Punicalin | CAS:65995-64-4 | Manufacturer ChemFaces

Punicalin

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $66.0 / In-stock
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Description:

Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM).

Targets:

HIV | Immunology & Inflammation related

In vivo:

Am J Chin Med. 1999;27(3-4):371-6.

Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats.[Pubmed: 10592846]

Punicalagin and Punicalin were isolated from the leaves of Terminalia catappa L.
METHODS AND RESULTS:
In this study, we evaluated the anti-inflammatory activity of punicalagin and Punicalin carrageenan-induced hind paw edema in rats. After evaluation of the anti-inflammatory effects, the edema rates were increased by carrageenan administration and reduced by drug treatment. After 4 hr of carrageenan administration, the best effect group was the punicalagin (10 mg/kg) treated group (inhibition rate was 58.15%), and the second was the punicalagin (5 mg/kg)-treated group (inhibition rate was 39.15%). However, even if the anti-inflammatory activity of punicalagin was the same as Punicalin at the 5 mg/kg dose, the inhibition effect from larger doses of punicalagin was increased, but there was a decrease with a larger dose of Punicalin.
CONCLUSIONS:
The data showed that both punicalagin and Punicalin exert anti-inflammatory activity, but treatment with larger doses of Punicalin may induce some cell damages.

J Pharm Pharmacol. 1998 Jul;50(7):789-94.

Antioxidant and hepatoprotective activity of punicalagin and punicalin on carbon tetrachloride-induced liver damage in rats.[Pubmed: 9720629]

Punicalagin and Punicalin, isolated from the leaves of Terminalia catappa L., are used to treat dermatitis and hepatitis. Both compounds have strong antioxidative activity. The antihepatotoxic activity of punicalagin and Punicalin on carbon tetrachloride (CCl4)-induced toxicity in the rat liver was evaluated.
METHODS AND RESULTS:
Levels of serum glutamate-oxalate-transaminase and glutamate-pyruvate-trans-aminase were increased by administration of CCl4 and reduced by drug treatment. Histological changes around the liver central vein and oxidation damage induced by CCl4 also benefited from drug treatment. The results show that both punicalagin and Punicalin have anti-hepatotoxic activity but that the larger dose of Punicalin induced liver damage.
CONCLUSIONS:
Thus even if tannins have strong antioxidant activity at very small doses, treatment with a larger dose will induce cell damage.

Punicalin Description

Source:	The peels of Punica granatum L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Punicalin
Price:	$218 / 20mg
CAS No.:	65995-64-4
Catalog No.:	CFN98113
Molecular Formula:	C₃₄H₂₂O₂₂
Molecular Weight:	782.52 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The peels of Punica granatum L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antioxidants Compound Library Inhibitors Compound Library Hepatoprotective Compound Library Phenols Compound Library Immunology & Inflammation related Inhibitor Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.2779 mL	6.3896 mL	12.7792 mL	25.5585 mL	31.9481 mL
5 mM	0.2556 mL	1.2779 mL	2.5558 mL	5.1117 mL	6.3896 mL
10 mM	0.1278 mL	0.639 mL	1.2779 mL	2.5558 mL	3.1948 mL
50 mM	0.0256 mL	0.1278 mL	0.2556 mL	0.5112 mL	0.639 mL
100 mM	0.0128 mL	0.0639 mL	0.1278 mL	0.2556 mL	0.3195 mL

CFN92805	4,4'-Di-O-methylellagic acid	3374-77-4	330.0	C₁₆H₁₀O₈
CFN92806	3,4'-Di-O-methylellagic acid	57499-59-9	330.0	C₁₆H₁₀O₈
CFN98217	3,8-Di-O-methylellagic acid	2239-88-5	330.3	C₁₆H₁₀O₈
CFN97069	3-O-Methylducheside A	62218-23-9	462.4	C₂₁H₁₈O₁₂
CFN90830	3,3'-Di-O-methylellagic acid 4'-glucoside	51803-68-0	492.4	C₂₂H₂₀O₁₃
CFN99680	2,3,8-Tri-O-methylellagic acid	1617-49-8	344.3	C₁₇H₁₂O₈
CFN99426	3,7-Di-O-methylducheside A	136133-08-9	476.4	C₂₂H₂₀O₁₂
CFN99851	Nyssoside	182138-70-1	490.4	C₂₂H₁₈O₁₃
CFN98113	Punicalin	65995-64-4	782.52	C₃₄H₂₂O₂₂
CFN99938	Punicalagin	65995-63-3	1084.72	C₄₈H₂₈O₃₀