Triptonine B | CAS:168009-85-6 | Manufacturer ChemFaces

Triptonine B

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Description:

Triptonine B demonstrates potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.

Targets:

HIV

In vitro:

J Nat Prod. 2000 Mar;63(3):357-61.

Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: a new class of potent anti-HIV agents.[Pubmed: 10757718]

Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wilfordinines A (3), B (4), and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygium hypoglaucum and a clinically used extract of Tripterygium wilfordii.
METHODS AND RESULTS:
The structures of 1-5 were elucidated by spectroscopic methods. The anti-HIV activity of 1, 2, and several related compounds was evaluated. Triptonine B (2) demonstrated potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.

Triptonine B Description

Source:	The roots of Tripterygium wilfordii Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Triptonine B
Price:	$468 / 5mg
CAS No.:	168009-85-6
Catalog No.:	CFN92116
Molecular Formula:	C₄₆H₄₉NO₂₂
Molecular Weight:	967.9 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The roots of Tripterygium wilfordii Hook. f.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antiviral Compound Library Sesquiterpenoids Compound Library HIV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0332 mL	5.1658 mL	10.3316 mL	20.6633 mL	25.8291 mL
5 mM	0.2066 mL	1.0332 mL	2.0663 mL	4.1327 mL	5.1658 mL
10 mM	0.1033 mL	0.5166 mL	1.0332 mL	2.0663 mL	2.5829 mL
50 mM	0.0207 mL	0.1033 mL	0.2066 mL	0.4133 mL	0.5166 mL
100 mM	0.0103 mL	0.0517 mL	0.1033 mL	0.2066 mL	0.2583 mL

CFN92115	Regelidine	114542-54-0	599.7	C₃₅H₃₇NO₈
CFN92102	Evonimine	41758-69-4	805.8	C₃₈H₄₇NO₁₈
CFN92117	Aquifoliunine E-III	220751-20-2	763.8	C₃₆H₄₅NO₁₇
CFN92107	Evonine	33458-82-1	805.8	C₃₈H₄₇NO₁₈
CFN92106	Hypoglaunine A	228259-16-3	873.8	C₄₁H₄₇NO₂₀
CFN92105	Wilfortrine	37239-48-8	873.8	C₄₁H₄₇NO₂₀
CFN98605	Wilforgine	37239-47-7	857.8	C₄₁H₄₇NO₁₉
CFN92116	Triptonine B	168009-85-6	967.9	C₄₆H₄₉NO₂₂