Vasicine | CAS:6159-55-3 | Manufacturer ChemFaces

Vasicine

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Description:

Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's disease. Vasicine can regulate the inflammatory reaction, have great potentials to develop safe medications for respiratory and reproductive medicine.Vasicine is also oxytocic and abortifacient agents.

Targets:

Antifection | AChR

In vitro:

Pak J Pharm Sci. 2012 Jul;25(3):651-6.

Enzyme inhibition, antioxidant and antibacterial potential of vasicine isolated from Adhatoda vasica Nees.[Pubmed: 22713956 ]

Vasicine (1) was isolated from the ethanolic extract of Adhatoda vasica Nees (Acanthaceae) and the structure was confirmed using spectroscopic techniques.
METHODS AND RESULTS:
Acetylcholine esterase, trypsin, DPPH inhibition potential and FRAP assay were carried out using in vitro models. The results showed 38.4 ± 1.2% and 37.4 ± 1.1% activity in acetylcholine and trypsin inhibition assays respectively. The compound (1) exhibited significant DPPH inhibition activity (70.4 ± 1.3%, IC(50) = 212.3 ± 1.9 μM). A dose dependant behavior of Vasicine (1), was indicated in the FRAP assay.
CONCLUSIONS:
Antibacterial activity was checked according to agar well diffusion assay and results revealed that Vasicine (1) showed moderate activity.

Vasicine Description

Source:	The leaves of Adhatoda vasica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

PLoS One. 2015 Apr 7;10(4):e0122366.

In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor.[Pubmed: 25849329]

Vasicine (VAS), a potential natural cholinesterase inhibitor, exhibited promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer's disease.
METHODS AND RESULTS:
This study systematically investigated the in vitro and in vivo metabolism of Vasicine in rat using ultra performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry. Results indicated that renal clearance was the major excretion pathway of Vasicine. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of Vasicine and its main metabolites were also evaluated.
CONCLUSIONS:
The results indicated that although most metabolites maintained potential inhibitory activity against AChE and BChE, but weaker than that of Vasicine. Vasicine undergoes metabolic inactivation process in vivo in respect to cholinesterase inhibitory activity.

Product Name	Vasicine
Price:	$218 / 10mg
CAS No.:	6159-55-3
Catalog No.:	CFN97052
Molecular Formula:	C₁₁H₁₂N₂O
Molecular Weight:	188.2 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The leaves of Adhatoda vasica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antioxidants Compound Library Antibacterial Compound Library Anticholinesterase Compound Library Alkaloids Compound Library Antifection Inhibitor Library AChR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.3135 mL	26.5675 mL	53.135 mL	106.2699 mL	132.8374 mL
5 mM	1.0627 mL	5.3135 mL	10.627 mL	21.254 mL	26.5675 mL
10 mM	0.5313 mL	2.6567 mL	5.3135 mL	10.627 mL	13.2837 mL
50 mM	0.1063 mL	0.5313 mL	1.0627 mL	2.1254 mL	2.6567 mL
100 mM	0.0531 mL	0.2657 mL	0.5313 mL	1.0627 mL	1.3284 mL

CFN98773	Vasicinone	486-64-6	202.2	C₁₁H₁₀N₂O₂
CFN97406	Vasicinolone	84847-50-7	218.2	C₁₁H₁₀N₂O₃
CFN98889	Coixol	532-91-2	165.1	C₈H₇NO₃
CFN97184	2,7-Dihydroxy-2H-1,4-benzoxazin-3(4H)-one	69804-59-7	181.1	C₈H₇NO₄
CFN89192	Arborine	6873-15-0	250.30	C₁₆H₁₄N₂O
CFN92302	Febrifugine	24159-07-7	301.3	C₁₆H₁₉N₃O₃
CFN92303	Isofebrifugine	32434-44-9	301.3	C₁₆H₁₉N₃O₃
CFN91939	Desoxypeganine	495-59-0	172.23	C₁₁H₁₂N₂
CFN97052	Vasicine	6159-55-3	188.2	C₁₁H₁₂N₂O
CFN99009	Vasicinol	5081-51-6	204.2	C₁₁H₁₂N₂O₂