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10-Deacetylcephalomannine
10-Deacetylcephalomannine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 10-Deacetylcephalomannine
Price: $318 / 10mg
CAS No.: 76429-85-1
Catalog No.: CFN95519
Molecular Formula: C43H51NO13
Molecular Weight: 789.9 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The barks of Cephalotaxus sinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $273.5 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 10-Deacetylcephalomannin is also active against PS leukemia in vivo, but it is particularly unstable and forms an equilibrium mixture with its cytotoxic C-7 epimer. 10-Deacetylcephalomannine has growth inhibitory activity against human cancer cell lines such as cervical HeLa adenocarcinoma.
10-Deacetylcephalomannine Description
Source: The barks of Cephalotaxus sinensis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.266 mL 6.3299 mL 12.6598 mL 25.3197 mL 31.6496 mL
5 mM 0.2532 mL 1.266 mL 2.532 mL 5.0639 mL 6.3299 mL
10 mM 0.1266 mL 0.633 mL 1.266 mL 2.532 mL 3.165 mL
50 mM 0.0253 mL 0.1266 mL 0.2532 mL 0.5064 mL 0.633 mL
100 mM 0.0127 mL 0.0633 mL 0.1266 mL 0.2532 mL 0.3165 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod . 1981 May-Jun;44(3):312-319.
19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana[Pubmed: 7264680]
Activity-guided, chromatographic fractionation for a polar extract of Taxus wallichiana Zucc. (originally identified as Cephalotaxus mannii Hook.) resulted in the isolation of three new KB cytotoxic taxane derivatives. Nmr and ms spectral analyses permitted their characterization as 19-hydroxybaccatin III (3), 10-Deacetylcephalomannine (4), and 10-deacetyltaxol (5). The latter two compounds, which are also active against PS leukemia in vivo, were observed to be especially labile, each forming equilibrium mixtures with their cytotoxic C-7 epimers (9, 10).
CFN98517Docetaxel114977-28-5807.88C43H53NO14
CFN98516N-Debenzoyl-N-(tert-butoxycarbonyl)taxol125354-16-7849.92C45H55NO15
CFN98518Cephalomannine71610-00-9831.91C45H53NO14
CFN90687Deacetyltaxol78432-77-6811.87C45H49NO13
CFN903717-Epitaxol105454-04-4853.91C47H51NO14
CFN97759Paclitaxel33069-62-4853.92C47H51NO14
CFN985157-Xylosyltaxol90332-66-4986.0C52H59NO18
CFN9083710-Deacetyl-7-xylosyl paclitaxel90332-63-1944.0C50H57NO17
CFN893977-Epi-10-deacetyltaxol78454-17-8811.86C45H49NO13
CFN893957-Epi-10-deacetylcephalomannine78479-12-6789.86C43H51NO13
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