Vasicinol | CAS:5081-51-6 | Manufacturer ChemFaces

Vasicinol

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Vasicinol Description

Source:	The leaves of Adhatoda vasica Nees
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Food Chem. 2008 Jun 1;108(3):965-72.

Inhibitory effect on α-glucosidase by Adhatoda vasica Nees.[Pubmed: 26065759]

Methanolic extracts from the medicinal parts of 40 traditional Chinese herbs were tested in screening experiments for rat intestinal α-glucosidase.
METHODS AND RESULTS:
The methanolic extract from the leaves of Adhatoda vasica Nees (Acanthaceae) showed the highest sucrase inhibitory activity with sucrose as a substrate. Enzyme assay-guided fractionation of this extract afforded vasicine (1) and Vasicinol (2), and the structures of these compounds were elucidated on the basis of MS and NMR analysis. Compounds 1 and 2 showed a high sucrase inhibitory activity, and the IC50 values were 125μM and 250μM, respectively. Both 1 and 2 were shown to be reversible inhibitors of sucrase. Kinetic data revealed that compounds 1 and 2 inhibited sucrose-hydrolysing activity of rat intestinal α-glucosidase competitively with Ki values of 82μM and 183μM, respectively. This is the first report on the mammalian α-glucosidase inhibition of A. vasica and the inhibitory effect on sucrase by 1 and 2 from this herb species.
CONCLUSIONS:
These results suggest a use of the extract of A. vasica as an antidiabetic agent and show a possibility that compounds 1 and 2 could be an useful treatment for metabolic disorders.

Structure Identification:

Tetrahedron: Asymmetry, 1996,7(1):25–28.

Reversal of absolute stereochemistry of the pyrrolo[2,1-b]quinazoline alkaloids vasicine, vasicinone, vasicinol and vasicinolone[Reference: WebLink]

METHODS AND RESULTS:
The previously assigned 3R configuration of (−)-vasicinone has been reversed and this pyrrolo[2,1-b]quinazoline-9-one has been shown to have the 3S-configuration (3) on the basis of an X-ray diffraction study of (+)-vasicinone hydrobromide. Likewise, the 3R stereochemistry assigned earlier to (−)-vasicine (peganine) (1) on the basis of an X-ray analysis of its hydrochloride has also been reversed by reinvestigation of the X-ray diffraction analysis of the hydrobromide. The absolute stereochemistry of the alkaloids (+)-Vasicinol (2) and Vasicinolone (5) which have been inter-related, should also have the 3S-configuration.
CONCLUSIONS:
A study of the 1H nmr spectroscopy of (−)-vasicine by the use of Mosher's method using MTPA [α-methoxy-α-(trifluoromethyl)phenylacetic acid] esters indicated an exception to this model for establishing the absolute configuration.

Product Name	Vasicinol
Price:
CAS No.:	5081-51-6
Catalog No.:	CFN99009
Molecular Formula:	C₁₁H₁₂N₂O₂
Molecular Weight:	204.2 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The leaves of Adhatoda vasica Nees
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antifertility Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.8972 mL	24.4858 mL	48.9716 mL	97.9432 mL	122.429 mL
5 mM	0.9794 mL	4.8972 mL	9.7943 mL	19.5886 mL	24.4858 mL
10 mM	0.4897 mL	2.4486 mL	4.8972 mL	9.7943 mL	12.2429 mL
50 mM	0.0979 mL	0.4897 mL	0.9794 mL	1.9589 mL	2.4486 mL
100 mM	0.049 mL	0.2449 mL	0.4897 mL	0.9794 mL	1.2243 mL

CFN98889	Coixol	532-91-2	165.1	C₈H₇NO₃
CFN97184	2,7-Dihydroxy-2H-1,4-benzoxazin-3(4H)-one	69804-59-7	181.1	C₈H₇NO₄
CFN89192	Arborine	6873-15-0	250.30	C₁₆H₁₄N₂O
CFN92302	Febrifugine	24159-07-7	301.3	C₁₆H₁₉N₃O₃
CFN92303	Isofebrifugine	32434-44-9	301.3	C₁₆H₁₉N₃O₃
CFN91939	Desoxypeganine	495-59-0	172.23	C₁₁H₁₂N₂
CFN97052	Vasicine	6159-55-3	188.2	C₁₁H₁₂N₂O
CFN99009	Vasicinol	5081-51-6	204.2	C₁₁H₁₂N₂O₂
CFN98882	Deoxyvasicinone	530-53-0	186.2	C₁₁H₁₀N₂O
CFN98773	Vasicinone	486-64-6	202.2	C₁₁H₁₀N₂O₂