alpha-Amyrin palmitate | CAS:22255-10-3

alpha-Amyrin palmitate

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Description:

alpha-Amyrin palmitate is antiarthritic in the adjuvant model of arthritis in rats. alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin (Ki=6 microM), it also shows weak cytotoxicity against the A2780 human ovarian cancer cell line.

Targets:

PKA

In vivo:

Drugs Exp Clin Res. 1994;20(1):1-5.

Effect of alpha-amyrin palmitate on adjuvant arthritis.[Pubmed: 7924889]

METHODS AND RESULTS:
alpha-Amyrin palmitate was synthesized and tested on adult male Wistar rats made arthritic by subplantar injection of complete Freund's adjuvant. When administered orally at 66 mg/kg BW every 48 h for 5 days from days 32 to 40 post-adjuvant and assessed on day 50, alpha-Amyrin palmitate returned the increases in serum hyaluronate and blood granulocytes toward non-arthritic levels and corrected the moderate anaemia of adjuvant arthritis. Histological examinations of the second and third proximal foot interphalangeal joints showed reduced synovial proliferation and invasion of joints and reduced leucocyte infiltration of bone marrow in alpha-Amyrin palmitate-treated rats. In addition, the drug prevented or reduced bone (subchondral or cortical) and cartilage (articular) destruction in arthritic rats.
CONCLUSIONS:
The results suggest that alpha-Amyrin palmitate is antiarthritic in the adjuvant model of arthritis in rats.

alpha-Amyrin palmitate Description

Source:	The herbs of Ficus tikoua
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Planta Med. 2000 Apr;66(3):206-10.

Inhibition of serine proteases by anti-inflammatory triterpenoids.[Pubmed: 10821043]

The lupane triterpenoid lupeol, the ursane triterpenoid alpha-amyrin and esters of these compounds are present in the bark of roots of Alstonia boonei (Apocynaceae) and have anti-inflammatory properties.
METHODS AND RESULTS:
alpha-Amyrin is a competitive inhibitor of bovine trypsin and chymotrypsin (Ki values 29 microM and 18 microM, respectively). Lupeol linoleate, lupeol palmitate and alpha-amyrin linoleate are non-competitive inhibitors of trypsin (Ki values 7 microM, 10 microM and 16 microM, respectively). alpha-Amyrin linoleate is also a non-competitive inhibitor of chymotrypsin (Ki value 28 microM). Lupeol is a competitive inhibitor of both trypsin and chymotrypsin (Ki values 22 and 8 microM, respectively). alpha-Amyrin palmitate is a potent non-competitive inhibitor of chymotrypsin (Ki 6 microM). Lupeol, alpha-amyrin and the palmitic and linoleic acid esters of these compounds are ineffective or very weak as inhibitors of porcine pancreatic elastase and of Lucilia cuprina and Helicoverpa punctigera leucine aminopeptidases.
CONCLUSIONS:
These hydrophobic triterpenoids represent further examples of anti-inflammatory triterpenoids that are PKA inhibitors as well as being selective protease inhibitors.obic triterpenoids represent further examples of anti-inflammatory triterpenoids that are PKA inhibitors as well as being selective protease inhibitors.

Product Name	alpha-Amyrin palmitate
Price:
CAS No.:	22255-10-3
Catalog No.:	CFN98210
Molecular Formula:	C₄₆H₈₀O₂
Molecular Weight:	665.1 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The herbs of Ficus tikoua
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Inhibitors Compound Library Cytotoxic Compound Library Anti-arthritic Compound Library Triterpenoids Compound Library PKA Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5035 mL	7.5177 mL	15.0353 mL	30.0707 mL	37.5883 mL
5 mM	0.3007 mL	1.5035 mL	3.0071 mL	6.0141 mL	7.5177 mL
10 mM	0.1504 mL	0.7518 mL	1.5035 mL	3.0071 mL	3.7588 mL
50 mM	0.0301 mL	0.1504 mL	0.3007 mL	0.6014 mL	0.7518 mL
100 mM	0.015 mL	0.0752 mL	0.1504 mL	0.3007 mL	0.3759 mL

CFN93111	Arnidiol	6750-30-7	440.7	C₃₀H₄₈O₂
CFN99808	Bauerenol acetate	17020-04-1	468.8	C₃₂H₅₂O₂
CFN98912	Uvaol	545-46-0	442.7	C₃₀H₅₀O₂
CFN99355	12-Ursene-3,16,22-triol	1242085-06-8	458.7	C₃₀H₅₀O₃
CFN89447	16alpha-Hydroxybauerenol	214351-30-1	442.71	C₃₀H₅₀O₂
CFN97423	alpha-Amyrin acetate	863-76-3	468.8	C₃₂H₅₂O₂
CFN98210	alpha-Amyrin palmitate	22255-10-3	665.1	C₄₆H₈₀O₂
CFN98689	Pseudotaraxasterol	464-98-2	426.7	C₃₀H₅₀O
CFN93020	Faradiol	20554-95-4	442.7	C₃₀H₅₀O₂
CFN99074	Taraxasterol	1059-14-9	426.7	C₃₀H₅₀O