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alpha-Conidendrin
alpha-Conidendrin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name alpha-Conidendrin
Price:
CAS No.: 85699-62-3
Catalog No.: CFN97420
Molecular Formula: C20H20O6
Molecular Weight: 356.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The barks of Tsuga dumosa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
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Related Libraries
Biological Activity
Description: Reference standards.
In vitro:
J Med Chem. 2001 Jan 18;44(2):180-5.
Cytotoxic responses to aromatic ring and configurational variations in alpha-conidendrin, podophyllotoxin, and sikkimotoxin derivatives.[Pubmed: 11170627]
Derivatives of alpha-Conidendrin, podophyllotoxin, and sikkimotoxin were prepared to evaluate the cytotoxic contributions of C-4 configuration and pendant and fused arene substitutions.
METHODS AND RESULTS:
Dimethyl-alpha-conidendryl alcohol (5), 9-deoxypodophyllol (6), and 9-deoxysikkimol (17) were dehydrated to their respective oxolane derivatives 4, 3, and 9. Diols 5 and 6 were converted via oxabicyclo[3.2.1]octanols 10 and 14 to target oxolanes 8 and 7 where C-4 had been inverted relative to that in 3 and 4. Cytotoxicities of the five oxolanes were determined in two drug-sensitive human leukemia and two multidrug-resistant cell lines expressing P-glycoprotein or multidrug-resistance associated protein (MRP). Changing the pendant arene configuration or replacing a m-methoxy by hydrogen resulted in a 100-fold cytotoxicity loss. Replacing a methylenedioxy group in the fused arene by two methoxy substituents reduced cytotoxicity by 10-fold.
CONCLUSIONS:
Drug-resistant cell lines were equally resistant to compounds 3, 4, 8, and 9 indicating that these four compounds do not serve as substrates of the transport proteins P-glycoprotein and MRP.
alpha-Conidendrin Description
Source: The barks of Tsuga dumosa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

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doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8058 mL 14.0292 mL 28.0584 mL 56.1167 mL 70.1459 mL
5 mM 0.5612 mL 2.8058 mL 5.6117 mL 11.2233 mL 14.0292 mL
10 mM 0.2806 mL 1.4029 mL 2.8058 mL 5.6117 mL 7.0146 mL
50 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1223 mL 1.4029 mL
100 mM 0.0281 mL 0.1403 mL 0.2806 mL 0.5612 mL 0.7015 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 2004 Apr;67(4):697-9.
Alpha-conidendrin as a source for preparation of sikkimotoxin derivatives.[Pubmed: 15104508]

METHODS AND RESULTS:
Oxidation of alpha-Conidendrin (3) by Fremy's salt favored formation of an o-quinone (4) at the pendant aromatic ring as opposed to the fused aromatic ring. Quinone reduction and phenolic methylation, followed by lactone reduction, and subsequent oxidation by dichlorodicyanoquinone produced sikkimotoxin oxabicyclooctane (7), while oxidation with cupric sulfate/potassium persulfate gave sikkimotoxin dioxatricyclodecane (8).
CFN99168Podophyllotoxin518-28-5414.41C22H22O8
CFN91618Epipodophyllotoxin4375-07-9414.41C22H22O8
CFN91908Podophyllotoxin 4-O-glucoside16481-54-2576.55C28H32O13
CFN991284'-Demethylepipodophyllotoxin6559-91-7400.38C21H20O8
CFN99279Acetylepipodophyllotoxin1180-35-4456.5 C24H24O9
CFN91537Tetradehydropodophyllotoxin42123-27-3410.4C22H18O8
CFN95701Justicidin B17951-19-8364.4C21H16O6
CFN95712Justicidinoside C177912-23-1542.5C27H26O12
CFN91906Diphyllin22055-22-7380.35C21H16O7
CFN91907Diphyllin O-glucoside30021-77-3542.49C27H26O12
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