Tirucallol | CAS:514-46-5 | Manufacturer ChemFaces

Tirucallol

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Description:

Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.

Targets:

PGE | NO | NOS | TNF-α | NF-kB | p65

In vitro:

Exp Biol Med (Maywood). 2009 May;234(5):553-61.

Chios mastic gum extract and isolated phytosterol tirucallol exhibit anti-inflammatory activity in human aortic endothelial cells.[Pubmed: 19234052 ]

Chios mastic gum (CMG) is a white, semitransparent, natural resin that is obtained as a trunk exudate from mastic trees. Triterpenic compounds and phytosterols like Tirucallol are among its major components. CMG has been associated with cardiovascular protection, exerting its effect mainly through increasing the antioxidant defense system, and effectively lowering the levels of serum cholesterol in human subjects. However, data on its anti-inflammatory effect on endothelium are scarce. Attachment of leukocytes to the vascular endothelium and the subsequent migration of cells into the vessel wall are early events in atherogenesis, and this process requires the expression of endothelial adhesion molecules.
METHODS AND RESULTS:
In this study, we examined the effect of CMG neutral extract (25-200 microg/ml) and Tirucallol (0.1-100 microM) on the following: 1) the expression of adhesion molecules (VCAM-1 and ICAM-1) by Cell ELISA and 2) the attachment of monocytes (U937 cells) in TNF-alpha stimulated Human Aortic Endothelial Cells (HAEC) by Adhesion assay. The impact of treatment with CMG neutral extract and Tirucallol in NFkB phosphorylation was also examined by a cell-based ELISA kit. Both CMG extract and Tirucallol inhibit significantly VCAM-1 and ICAM-1 expression in TNF-alpha-stimulated HAEC. They also inhibit significantly the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuate the phosphorylation of NFkB p65.
CONCLUSIONS:
This study extends existing data regarding the cardioprotective effect of CMG, expands the spectrum of known phytosterols with potent antiatheromatic activity, provides new insight into the mechanisms underlying the beneficial effect of CMG on endothelial function, and may aid in design of new therapy for intervention in atherosclerosis.

Tirucallol Description

Source:	The roots of Euphorbia ebracteolata Hayata.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Phytomedicine. 2010 Feb;17(2):146-8.

Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex.[Pubmed: 19577446 ]

Latex from Euphorbia lactea (Euphorbiaceae), a native Dominican medicinal plant, is claimed to be useful in the treatment of inflammation.
METHODS AND RESULTS:
Topical application of Tirucallol, a tetracyclic triterpene isolated from Euphorbia lacteal latex, suppressed ear edema in the mouse model in a dose-dependent manner, as well as affecting the influx of polymorphonuclear cells in response to topical application of 12-O-tetradecanoylphorbol-acetate (TPA) in the mouse ear. In addition, the effect of Tirucallol, on some macrophage functions was analyzed in vitro. Non-toxic concentrations of Tirucallol potently inhibited nitrite production in lipopolysaccharide-stimulated macrophages. Western blot analysis showed that nitric oxide reduction was a consequence of the inhibition of inducible nitric oxide synthetase expression although Tirucallol slightly affected to prostaglandin E(2) (PGE(2)) generation.
CONCLUSIONS:
The results of the study revealed that Tirucallol (0.3%), present in Euphorbia lactea latex, exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration. On the other hand, it can be deduced that the mechanism of the anti-inflammatory activity of this triterpene is related to the control of the production of NO and its effect on the expression of iNOS.

Structure Identification:

J Asian Nat Prod Res. 2000;2(4):257-61.

An isopimarane diterpene from Euphorbia ebracteolata Hayata.[Pubmed: 11249607 ]

CONCLUSIONS:
From the ethanolic extract of the roots of Euphorbia ebracteolata Hayata four compounds were isolated. They are 24-methylenecycloartanone, Tirucallol, procesterol and a new isopimarane diterpene, namely yuexiandajisu C.
CONCLUSIONS:
The structure of yuexiandajisu C was elucidated by spectral analysis. The bioassay in vitro showed yuexiandajisu C exhibited immunomodulatory activity.

Product Name	Tirucallol
Price:	$218 / 5mg
CAS No.:	514-46-5
Catalog No.:	CFN89512
Molecular Formula:	C₃₀H₅₀O
Molecular Weight:	426.71 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Euphorbia ebracteolata Hayata.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Triterpenoids Compound Library TNF-α Inhibitor Library PGE Inhibitor Library p65 Inhibitor Library NOS Inhibitor Library NO Inhibitor Library NF-kB Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3435 mL	11.7176 mL	23.4351 mL	46.8702 mL	58.5878 mL
5 mM	0.4687 mL	2.3435 mL	4.687 mL	9.374 mL	11.7176 mL
10 mM	0.2344 mL	1.1718 mL	2.3435 mL	4.687 mL	5.8588 mL
50 mM	0.0469 mL	0.2344 mL	0.4687 mL	0.9374 mL	1.1718 mL
100 mM	0.0234 mL	0.1172 mL	0.2344 mL	0.4687 mL	0.5859 mL

CFN92376	Butyrospermol	472-28-6	426.7	C₃₀H₅₀O
CFN92977	Kulinone	21688-61-9	440.70	C₃₀H₄₈O₂
CFN96579	Aphagranin A	1318173-53-3	546.79	C₃₃H₅₄O₆
CFN91924	Pseudolarifuroic acid	130825-79-5	466.65	C₃₀H₄₂O₄
CFN97609	3-Oxotirucalla-7,24-dien-21-oic acid	82464-35-5	454.69	C₃₀H₄₆O₃
CFN92975	Methyl kulonate	22611-37-6	484.71	C₃₁H₄₈O₄
CFN92825	Parkeol	514-45-4	426.7	C₃₀H₅₀O
CFN92378	Cucurbitadienol	35012-08-9	426.7	C₃₀H₅₀O
CFN92367	Inotodiol	35963-37-2	442.7	C₃₀H₅₀O₂
CFN92365	3beta-Hydroxylanosta-8,24-diene-21-al	96574-03-7	440.7	C₃₀H₄₈O₂