Worenine | CAS:38763-29-0 | Manufacturer ChemFaces

Worenine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Reference standards.

In vivo:

J Pharm Biomed Anal. 2010 Jan 5;51(1):236-43.

Characterization of metabolites of worenine in rat biological samples using liquid chromatography-tandem mass spectrometry.[Pubmed: 19773142]

The in vivo and in vitro metabolites of Worenine in rat were identified or characterized using a specific and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method.
METHODS AND RESULTS:
In vivo samples including rat urine, feces, and plasma samples were collected after ingestion of 25 mg/kg Worenine to healthy rats. The in vivo and in vitro samples were cleaned up by a solid-phase extraction procedure (C18 cartridges) and a liquid-liquid extraction procedure, respectively. Then these pretreated samples were injected into a reversed-phase C18 column with mobile phase of methanol-ammonium acetate (2mM, adjusted to pH 3.5 with formic acid) (60:40, v/v) and detected by an on-line MS/MS system. As a result, at least twenty-seven metabolites and the parent medicine were found in rat urine after ingestion of Worenine. Seven metabolites and the parent medicine were identified or characterized in rat feces. Three metabolites and the parent medicine were detected in rat plasma. One metabolite was found in the rat intestinal flora incubation mixture, and three metabolites were characterized in the homogenized liver incubation mixture.
CONCLUSIONS:
The main phase I metabolism of Worenine in rat was dehydrogenization, hydrogenation, hydroxylation, and demethylene reactions, and that of phase II was sulfation and glucuronidation.

Worenine Description

Source:	The roots of Coptis chinensis Franch.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Worenine
Price:
CAS No.:	38763-29-0
Catalog No.:	CFN90415
Molecular Formula:	C₂₀H₁₆NO₄+
Molecular Weight:	334.11 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The roots of Coptis chinensis Franch.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.993 mL	14.9651 mL	29.9303 mL	59.8605 mL	74.8257 mL
5 mM	0.5986 mL	2.993 mL	5.9861 mL	11.9721 mL	14.9651 mL
10 mM	0.2993 mL	1.4965 mL	2.993 mL	5.9861 mL	7.4826 mL
50 mM	0.0599 mL	0.2993 mL	0.5986 mL	1.1972 mL	1.4965 mL
100 mM	0.0299 mL	0.1497 mL	0.2993 mL	0.5986 mL	0.7483 mL

CFN95179	Yuanhunine	104387-15-7	355.4	C₂₁H₂₅NO₄
CFN90196	Corydaline	518-69-4	369.44	C₂₂H₂₇NO₄
CFN90330	Dehydrocorydalin	30045-16-0	366.44	C₂₂H₂₄NO₄
CFN91411	Tetradehydrothalictrifoline	114073-47-1	350.4	C₂₁H₂₀NO₄
CFN90407	Dehydrocavidine	83218-34-2	348.4	C₂₁H₁₈NO₄
CFN90604	Dehydrocorydaline nitrate	13005-09-9	428.44	C₂₂H₂₄NO₄.NO₃
CFN90415	Worenine	38763-29-0	334.11	C₂₀H₁₆NO₄+
CFN95587	New compound 23	N/A	334.4	C₂₀H₁₆NO₄+
CFN91710	Corysamine chloride	11028-77-6	369.8	C₂₀H₁₆ClNO₄