8-Hydroxy-5,7-dimethoxyflavanone | CAS:201230-40-2

8-Hydroxy-5,7-dimethoxyflavanone

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Description:

8-Hydroxy-5,7-dimethoxyflavanone represents a useful tumor-preventive phytochemical that triggers p53-driven G2/M cell cycle arrest and apoptosis.PDMF(8-Hydroxy-5,7-dimethoxyflavanone) as a new potent anti-allergic phytochemical useful for prevention of IgE-driven hypersensitivity reactions.8-hydroxy-5,7-dimethoxyflavanone has anti-inflammatory activity.

In vitro:

Cytotechnology . 2018 Jun;70(3):899-912.

A methoxyflavanone derivative from the Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma[Pubmed: 28710570]

Perilla frutescens is an Asian dietary herb consumed as an essential seasoning in Japanese cuisine as well as used for a Chinese medicine. Here, we report that a newly found methoxyflavanone derivative from P. frutescens (Perilla-derived methoxyflavanone, PDMF; 8-Hydroxy-5,7-dimethoxyflavanone) shows carcinostatic activity on human lung adenocarcinoma, A549. We found that treatment with PDMF significantly inhibited cell proliferation and decreased viability through induction of G2/M cell cycle arrest and apoptosis. The PDMF stimulation induces phosphorylation of tumor suppressor p53 on Ser15, and increases its protein amount in conjunction with up-regulation of downstream cyclin-dependent kinase inhibitor p21Cip1/Waf1 and proapoptotic caspases, caspase-9 and caspase-3. We also found that small interfering RNA knockdown of p53 completely abolished the PDMF-induced G2/M cell cycle arrest, and substantially abrogated its proapoptotic potency. These results suggest that PDMF represents a useful tumor-preventive phytochemical that triggers p53-driven G2/M cell cycle arrest and apoptosis.

Biochem Biophys Res Commun . 2017 Jan 29;483(1):674-679.

A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions[Pubmed: 27986566]

Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P. frutescens phytochemical that potently suppresses IgE-mediated type I hypersensitivity reactions. Structural analysis reveals that the purified anti-allergic compound (Perilla-derived methoxyflavanone, PDMF) is identified as 8-Hydroxy-5,7-dimethoxyflavanone. PDMF significantly inhibits IgE-mediated histamine release from RBL-2H3 rat basophilic leukemia cells as compared with those seen in known P. frutescens-derived anti-inflammatory polyphenols. We also show that oral administration of PDMF not only suppresses passive cutaneous anaphylaxis, but also prevents allergic rhinitis-like nasal symptoms in a murine model of Japanese cedar pollinosis. Mechanistically, PDMF negatively regulates Akt phosphorylation and intracellular Ca2+ influx, both of which are essential for mast cell secretory granule translocation and its exocytosis upon high-affinity IgE receptor (FcεRI) cross-linking. These results represent PDMF as a new potent anti-allergic phytochemical useful for prevention of IgE-driven hypersensitivity reactions.

In vivo:

Biochem Biophys Res Commun . 2017 Jan 29;483(1):674-679.

A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions[Pubmed: 27986566]

8-Hydroxy-5,7-dimethoxyflavanone Description

Source:	The herbs of Chloranthus spicatus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	8-Hydroxy-5,7-dimethoxyflavanone
Price:	$318 / 5mg
CAS No.:	201230-40-2
Catalog No.:	CFN95580
Molecular Formula:	C₁₇H₁₆O₅
Molecular Weight:	300.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Chloranthus spicatus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.33 mL	16.65 mL	33.3 mL	66.6001 mL	83.2501 mL
5 mM	0.666 mL	3.33 mL	6.66 mL	13.32 mL	16.65 mL
10 mM	0.333 mL	1.665 mL	3.33 mL	6.66 mL	8.325 mL
50 mM	0.0666 mL	0.333 mL	0.666 mL	1.332 mL	1.665 mL
100 mM	0.0333 mL	0.1665 mL	0.333 mL	0.666 mL	0.8325 mL

CFN99096	Pinocembrin 7-acetate	109592-60-1	298.3	C₁₇H₁₄O₅
CFN99211	Pinocembrin diacetate	111441-88-4	340.3	C₁₉H₁₆O₆
CFN98739	Pinostrobin	480-37-5	270.3	C₁₆H₁₄O₄
CFN98489	Alpinetin	36052-37-6	270.3	C₁₆H₁₄O₄
CFN92662	5,7-Dimethoxyflavanone	1036-72-2	284.3	C₁₇H₁₆O₄
CFN90899	(2R)-5,7-Dimethoxyflavanone	1277188-85-8	284.31	C₁₇H₁₆O₄
CFN93796	Dihydrobaicalein	35683-17-1	272.3	C₁₅H₁₂O₅
CFN92591	Dihydrooroxylin A	18956-18-8	286.3	C₁₆H₁₄O₅
CFN92422	Onysilin	73695-94-0	300.3	C₁₇H₁₆O₅
CFN99241	5-Hydroxy-7,8-dimethoxyflavanone	113981-49-0	300.3	C₁₇H₁₆O₅