Neogambogic acid | CAS:93772-31-7 | Manufacturer ChemFaces

Neogambogic acid

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Size /Price /Stock	10 mM * 1 mL in DMSO / $101.7 / In-stock
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Description:

Neogambogic acid , an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell line MCF-7 cells.

Targets:

Bcl-2/Bax | Caspase | P450 (e.g. CYP17)

In vitro:

Acta Biochim Biophys Sin (Shanghai). 2011 Sep;43(9):698-702.

The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells.[Pubmed: 21785112]

Neogambogic acid (NGA), an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect. We hypothesize that NGA may be responsible for the inhibition of proliferation of human breast cancer cell line MCF-7 cells.
METHODS AND RESULTS:
To investigate its anticancer mechanism in vitro, MCF-7 cells were treated with various concentrations of NGA. Results of MTT (methyl thiazolyl tetrazolum) assay showed that treatment with NGA significantly reduced the proliferation of MCF-7 cells in a dose-dependent manner. NGA could increase the expression of the apoptosis-related proteins FasL, caspase-3, caspase-8, caspase-9, and Bax and decrease the expression of anti-apoptotic protein Bcl-2 accompanied by the mitochondrial transmembrane damage. The antiproliferative effect of NGA on MCF-7 cells is due to the G(0)/G(1) arrest, increased apoptosis and activation of Fas/FasL and cytochrome C pathway.
CONCLUSIONS:
These results provide an important insight into the cellular and molecular mechanisms through which NGA impairs the proliferation of breast cancer cells.

Neogambogic acid Description

Source:	The herbs of Garcinia hanburyi Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Neogambogic acid
Price:	$258 / 20mg
CAS No.:	93772-31-7
Catalog No.:	CFN90175
Molecular Formula:	C₃₈H₄₆O₉
Molecular Weight:	646.77 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Yellow cryst.
Source:	The herbs of Garcinia hanburyi Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Miscellaneous Compound Library P450 (e.g. CYP17) Inhibitor Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5461 mL	7.7307 mL	15.4614 mL	30.9229 mL	38.6536 mL
5 mM	0.3092 mL	1.5461 mL	3.0923 mL	6.1846 mL	7.7307 mL
10 mM	0.1546 mL	0.7731 mL	1.5461 mL	3.0923 mL	3.8654 mL
50 mM	0.0309 mL	0.1546 mL	0.3092 mL	0.6185 mL	0.7731 mL
100 mM	0.0155 mL	0.0773 mL	0.1546 mL	0.3092 mL	0.3865 mL

CFN92957	Gambogoic acid B	887923-50-4	674.82	C₄₀H₅₀O₉
CFN95458	Gambogic acid A	1592842-93-7	676.8	C₃₉H₄₈O₁₀
CFN93214	Gambogellic acid	173867-04-4	628.76	C₃₈H₄₄O₈
CFN95438	Epigambogellic acid	1352191-85-5	628.8	C₃₈H₄₄O₈
CFN92086	Isogambogenin	173938-23-3	614.8	C₃₈H₄₆O₇
CFN92088	Desoxygambogenin	173614-93-2	600.8	C₃₈H₄₈O₆
CFN92096	Isogambogenic acid	887923-47-9	630.8	C₃₈H₄₆O₈
CFN92097	Gambogenic acid	173932-75-7	630.8	C₃₈H₄₆O₈
CFN95450	10-Methoxygambogenic acid	2095102-72-8	662.8	C₃₉H₅₀O₉
CFN90172	Gambogic acid	2752-65-0	628.75	C₃₈H₄₄O₈