(-)-Syringaresinol | CAS:6216-81-5 | Manufacturer ChemFaces

(-)-Syringaresinol

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $154.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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(-)-Syringaresinol Description

Source:	The rhizomes of Polygonatum kingianum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Int Immunopharmacol. 2008 Jul;8(7):967-73.

(-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis.[Pubmed: 18486907]

We examined the effect of (-)-Syringaresinol, a furofuran-type lignan isolated from Daphne genkwa, on cell cycle regulation in HL-60 human promyelocytic leukemia cells in vitro.
METHODS AND RESULTS:
(-)-Syringaresinol decreased the viability of HL-60 cells by inducing G(1) arrest followed by apoptosis in a dose- and time-dependent manner. The G(0)/G(1) phase of the cell cycle is regulated by cyclin-dependent kinases (Cdk), cyclins and cyclin-dependent kinase inhibitors (Cdki). We show by western blot analysis, that the (-)-Syringaresinol-induced G(1) arrest was mediated through the increased expression of Cdki proteins (p21(cip1/waf1) and p27(kip1)) with a simultaneous decrease in cdk2, cdk4, cdk6, cyclin D(1), cyclin D(2), and cyclin E expression. The induction of apoptosis after treatment with (-)-Syringaresinol for 24 h was demonstrated by morphological changes, DNA fragmentation, altered ratio of Bax/Bcl-2, cleavage of poly(ADP-ribose) polymerase and flow cytometry analysis. (-)-Syringaresinol also induced cytochrome c release and activation of caspase-3 and caspase-9. To our knowledge, this is the first time that (-)-Syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis.
CONCLUSIONS:
These findings suggest that (-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer.

Product Name	(-)-Syringaresinol
Price:	$268 / 10mg
CAS No.:	6216-81-5
Catalog No.:	CFN92500
Molecular Formula:	C₂₂H₂₆O₈
Molecular Weight:	418.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The rhizomes of Polygonatum kingianum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Chemotherapeutic agents Compound Library Lignans Compound Library PARP Inhibitor Library P450 (e.g. CYP17) Inhibitor Library p21 Inhibitor Library CDK Inhibitor Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library

Description:	(-)-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis, may be a potential chemotherapeutic agent for the treatment of cancer.
Targets:	Cdk \| p21 \| Bcl-2/Bax \| Caspase \| PARP \| P450 (e.g. CYP17)

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3901 mL	11.9503 mL	23.9006 mL	47.8011 mL	59.7514 mL
5 mM	0.478 mL	2.3901 mL	4.7801 mL	9.5602 mL	11.9503 mL
10 mM	0.239 mL	1.195 mL	2.3901 mL	4.7801 mL	5.9751 mL
50 mM	0.0478 mL	0.239 mL	0.478 mL	0.956 mL	1.195 mL
100 mM	0.0239 mL	0.1195 mL	0.239 mL	0.478 mL	0.5975 mL

CFN97877	Hedyotisol B	95839-45-5	810.9	C₄₂H₅₀O₁₆
CFN99504	(-)-Syringaresinol 4-(2''-apiosylglucoside)	136997-64-3	712.69	C₃₃H₄₄O₁₇
CFN92288	(+)-Epipinoresinol	24404-50-0	358.4	C₂₀H₂₂O₆
CFN89280	Kobusin	36150-23-9	370.40	C₂₁H₂₂O₆
CFN90144	(-)-Asarinin	133-04-0	354.35	C₂₀H₁₈O₆
CFN92420	(-)-Epipinoresinol	10061-38-8	358.4	C₂₀H₂₂O₆
CFN90511	Phillygenin	487-39-8	372.41	C₂₁H₂₄O₆
CFN99998	Phillyrin	487-41-2	534.56	C₂₇H₃₄O₁₁
CFN95918	Styraxlignolide G	N/A	534.6	C₂₇H₃₄O₁₁
CFN91840	(+)-Mediresinol Di-O-beta-D-glucopyranoside	88142-63-6	712.7	C₃₃H₄₄O₁₇