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Stilbostemin B
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Product Name Stilbostemin B
Price:
CAS No.: 162411-67-8
Catalog No.: CFN97810
Molecular Formula: C15H16O2
Molecular Weight: 228.29 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The roots of Stemona sessilifolia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Stilbostemin A, stilbostemin B , stilbostemin D , stilbostemin F , and stilbostemin G show structure-dependent inhibition of leukotriene biosynthesis with IC(50) values ranging from 3.7 to >50 microM.
In vitro:
J Nat Prod. 2005 Jan;68(1):83-5.
Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species.[Pubmed: 15679323 ]

METHODS AND RESULTS:
Fifteen stilbenoids and two alkaloids from Stemona collinsae, S. tuberosa, and S. peirrei were tested alongside the commercially available stilbenoids resveratrol and pinosylvin for inhibition of leukotriene formation in an ex vivo test system based on activated human neutrophilic granulocytes.
CONCLUSIONS:
The stilbenoids resveratrol (1), pinosylvin (2), dihydropinosylvin (3), stilbostemin A (4), Stilbostemin B (5), stilbostemin D (6), stilbostemin F (7), stilbostemin G (8), stemofuran B (9), stemofuran C (10), stemofuran D (11), stemofuran G (12), stemofuran J (13), stemanthrene A (14), stemanthrene B (15), stemanthrene C (16), and stemanthrene D (17) showed structure-dependent activities with IC(50) values ranging from 3.7 to >50 microM. The alkaloids tuberostemonine (18) and neotuberostemonine (19) were inactive at a concentration of 50 microM.
Stilbostemin B Description
Source: The roots of Stemona sessilifolia
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

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doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.3804 mL 21.902 mL 43.8039 mL 87.6079 mL 109.5098 mL
5 mM 0.8761 mL 4.3804 mL 8.7608 mL 17.5216 mL 21.902 mL
10 mM 0.438 mL 2.1902 mL 4.3804 mL 8.7608 mL 10.951 mL
50 mM 0.0876 mL 0.438 mL 0.8761 mL 1.7522 mL 2.1902 mL
100 mM 0.0438 mL 0.219 mL 0.438 mL 0.8761 mL 1.0951 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2014 Feb;39(4):695-8.
Chemical constituents from Glechoma longituba.[Pubmed: 25204149]
Fourteen compounds were obtained from Glechoma longituba by the chromatographic methods of silica gel,ODS,Sephadex LH-20 and preparative of HPLC.
METHODS AND RESULTS:
According to physicochemical properties and spectral data,these compounds were identified as Stilbostemin B(l),trilepisiumic acid(2),3,4-dihydroxyphenyl ethanol ketone(3),bergeninmonohydrate(4),oresbiusin A(5),norbergenin(6),stilbostemin D(7),ehretioside B(8),ethyl ferulate(9),E-p-hydroxy-cinnamic acid(10),methyl gallate(ll),protocalechuic acid(12),4'-Hydroxyacetophenone(13),and E-3-2,4-dihydroxyphenyl-2-acrylic acid(14).
CONCLUSIONS:
Among them,compounds1-10,13 and 14 were isolated from this plant for the first time.
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