VE-821 | CAS:1232410-49-9 | Manufacturer ChemFaces

VE-821

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Ganoderiol F

Catalog No: CFN99244
CAS No: 114567-47-4
Price: $398/5mg

Pinostrobin

Catalog No: CFN98739
CAS No: 480-37-5
Price: $218/20mg

Danshensu

Catalog No: CFN99539
CAS No: 22681-72-7
Price: $70/20mg

Catalpol

Catalog No: CFN98251
CAS No: 2415-24-9
Price: $40/20mg

Salvianolic acid A

Catalog No: CFN99161
CAS No: 96574-01-5
Price: $128/20mg

Sesamolin

Catalog No: CFN99799
CAS No: 526-07-8
Price: $168/20mg

Curculigoside

Catalog No: CFN97419
CAS No: 85643-19-2
Price: $70/20mg

Pterostilbene

Catalog No: CFN90397
CAS No: 537-42-8
Price: $40/20mg

4-Hydroxybenzyl alcohol

Catalog No: CFN97071
CAS No: 623-05-2
Price: $30/20mg

Hydrangenol

Catalog No: CFN98745
CAS No: 480-47-7
Price: $ /

VE-821 Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

J Med Chem,2011 Apr 14;54(7):2320-30.

Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.[Pubmed: 21490603]

The ability of compounds to inhibit ATR, ATM or DNAPK kinase activity istested using a radiometric-phosphate incorporation assay. A stock solution isprepared consisting of the appropriate buffer, kinase, and target peptide. To this isadded the compound of interest, at varying concentrations in DMSO to a final DMSO concentration of 7%. Assays are initiated by addition of an appropriate [γ-33P]ATP solution and incubated at 25 ℃. Assays are stopped, after the desired time course, by addition of phosphoric acid and ATP to a final concentration of 100 mM and 0.66μM, respectively. Peptides are captured on a phosphocellulose membrane, prepared as per manufacturer

Cell Research:

J Med Chem,2011 Apr 14;54(7):2320-30.

Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.[Pubmed: 21413798]

Cell lines:H2AX cells
Concentrations: ———
Incubation Time: -96 hours
Method:
Cells are plated in 96-well plates and allowed to adhere overnight. The following day, compounds are added at the indicated concentrations in a final volume of 200μL, and the cells are then incubated for 96 h. MTS reagent (40μL) isthen added, and 1 h later, absorbance at 490 nm ismeasured using a SpectraMax Plus 384 plate reader. Synergy and antagonism are assessed using Macsynergy software.

Product Name	VE-821
Price:
CAS No.:	1232410-49-9
Catalog No.:	CFN60006
Molecular Formula:	C₁₈H₁₆N₄O₃S
Molecular Weight:	368.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library PI3K Inhibitor Library mTOR Inhibitor Library DNA-PK Inhibitor Library

Description:	VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.
Targets:	ATP \| H2AX \| mTOR \| PI3K \| DNA-PK \| PIKKs

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7144 mL	13.5722 mL	27.1444 mL	54.2888 mL	67.861 mL
5 mM	0.5429 mL	2.7144 mL	5.4289 mL	10.8578 mL	13.5722 mL
10 mM	0.2714 mL	1.3572 mL	2.7144 mL	5.4289 mL	6.7861 mL
50 mM	0.0543 mL	0.2714 mL	0.5429 mL	1.0858 mL	1.3572 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.5429 mL	0.6786 mL

CFN90934	Escin IB	26339-90-2	1131.3	C₅₅H₈₆O₂₄
CFN98016	Xanthotoxol	2009-24-7	202.2	C₁₁H₆O₄
CFN89550	Delgrandine	145237-05-4	741.77	C₄₁H₄₃NO₁₂
CFN93206	Clemastanin A	172670-47-2	508.52	C₂₅H₃₂O₁₁