| In vivo: |
| Toxicological & Environmental Chemistry, 1986 , 11 (11) :37-50. | | Acute toxicities of pentachlorophenol, pentachloroanisole, tetrachlorohydroquinone, tetrachlorocatechol, tetrachlororesorcinol, tetrachlorodimethoxybenzenes and tetrachlorobenzenediol diacetates administered to mice[Reference: WebLink] | Pentachlorophenol (PCP), pentachloroanisole (PCAS), tetrachlorohydroquinone (TCH), tetrachlorocatechol (TCC), tetrachlororesorcinol (TCR), Tetrachlorohydroquinone dimethyl ether (TCH‐DME), tetrachlorocatechol dimethyl ether (TCC‐DME), tetrachlororesorcinol dimethyl ether (TCR‐DME), tetrachlorohydroquinone diacetate (TCH‐DA), tetrachlorocatechol diacetate (TCC‐DA), and tetrachlororesorcinol diacetate (TCR‐DA), were investigated for their acute toxicity in male (m) and female (f) mice.
METHODS AND RESULTS:
The substances were administered orally and intraperitoneally, respectively. The oral LD50 values were: 129±9 (m) and 134±9 (f) mg/kg for PCP, 318±22 (m) and 331±22 (f) mg/kg for PCAS, 318±22 (m) and 331±22 (f) mg/kg for TCC, 368±26 (m) and 383±26 (f) mg/kg for TCH, and 736±52 (m) and 767±51 (f) for TCR. The intraperitoneal LD50 values were: 59±4 (m) and 61±4 (f) mg/kg for PCP, 281 ±20 (m) and 293±20 (f) mg/kg for PCAS, 161±11 (m) and 167±11 (f) mg/kg for TCC, 28±2 (m) and 30±2 (f) mg/kg for TCH, and 351±25 (m) and 366±24 (f) mg/kg for TCR.
CONCLUSIONS:
No lethality was found with TCH‐DME, or TCC‐DME, or TCR‐DME, respectively, at oral or intraperitoneal single doses of about 300–400 mg/kg, as well as with TCH‐DA, or TCC‐DA, or TCR‐DA, respectively, at doses nearly 40–50 mg/kg, or 210–250 mg/kg, or 340–420 mg/kg b.wt., respectively (Table I). |
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