Sotetsuflavone | CAS:2608-21-1 | Manufacturer ChemFaces

Sotetsuflavone

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Size /Price /Stock	10 mM * 1 mL in DMSO / $423.2 / In-stock
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Description:

Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 uM, is the most active compound of this series.

Targets:

DENV-NS5 RdRp

In vitro:

Planta Med. 2013 Sep;79(14):1313-8.

Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.[Pubmed: 23929244 ]

Dengue virus is the world's most prevalent human pathogenic arbovirus. There is currently no treatment or vaccine, and solutions are urgently needed. We previously demonstrated that biflavonoids from Dacrydium balansae, an endemic gymnosperm from New Caledonia, are potent inhibitors of the Dengue virus NS5 RNA-dependent RNA polymerase.
METHODS AND RESULTS:
Herein we describe the structure-activity relationship study of 23 compounds: biflavonoids from D. balansae (1-4) and from D. araucarioides (5-10), hexamethyl-amentoflavone (11), cupressuflavone (12), and apigenin derivatives (13-23). We conclude that 1) over the four different biflavonoid skeletons tested, amentoflavone (1) and robustaflavone (5) are the most promising ones for antidengue drug development, 2) the number and position of methyl groups on the biflavonoid moiety modulate their inhibition of Dengue virus NS5 RNA-dependent RNA polymerase, and 3) the degree of oxygenation of flavonoid monomers influences their antidengue potential.
CONCLUSIONS:
Sotetsuflavone (8), with an IC50 = 0.16 μM, is the most active compound of this series and is the strongest inhibitor of the Dengue virus NS5 RNA-dependent RNA polymerase described in the literature.

Sotetsuflavone Description

Source:	The herbs of Selaginella tamariscina
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Nat Prod. 2003 Jul;66(7):1002-5.

Chemical constituents from Amentotaxus yunnanensis and Torreyayunnanensis.[Pubmed: 12880325 ]

In a chemical study of taxonomically related Taxaceae plants of Yunnan Province, China, seven compounds, including a new amentoflavone biflavonoid, 2,3-dihydro-7,7' '-dimethoxyamentoflavone (1), were isolated from Amentotaxus yunnanensis, and 12 isolates were obtained from Torreya yunnanensis. From the latter plant, a new abietane diterpene, torreyayunnin (7), is reported for the first time.
METHODS AND RESULTS:
The known isolates from A. yunnanensis have been identified as sequoiaflavone (3), Sotetsuflavone (4), 7,7' '-dimethoxyamentoflavone (5), lutein, beta-sitosterol, and sequoyitol. Amentoflavone (2), Sotetsuflavone (4), sciadopitysin (6), 12-hydroxydehydroabietinol, meridinol, balanophonin, (+)-pinoresinol monomethyl ether, (+)-pinoresinol monomethyl ether glucoside, erythro-1-(4-hydroxy-3-methoxyphenyl)-2-[4-[2-formyl-(E)-vinyl]-2- methoxyphenoxy]propane-1,3-diol, threo-1-(4-hydroxy-3-methoxyphenyl)-2- [4-[2-formyl-(E)-vinyl]-2-methoxyphenoxy] propane-1,3-diol, and (E)-2-butenedioic acid were identified as known isolates from T. yunnanensis.
CONCLUSIONS:
The presence of the amentoflavone biflavonoids (1, 3-5) in A. yunnanensis supports its placement in the Taxaceae. The occurrence of the biflavonoid Sotetsuflavone (4) in both A. yunnanensis and T. yunnanensis suggests that these two genera are closely related. The identification and structural elucidation of these isolates were based on spectral data analysis including 1D and 2D NMR.

Product Name	Sotetsuflavone
Price:	$368 / 5mg
CAS No.:	2608-21-1
Catalog No.:	CFN93257
Molecular Formula:	C₃₁H₂₀O₁₀
Molecular Weight:	552.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The herbs of Selaginella tamariscina
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Antiviral Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.81 mL	9.0498 mL	18.0995 mL	36.1991 mL	45.2489 mL
5 mM	0.362 mL	1.81 mL	3.6199 mL	7.2398 mL	9.0498 mL
10 mM	0.181 mL	0.905 mL	1.81 mL	3.6199 mL	4.5249 mL
50 mM	0.0362 mL	0.181 mL	0.362 mL	0.724 mL	0.905 mL
100 mM	0.0181 mL	0.0905 mL	0.181 mL	0.362 mL	0.4525 mL

CFN89133	GB 2a	18412-96-9	558.49	C₃₀H₂₂O₁₁
CFN92960	Wikstrol A	159736-35-3	542.49	C₃₀H₂₂O₁₀
CFN70356	Cupressuflavone	3952-18-9	538.5	C₃₀H₁₈O₁₀
CFN97224	4',4'''-Di-O-methylcupressuflavone	74336-91-7	566.5	C₃₂H₂₂O₁₀
CFN95007	8,8''-Bibaicalein	135309-02-3	538.5	C₃₀H₁₈O₁₀
CFN96555	Acuminatanol	948884-38-6	638.49	C₃₀H₂₂O₁₆
CFN95766	Isoacuminatanol	2446349-77-3	638.5	C₃₀H₂₂O₁₆
CFN96163	2,3-Dihydroamentoflavone 7,4'-dimethyl ether	873999-88-3	568.5	C₃₂H₂₄O₁₀
CFN96119	2,3-Dihydroheveaflavone	110382-42-8	582.6	C₃₃H₂₆O₁₀
CFN96134	2,3-dihydrosciadopitysin	34421-19-7	582.6	C₃₃H₂₆O₁₀