Trimethoxystilbene | CAS:22255-22-7 | Manufacturer ChemFaces

Trimethoxystilbene

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Size /Price /Stock	10 mM * 1 mL in DMSO / $8.9 / In-stock
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Description:

Trimethoxystilbene has anti-cancer activity, it inhibits cancer cell growth by inducing multipolar cell mitosis.

In vitro:

Mol Carcinog. 2017 Mar;56(3):1117-26.

The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis.[Pubmed: 27739192 ]

Natural compounds are extensively studied for their potential use in traditional and non-traditional medicine. Several natural and synthetic Resveratrol analogues have shown interesting biological activities in the field of cancer chemoprevention.
METHODS AND RESULTS:
In the present study, we have focused on the ability of Resveratrol and two methoxylated derivatives (Trimethoxystilbene and Pterostilbene) to inhibit human cancer cell growth particularly analyzing their ability to interfere with tubulin dynamics at mitosis. We show that Trimethoxystilbene, differently from Resveratrol and Pterostilbene, alters microtubule polymerization dynamics in HeLa cells specifically inducing multipolar spindles and mitotic arrest coupled to a reduction of cell growth and an increase in apoptotic death by mitotic catastrophe.
CONCLUSIONS:
This work demonstrates that the structural modification of Rsv causes substantial changes in the mechanism of action of the derivatives. The presence of three extra methyl groups renders Trimethoxy very efficient in impairing cell proliferation by inducing mitotic catastrophe in cancer cells.

Trimethoxystilbene Description

Source:	The herbs of Sophora viciifolia.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Trimethoxystilbene
Price:	$40 / 20mg
CAS No.:	22255-22-7
Catalog No.:	CFN90874
Molecular Formula:	C₁₇H₁₈O₃
Molecular Weight:	270.3 g/mol
Purity:	>=98%
Type of Compound:	Polyphenols
Physical Desc.:	Powder
Source:	The herbs of Sophora viciifolia.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6996 mL	18.498 mL	36.9959 mL	73.9919 mL	92.4898 mL
5 mM	0.7399 mL	3.6996 mL	7.3992 mL	14.7984 mL	18.498 mL
10 mM	0.37 mL	1.8498 mL	3.6996 mL	7.3992 mL	9.249 mL
50 mM	0.074 mL	0.37 mL	0.7399 mL	1.4798 mL	1.8498 mL
100 mM	0.037 mL	0.185 mL	0.37 mL	0.7399 mL	0.9249 mL

CFN95783	Resveratrol 12-C-beta-glucopyranoside	163527-00-2	390.4	C₂₀H₂₂O₈
CFN99021	Dihydroresveratrol 3-O-glucoside	100432-87-9	392.4	C₂₀H₂₄O₈
CFN90854	Desoxyrhapontigenin	33626-08-3	242.3	C₁₅H₁₄O₃
CFN90911	Desoxyrhaponticin	30197-14-9	404.4	C₂₁H₂₄O₈
CFN91099	Rhaponticin 6''-O-gallate	94356-23-7	572.51	C₂₈H₂₈O₁₃
CFN91100	Rhaponticin 2''-O-gallate	94356-24-8	572.51	C₂₈H₂₈O₁₃
CFN99995	2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside	82373-94-2	406.39	C₂₀H₂₂O₉
CFN98662	Pinostilbene	42438-89-1	242.3	C₁₅H₁₄O₃
CFN95285	1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane	1338076-61-1	566.6	C₂₈H₃₈O₁₂
CFN98995	Pinostilbenoside	58762-96-2	404.4	C₂₁H₂₄O₈