Clerosterol | CAS:2364-23-0 | Manufacturer ChemFaces

Clerosterol

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Description:

Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone in biosynthesis of phytoecdysteroids of Ajuga hairy roots. Clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis.

Targets:

Bcl-2/Bax | Caspase

In vitro:

Marine Drugs, 2013, 11(2):418-30.

Cytotoxic Effect of Clerosterol Isolated from Codium fragile on A2058 Human Melanoma Cells[Pubmed: PMC3640389]

The cytotoxic effects and mechanism of action of Clerosterol, isolated from the marine alga Codium fragile, were investigated in A2058 human melanoma cells.
METHODS AND RESULTS:
Clerosterol inhibited the growth of A2058 cells with an IC(50) of 150 µM and induced apoptotic cell death, as evidenced by DNA fragmentation, an increase in the number of sub-G(1) hypodiploid cells and the presence of apoptotic bodies. Clerosterol treatment caused the loss of mitochondrial membrane potential. Alterations in the expression of apoptosis-associated proteins in response to Clerosterol treatment included upregulation of Bax, downregulation of Bcl-2 and activation of caspases 3 and 9. The pan-caspase inhibitor treatment attenuated the expression of the active form of caspases and cell death induced by Clerosterol.
CONCLUSIONS:
The present results show that Clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis.

Clerosterol Description

Source:	The herbs of Cleredendrum cwtophyllum Turcz.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Clerosterol
Price:
CAS No.:	2364-23-0
Catalog No.:	CFN90787
Molecular Formula:	C₂₉H₄₈O
Molecular Weight:	412.7 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Cleredendrum cwtophyllum Turcz.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-melanogenic Compound Library Precursors Compound Library Steroids Compound Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4231 mL	12.1153 mL	24.2307 mL	48.4614 mL	60.5767 mL
5 mM	0.4846 mL	2.4231 mL	4.8461 mL	9.6923 mL	12.1153 mL
10 mM	0.2423 mL	1.2115 mL	2.4231 mL	4.8461 mL	6.0577 mL
50 mM	0.0485 mL	0.2423 mL	0.4846 mL	0.9692 mL	1.2115 mL
100 mM	0.0242 mL	0.1212 mL	0.2423 mL	0.4846 mL	0.6058 mL

CFN92239	Delta 5-avenasterol	18472-36-1	412.7	C₂₉H₄₈O
CFN92240	Delta 7-avenasterol	23290-26-8	412.7	C₂₉H₄₈O
CFN90787	Clerosterol	2364-23-0	412.7	C₂₉H₄₈O
CFN98304	22-Dehydroclerosterol	26315-07-1	410.7	C₂₉H₄₆O
CFN98350	22-Dehydroclerosteryl acetate	28594-00-5	452.7	C₃₁H₄₈O₂
CFN99498	3beta-Hydroxyporiferast-5-en-7-one	145163-97-9	428.7	C₂₉H₄₈O₂
CFN89063	Citrostadienol	474-40-8	426.72	C₃₀H₅₀O