Zederone | CAS:7727-79-9 | Manufacturer ChemFaces

Zederone

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $70.4 / In-stock
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Description:

Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries.

Targets:

TNF-α | Nrf2 | NADPH-oxidase | P450 (e.g. CYP17) | Antifection

In vivo:

Int J Toxicol. 2013 Nov-Dec;32(6):454-62.

Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice.[Pubmed: 24082031]

The present study aimed to investigate the hepatotoxicity of Zederone isolated from Curcuma elata in mice.
METHODS AND RESULTS:
Adult male mice were intraperitoneally injected with a single dose of Zederone (50-300 mg/kg body weight [BW]). Twenty-four hours after the injection, Zederone induced liver enlargement with scattered white foci over the organ. The medium lethal dose (LD₅₀) value at 24 hours of Zederone was approximately 223 mg/kg BW. Hepatic centrilobular necrosis with marked increases in plasma alanine transaminase activity and total bilirubin levels was observed. Zederone at a dose of 200 mg/kg BW markedly decreased the activity of superoxide dismutase and the hepatic glutathione content, whereas the activity of catalase was not altered. The compound at this dose also increased the messenger RNA (mRNA) expression of Cyp2b10 and Cyp3a11, which are the main drug-metabolizing enzymes in the liver. The mRNA expression of proinflammatory cytokine tumor necrosis factor α was increased. The nuclear factor-E2-related factor 2 protein, which is the transcription factor regulating the antioxidant gene expression, was decreased.
CONCLUSIONS:
The histopathology of massive hepatic centrilobular necrosis with an increase in the expression of cytochrome P450 (Cyp) suggests that the possible potentiation of Zederone-induced hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries.

Zederone Description

Source:	The rhizomes of Curcuma zedoaria
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Toxicol In Vitro. 2013 Sep;27(6):2005-12.

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.[Pubmed: 23850985]

Misclassification of Curcuma species (family Zingiberaceae) may lead to unwanted human exposure to Curcuma elata sesquiterpenes Zederone and germacrone which have caused hepatotoxicity and changes in CYP expression in laboratory animals.
METHODS AND RESULTS:
We investigated how these compounds interact with the human cytochrome P450 (CYP) system, in order to evaluate their potential for human liver toxicity and herb-drug interactions. We found that both sesquiterpenes (1-30 μM) greatly induced expression of CYP2B6 and CYP3A4 but not CYP1A2 mRNAs in human primary hepatocytes (HPHs). This induction profile correlated with activation of constitutive androstane and pregnane X receptors. Cytotoxicity was also observed in exposed HPHs. CYP inhibition studies with pooled human liver microsomes (HLMs) indicated that Zederone and germacrone moderately inhibited CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 μM. When Zederone was incubated with HLMs and NADPH, one di-epoxide metabolite was formed and by using glutathione trapping, five epoxide-derived conjugates were detected. Germacrone produced two oxidized metabolites and four glutathione conjugates.
CONCLUSIONS:
The results suggest that enzymes in HLMs convert sesquiterpenes into reactive, electrophilic compounds which may be causative for the reported liver injuries. These findings provide insight on the safety and drug-herb interactions of the Curcuma species.

Product Name	Zederone
Price:	$278 / 20mg
CAS No.:	7727-79-9
Catalog No.:	CFN92616
Molecular Formula:	C₁₅H₁₈O₃
Molecular Weight:	246.3 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The rhizomes of Curcuma zedoaria
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Antileukaemic Compound Library Sesquiterpenoids Compound Library TNF-α Inhibitor Library P450 (e.g. CYP17) Inhibitor Library Nrf2 Inhibitor Library NADPH-oxidase Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0601 mL	20.3004 mL	40.6009 mL	81.2018 mL	101.5022 mL
5 mM	0.812 mL	4.0601 mL	8.1202 mL	16.2404 mL	20.3004 mL
10 mM	0.406 mL	2.03 mL	4.0601 mL	8.1202 mL	10.1502 mL
50 mM	0.0812 mL	0.406 mL	0.812 mL	1.624 mL	2.03 mL
100 mM	0.0406 mL	0.203 mL	0.406 mL	0.812 mL	1.015 mL

CFN95214	1,2-Epoxy-10(14)-furanogermacren-6-one	383368-24-9	246.3	C₁₅H₁₈O₃
CFN95219	(1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one	1393342-06-7	260.3	C₁₆H₂₀O₃
CFN98175	Linderane	13476-25-0	260.28	C₁₅H₁₆O₄
CFN91936	Pseudoneolinderane	20082-45-5	260.29	C₁₅H₁₆O₄
CFN91911	Dihydropyrocurzerenone	59462-26-9	214.30	C₁₅H₁₈O
CFN96169	Pyrocurzerenone	20013-75-6	212.3	C₁₅H₁₆O
CFN96174	Dehydrochromolaenin	20013-76-7	210.3	C₁₅H₁₄O
CFN95220	2-Methoxyfuranoguaia-9-ene-8-one	88010-62-2	260.3	C₁₆H₂₀O₃
CFN95197	2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one	1809980-25-3	320.4	C₁₈H₂₄O₅
CFN98971	Isofuranodiene	57566-47-9	216.3	C₁₅H₂₀O