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Punicalin
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Product Name Punicalin
Price: $218 / 20mg
CAS No.: 65995-64-4
Catalog No.: CFN98113
Molecular Formula: C34H22O22
Molecular Weight: 782.52 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The peels of Punica granatum L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
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Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $66.0 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM).
Targets: HIV | Immunology & Inflammation related
In vivo:
Am J Chin Med. 1999;27(3-4):371-6.
Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats.[Pubmed: 10592846]
Punicalagin and Punicalin were isolated from the leaves of Terminalia catappa L.
METHODS AND RESULTS:
In this study, we evaluated the anti-inflammatory activity of punicalagin and Punicalin carrageenan-induced hind paw edema in rats. After evaluation of the anti-inflammatory effects, the edema rates were increased by carrageenan administration and reduced by drug treatment. After 4 hr of carrageenan administration, the best effect group was the punicalagin (10 mg/kg) treated group (inhibition rate was 58.15%), and the second was the punicalagin (5 mg/kg)-treated group (inhibition rate was 39.15%). However, even if the anti-inflammatory activity of punicalagin was the same as Punicalin at the 5 mg/kg dose, the inhibition effect from larger doses of punicalagin was increased, but there was a decrease with a larger dose of Punicalin.
CONCLUSIONS:
The data showed that both punicalagin and Punicalin exert anti-inflammatory activity, but treatment with larger doses of Punicalin may induce some cell damages.
J Pharm Pharmacol. 1998 Jul;50(7):789-94.
Antioxidant and hepatoprotective activity of punicalagin and punicalin on carbon tetrachloride-induced liver damage in rats.[Pubmed: 9720629]
Punicalagin and Punicalin, isolated from the leaves of Terminalia catappa L., are used to treat dermatitis and hepatitis. Both compounds have strong antioxidative activity. The antihepatotoxic activity of punicalagin and Punicalin on carbon tetrachloride (CCl4)-induced toxicity in the rat liver was evaluated.
METHODS AND RESULTS:
Levels of serum glutamate-oxalate-transaminase and glutamate-pyruvate-trans-aminase were increased by administration of CCl4 and reduced by drug treatment. Histological changes around the liver central vein and oxidation damage induced by CCl4 also benefited from drug treatment. The results show that both punicalagin and Punicalin have anti-hepatotoxic activity but that the larger dose of Punicalin induced liver damage.
CONCLUSIONS:
Thus even if tannins have strong antioxidant activity at very small doses, treatment with a larger dose will induce cell damage.
Punicalin Description
Source: The peels of Punica granatum L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2779 mL 6.3896 mL 12.7792 mL 25.5585 mL 31.9481 mL
5 mM 0.2556 mL 1.2779 mL 2.5558 mL 5.1117 mL 6.3896 mL
10 mM 0.1278 mL 0.639 mL 1.2779 mL 2.5558 mL 3.1948 mL
50 mM 0.0256 mL 0.1278 mL 0.2556 mL 0.5112 mL 0.639 mL
100 mM 0.0128 mL 0.0639 mL 0.1278 mL 0.2556 mL 0.3195 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Phytother Res. 2004 Aug;18(8):667-9.
Two ellagitannins from the leaves of Terminalia triflora with inhibitory activity on HIV-1 reverse transcriptase.[Pubmed: 15472920]
The bioassay- guided fractionation of the aqueous extract of Terminalia triflora leaves afforded Punicalin and 2-O-galloylPunicalin, isolated for the first time from this species.
METHODS AND RESULTS:
These compounds showed inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner. Punicalin showed an IC(50) of 0.11 microg/ml (0.14 microM) and 2-O-galloylPunicalin an IC(50) of 0.10 microg/ml (0.11 microM).
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