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Tussilagine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Tussilagine
Price:
CAS No.: 80151-77-5
Catalog No.: CFN00272
Molecular Formula: C10H17NO3
Molecular Weight: 199.25 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Echinacea purpurea.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
In vitro:
Planta Medica, 1998, 64(03):259-263.
Generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine.[Reference: WebLink]
Monoclonal antibodies against retrorsine were established using a retrorsine-hemisuccinate::bovine-thyroglobuline conjugate as antigen for immunization.
METHODS AND RESULTS:
In competitive enzyme-linked immunoassays the specificity of the obtained antibodies was tested with 20 different pyrrolizidine alkaloids. Among these the alkaloids acetylgynuramine, gynuramine, integerrimine, neoplatyphylline, platyphylline, rosmarinine, senecionine, and seneciphylline were able to bind the antibody. There was no cross-reactivity with the alkaloids senkirkine, angeloylheliotridine, heliotridine, axillarine, anacrotine, monocrotaline, madurensine, otosenine, retronecine, Tussilagine, triangularine, and jacoline as well as with seneciphylline N-oxide.
CONCLUSIONS:
From this antigen spectrum it can be concluded that besides the necic structure itself the dominant and discriminative epitope consists of the exocyclic ethylidene group of the various diesters.
Tussilagine Description
Source: The herbs of Echinacea purpurea.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.0188 mL 25.0941 mL 50.1882 mL 100.3764 mL 125.4705 mL
5 mM 1.0038 mL 5.0188 mL 10.0376 mL 20.0753 mL 25.0941 mL
10 mM 0.5019 mL 2.5094 mL 5.0188 mL 10.0376 mL 12.5471 mL
50 mM 0.1004 mL 0.5019 mL 1.0038 mL 2.0075 mL 2.5094 mL
100 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.0038 mL 1.2547 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry, 1992, 31(12):4135-4137.
Co-occurrence of 2-pyrrolidineacetic acid with the pyrrolizidines tussilaginic acid and isotussilaginic acid and their 1-epimers in Arnica species and Tussilago farfara.[Reference: WebLink]

METHODS AND RESULTS:
Flowerheads of Arnica montana, A. chamissonis ssp. foliosa, A. amplexicaulis and A. sachalinensis contained, in addition to the pyrrolizidine alkaloids, tussilaginic acid and isotussilaginic acid, 2-pyrrolidineacetic acid and the C-1 epimers of the two pyrrolizidine acids. Biosynthetic aspects are discussed on the basis of this co-occurrence.
CONCLUSIONS:
The pyrrolizidines Tussilagine and isoTussilagine, formerly reported for Asteraceae species, are artefacts caused by Soxhlet extraction with methanol.
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