Science | Nature | Cell | View More
Natural Products
Tabersonine
Tabersonine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Tabersonine
Price: $80 / 20mg
CAS No.: 4429-63-4
Catalog No.: CFN98678
Molecular Formula: C21H24N2O2
Molecular Weight: 336.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Yellow powder
Source: The root barks of Voacanga africana Stapf
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $14.4 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universidade Federal de Goias (... (Brazil)
  • Heinrich-Heine-University Düss... (Germany)
  • Deutsches Krebsforschungszentrum (Germany)
  • Institute of Pathophysiology Me... (Austria)
  • University of Pretoria (South Africa)
  • University of Limpopo (South Africa)
  • Indian Institute of Science (India)
  • National Research Council of Ca... (Canada)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Bonn (Germany)
  • More...
Package
Featured Products
Narcissoside

Catalog No: CFN99773
CAS No: 604-80-8
Price: $70/20mg
Arctiin

Catalog No: CFN99991
CAS No: 20362-31-6
Price: $30/20mg
Eurycomanone

Catalog No: CFN92008
CAS No: 84633-29-4
Price: $268/20mg
Artesunate

Catalog No: CFN90313
CAS No: 88495-63-0
Price: $30/20mg
Myrcene

Catalog No: CFN70046
CAS No: 123-35-3
Price: $30/20mg
Aurantiamide

Catalog No: CFN98984
CAS No: 58115-31-4
Price: $218/5mg
Rebaudioside F

Catalog No: CFN95215
CAS No: 438045-89-7
Price: $268/5mg
Morroniside

Catalog No: CFN98161
CAS No: 25406-64-8
Price: $50/20mg
Catechin

Catalog No: CFN99646
CAS No: 154-23-4
Price: $30/20mg
Cannabidiol

Catalog No: CFN99444
CAS No: 13956-29-1
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Tabersonine is a precursor for vincristine used in cancer chemotherapy, the biocompatibility and small size essential for permeating the blood-brain barrier make it a potential therapeutic drug candidate for treating AD.
Targets: Beta Amyloid | P450 (e.g. CYP17)
In vitro:
ACS Chem Neurosci. 2015 Jun 17;6(6):879-88.
Tabersonine Inhibits Amyloid Fibril Formation and Cytotoxicity of Aβ(1-42).[Pubmed: 25874995 ]
The misfolding and aggregation of amyloid beta (Aβ) peptides into amyloid fibrils are key events in the amyloid cascade hypothesis for the etiology of Alzheimer's disease (AD).
METHODS AND RESULTS:
Using thioflavin-T (ThT) fluorescence assay, atomic force microscopy, circular dichroism, size exclusion chromatography, surface plasmon resonance (SPR), and cytotoxicity tests, we demonstrate that Tabersonine, an ingredient extracted from the bean of Voacanga africana, disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. A small amount of Tabersonine (e.g., 10 μM) can effectively inhibit the formation of Aβ(1-42) (e.g., 80 μM) fibrils or convert mature fibrils into largely innocuous amorphous aggregates. SPR results indicate that Tabersonine binds to Aβ(1-42) oligomers in a dose-dependent way. Molecular dynamics (MD) simulations further confirm that Tabersonine can bind to oligomers such as the pentamer of Aβ(1-42). Tabersonine preferentially interact with the β-sheet grooves of Aβ(1-42) containing aromatic and hydrophobic residues. The various binding sites and modes explain the diverse inhibitory effects of Tabersonine on Aβ aggregation.
CONCLUSIONS:
Given that Tabersonine is a natural product and a precursor for vincristine used in cancer chemotherapy, the biocompatibility and small size essential for permeating the blood-brain barrier make it a potential therapeutic drug candidate for treating AD.
Phytochemistry. 2003 Sep;64(2):401-9.
Jasmonate-induced epoxidation of tabersonine by a cytochrome P-450 in hairy root cultures of Catharanthus roseus.[Pubmed: 12943756]
Methyl jasmonate, a chemical inducer of secondary metabolism, was shown to promote Tabersonine 2 biosynthesis in hairy root cultures of Catharanthus roseus.
METHODS AND RESULTS:
Tabersonine 6,7-epoxidase activity was detected in total protein extract of jasmonate-induced hairy root cultures using labeled 14C-Tabersonine 2. This enzyme converted Tabersonine 2 to lochnericine 3 by selective epoxidation at positions 6 and 7 via a reaction dependent on NADPH and molecular oxygen. Carbon monoxide, clotrimazole, miconazole, and cytochrome C were shown to be strong inhibitors of the enzyme.
CONCLUSIONS:
The activity was found in microsomes, indicating that Tabersonine 6,7-epoxidase was a cytochrome P-450-dependent monooxygenase.
Tabersonine Description
Source: The root barks of Voacanga africana Stapf
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
2',4'-Dihydroxychalcone

