492	Gluconapin	245550-57-6	411.5	C₁₁H₁₈KNO₉S₂
CFN00507	Epiprogoitrin	21087-74-1	427.5	C₁₁H₁₈KNO₁₀S₂
CFN00508	Progoitrin	21087-77-4	427.5	C₁₁H₁₈KNO₁₀S₂
CFN00485	Glucocapparin	15592-33-3	371.4	C₈H₁₄KNO₉S₂