Stigmast-4-ene-3,6-dione | CAS:23670-94-2

Stigmast-4-ene-3,6-dione

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Description:

Stigmast-4-ene-3,6-dione has anti-inflammatory and anti-allergic properties.

Targets:

Immunology & Inflammation related

In vitro:

Chem Pharm Bull (Tokyo). 2005 May;53(5):561-4.

Antimutagenic constituents from the thorns of Gleditsia sinensis[Pubmed: 15863930]

METHODS AND RESULTS:
Antimutagenic activity-guided fractionation of an extract prepared from the thorns of Gleditsia sinensis LAM. led to the isolation of one triterpenoid and four steroids, which were identified as D:C-friedours-7-en-3-one (1), Stigmast-4-ene-3,6-dione (2), stigmastane-3,6-dione (3), stigmasterol (4), and beta-sitosterol (5). Triterpenoid 1 was found for the first time in a natural source and the steroids 2-5 were first isolated from this plant.
CONCLUSIONS:
Stigmasterol was the most active antimutagen, showing 51.2% and 64.2% reduction of the induction factor against the mutagens MNNG and NQO, respectively, in the SOS chromotest. Some NMR data of the steroids 2 and 3 obtained have to be revised.

Stigmast-4-ene-3,6-dione Description

Source:	The roots of Echium vulgare L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Phytochemistry. 1998 Nov;49(6):1663-6.

Constituents and bioactive principles of Polygonum chinensis.[Pubmed: 9862141]

Isolation and characterization of the chemical constituents of Polygonum chinensis L. gave the new 25R-spirost-4-ene-3,12-dione. The known compounds Stigmast-4-ene-3,6-dione, stigmastane-3,6-dione, hecogenin and aurantiamide acetate were also isolated from for the first time from this species. Their anti-inflammatory and anti-allergic properties are described.

J Nat Prod. 2005 Feb;68(2):285-8.

Antioxidative constituents of Etlingera elatior.[Pubmed: 15730265 ]

METHODS AND RESULTS:
Phytochemical studies on the rhizomes of Etlingera elatior have resulted in the isolation of 1,7-bis(4-hydroxyphenyl)-2,4,6-heptatrienone (1), demethoxycurcumin (2), 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (3), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (4), stigmast-4-en-3-one, Stigmast-4-ene-3,6-dione, stigmast-4-en-6beta-ol-3-one, and 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol.
CONCLUSIONS:
Compounds 1 and 4 are new, and their structures were elucidated by analysis of spectroscopic data. Diarylheptanoids 1-3 were found to inhibit lipid peroxidation in a more potent manner than alpha-tocopherol.

Product Name	Stigmast-4-ene-3,6-dione
Price:
CAS No.:	23670-94-2
Catalog No.:	CFN98968
Molecular Formula:	C₂₉H₄₆O₂
Molecular Weight:	426.7 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Cryst.
Source:	The roots of Echium vulgare L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Anti-allergy Compound Library Steroids Compound Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3436 mL	11.7178 mL	23.4357 mL	46.8713 mL	58.5892 mL
5 mM	0.4687 mL	2.3436 mL	4.6871 mL	9.3743 mL	11.7178 mL
10 mM	0.2344 mL	1.1718 mL	2.3436 mL	4.6871 mL	5.8589 mL
50 mM	0.0469 mL	0.2344 mL	0.4687 mL	0.9374 mL	1.1718 mL
100 mM	0.0234 mL	0.1172 mL	0.2344 mL	0.4687 mL	0.5859 mL

CFN99220	Stigmastane-3,6-diol	112244-29-8	432.7	C₂₉H₅₂O₂
CFN98206	Stigmastane-3,6-dione	22149-69-5	428.7	C₂₉H₄₈O₂
CFN98048	Stigmastane-3,5,6-triol	20835-91-0	448.7	C₂₉H₅₂O₃
CFN97930	Stigmasta-4,22-diene-3beta,6beta-diol	167958-89-6	428.7	C₂₉H₄₈O₂
CFN99234	Stigmast-4-ene-3,6-diol	113626-76-9	430.7	C₂₉H₅₀O₂
CFN98495	6-Hydroxystigmasta-4,22-dien-3-one	36450-01-8	426.7	C₂₉H₄₆O₂
CFN98496	6beta-Hydroxystigmast-4-en-3-one	36450-02-9	428.7	C₂₉H₄₈O₂
CFN98968	Stigmast-4-ene-3,6-dione	23670-94-2	426.7	C₂₉H₄₆O₂
CFN98594	Cyasterone	17086-76-9	520.65	C₂₉H₄₄O₈
CFN90613	Precyasterone	27335-85-9	520.65	C₂₉H₄₄O₈