Soyasaponin Bd | CAS:135272-91-2 | Manufacturer ChemFaces

Soyasaponin Bd

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Description:

1. Soyasaponins has chemoprevention activities, it prevent H₂O₂-induced inhibition of gap junctional intercellular communication by scavenging reactive oxygen species in rat liver cells.
2. Soyasaponins can significantly decrease blood glucose, improve atherosclerotic index, and inhibit lipid peroxidation and platelet aggregation in diabetic rats, which may be useful in prevention and control of diabetes mellitus and diabetes-associated atherosclerosis.
3. Soyasaponins abundant in soybean have anti-inflammatory activities, low-dose SSs alleviated contact hypersensitivity (CHS) symptoms by attenuating inflammation and improving the intestinal microbiota composition, suggesting that dietary SSs may have beneficial effects on allergic contact dermatitis (ACD).
4. Dietary soyasaponin has inhibitory effects on 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice.

Targets:

ROS | Immunology & Inflammation related

In vitro:

J Enzyme Inhib Med Chem . 2019 Dec;34(1):350-360.

Soyasaponins from Zolfino bean as aldose reductase differential inhibitors[Pubmed: 30734590]

Abstract Seven triterpenoid saponins were identified in methanolic extracts of seeds of the Zolfino bean landrace (Phaseolus vulgaris L.) by HPLC fractionation, revealing their ability to inhibit highly purified human recombinant aldose reductase (hAKR1B1). Six of these compounds were associated by MS analysis with the following saponins already reported in different Phaseolus vulgaris varieties: soyasaponin Ba (V), soyasaponin Bb, Soyasaponin Bd (sandosaponin A), soyasaponin αg, 3-O-[R-l-rhamnopyranosyl(1 → 2)-α-d-glucopyranosyl(1 → 2)-α-d-glucuronopyranosyl]olean-12-en-22-oxo-3α,-24-diol, and soyasaponin βg. The inhibitory activity of the collected fractions containing the above compounds was tested for hAKR1B1-dependent reduction of both l-idose and 4-hydroxynonenal, revealing that some are able to differentially inhibit the enzyme. The present work also highlights the difficulties in the search for aldose reductase differential inhibitors (ARDIs) in mixtures due to the masking effect on ARDIs exerted by the presence of conventional aldose reductase inhibitors. The possibility of differential inhibition generated by a different inhibitory model of action of molecules on different substrates undergoing transformation is also discussed. Keywords: Saponins; Zolfino bean; aldose reductase; differential inhibitors.

Soyasaponin Bd Description

Source:	The seeds of Glycine max
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Food Chemistry, 2014, 146:270-277.

Rapid characterisation and comparison of saponin profiles in the seeds of Korean Leguminous species using ultra performance liquid chromatography with photodiode array detector and electrospray ionisation/mass spectrometry (UPLC-PDA-ESI/MS) analysis.[Reference: WebLink]

METHODS AND RESULTS:
The present work was reported on investigation of saponin profiles in nine different legume seeds, including soybean, adzuki bean, cowpea, common bean, scarlet runner bean, lentil, chick pea, hyacinth bean, and broad bean using ultra performance liquid chromatography with photodiode array detector and electrospray ionisation/mass spectrometry (UPLC-PDA-ESI/MS) technique. A total of twenty saponins were characterised under rapid and simple conditions within 15min by the 80% methanol extracts of all species. Their chemical structures were elucidated as soyasaponin Ab (1), soyasaponin Ba (2), soyasaponin Bb (3), soyasaponin Bc (4), Soyasaponin Bd (5), soyasaponin αg (6), soyasaponin βg (7), soyasaponin βa (8), soyasaponin γg (9), soyasaponin γa (10), azukisaponin VI (11), azukisaponin IV (12), azukisaponin II (13), AzII (14), AzIV (15), lablaboside E (16), lablaboside F (17), lablaboside D (18), chikusetusaponin IVa (19), and lablab saponin I (20).
CONCLUSIONS:
The individual and total saponin compositions exhibited remarkable differences in all legume seeds. In particular, soyasaponin βa (8) was detected the predominant composition in soybean, cowpea, and lentil with various concentrations. Interestingly, soybean, adzuki bean, common bean, and scarlet runner bean had high saponin contents, while chick pea and broad bean showed low contents.

Product Name	Soyasaponin Bd
Price:
CAS No.:	135272-91-2
Catalog No.:	CFN90775
Molecular Formula:	C₄₈H₇₆O₁₉
Molecular Weight:	957.1 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The seeds of Glycine max
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antioxidants Compound Library Anti-allergy Compound Library Anti-Atherosclerotic Compound Library Dietary supplement Compound Library Anti-diabetic Compound Library Cancer chemoprevention Compound Library Anticoagulants Compound Library Triterpenoids Compound Library ROS Inhibitor Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0448 mL	5.2241 mL	10.4482 mL	20.8965 mL	26.1206 mL
5 mM	0.209 mL	1.0448 mL	2.0896 mL	4.1793 mL	5.2241 mL
10 mM	0.1045 mL	0.5224 mL	1.0448 mL	2.0896 mL	2.6121 mL
50 mM	0.0209 mL	0.1045 mL	0.209 mL	0.4179 mL	0.5224 mL
100 mM	0.0104 mL	0.0522 mL	0.1045 mL	0.209 mL	0.2612 mL

CFN90775	Soyasaponin Bd	135272-91-2	957.1	C₄₈H₇₆O₁₉
CFN93251	Soyasaponin IV	108906-97-4	767.0	C₄₁H₆₆O₁₃
CFN91596	Soyasaponin III	55304-02-4	796.99	C₄₂H₆₈O₁₄
CFN93159	Soyasaponin II	55319-36-3	913.1	C₄₇H₇₆O₁₇
CFN90456	Soyasaponin Bb	51330-27-9	943.12	C₄₈H₇₈O₁₈
CFN90722	Soyasaponin Ba	114590-20-4	959.1	C₄₈H₇₈O₁₉
CFN90455	Soyasaponin Aa	117230-33-8	1365.46	C₆₄H₁₀₀O₃₁
CFN90773	Soyasaponin Ab	118194-13-1	1437.6	C₆₇H₁₀₄O₃₃
CFN90774	Soyasaponin Ac	133882-74-3	1421.6	C₆₇H₁₀₄O₃₂
CFN80325	Pedunsaponin C	272120-53-3	795.0	C₄₂H₆₆O₁₄