Catalog No: CFN95493
CAS No: 1776-30-3
Price: $318/20mg
Safflospermidine B

Catalog No: CFN95254
CAS No: N/A
Price: $413/5mg
Notoginsenoside L13

Catalog No: CFN95332
CAS No: 2485859-56-9
Price: $318/5mg
Aegineoside

Catalog No: CFN95270
CAS No: 752209-48-6
Price: $413/5mg
Planispine A

Catalog No: CFN95348
CAS No: 1202761-42-9
Price: $318/10mg
Fragransin B1

Catalog No: CFN95443
CAS No: 112516-03-7
Price: $318/5mg
Ganoderic acid L

Catalog No: CFN95022
CAS No: 102607-24-9
Price: $413/5mg
11-Keto-ganoderic acid DM

Catalog No: CFN95593
CAS No: N/A
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9727 mL 14.8633 mL 29.7265 mL 59.453 mL 74.3163 mL
5 mM 0.5945 mL 2.9727 mL 5.9453 mL 11.8906 mL 14.8633 mL
10 mM 0.2973 mL 1.4863 mL 2.9727 mL 5.9453 mL 7.4316 mL
50 mM 0.0595 mL 0.2973 mL 0.5945 mL 1.1891 mL 1.4863 mL
100 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.5945 mL 0.7432 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Proc Natl Acad Sci U S A. 2015 May 12;112(19):6224-9.
Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast.[Pubmed: 25918424 ]
Antitumor substances related to vinblastine and vincristine are exclusively found in the Catharanthus roseus (Madagascar periwinkle), a member of the Apocynaceae plant family, and continue to be extensively used in cancer chemotherapy. Although in high demand, these valuable compounds only accumulate in trace amounts in C. roseus leaves. Vinblastine and vincristine are condensed from the monoterpenoid indole alkaloid (MIA) precursors catharanthine and vindoline. Although catharanthine biosynthesis remains poorly characterized, the biosynthesis of vindoline from the MIA precursor Tabersonine is well understood at the molecular and biochemical levels.
METHODS AND RESULTS:
This study uses virus-induced gene silencing (VIGS) to identify a cytochrome P450 [CYP71D1V2; Tabersonine 3-oxygenase (T3O)] and an alcohol dehydrogenase [ADHL1; Tabersonine 3-reductase (T3R)] as candidate genes involved in the conversion of Tabersonine or 16-methoxyTabersonine to 3-hydroxy-2,3-dihydroTabersonine or 3-hydroxy-16-methoxy-2,3-dihydroTabersonine, which are intermediates in the vindorosine and vindoline pathways, respectively. Biochemical assays with recombinant enzymes confirm that product formation is only possible by the coupled action of T3O and T3R, as the reaction product of T3O is an epoxide that is not used as a substrate by T3R.
CONCLUSIONS:
The T3O and T3R transcripts were identified in a C. roseus database representing genes preferentially expressed in leaf epidermis and suggest that the subsequent reaction products are transported from the leaf epidermis to specialized leaf mesophyll idioblast and laticifer cells to complete the biosynthesis of these MIAs. With these two genes, the complete seven-gene pathway was engineered in yeast to produce vindoline from Tabersonine.
Narcissoside

Catalog No: CFN99773
CAS No: 604-80-8
Price: $70/20mg
Arctiin

Catalog No: CFN99991
CAS No: 20362-31-6
Price: $30/20mg
Eurycomanone

Catalog No: CFN92008
CAS No: 84633-29-4
Price: $268/20mg
Artesunate

Catalog No: CFN90313
CAS No: 88495-63-0
Price: $30/20mg
Myrcene

Catalog No: CFN70046
CAS No: 123-35-3
Price: $30/20mg
Aurantiamide

Catalog No: CFN98984
CAS No: 58115-31-4
Price: $218/5mg
Rebaudioside F

Catalog No: CFN95215
CAS No: 438045-89-7
Price: $268/5mg
Morroniside

Catalog No: CFN98161
CAS No: 25406-64-8
Price: $50/20mg
Catechin

Catalog No: CFN99646
CAS No: 154-23-4
Price: $30/20mg
Cannabidiol

Catalog No: CFN99444
CAS No: 13956-29-1
Price: $40/20mg
Tags: buy Tabersonine | Tabersonine supplier | purchase Tabersonine | Tabersonine cost | Tabersonine manufacturer | order Tabersonine | Tabersonine distributor