beta-Rhamnocitrin | CAS:90-19-7 | Manufacturer ChemFaces

beta-Rhamnocitrin

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Description:

Beta-Rhamnocitrin is used as a 0.4% aq. soln. for photometric detn. of U (max 505 nm), Th, Fe.

In vivo:

Molecules . 2017 Aug 31;22(9):1441.

Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2[Pubmed: 28858248]

Abstract Rhamnetin (Rhm), 3-O-methylquercetin (3MQ), and Rhamnazin (Rhz) are methylated derivatives of quercetin commonly found in fruits and vegetables that possess antioxidant and anti-inflammatory properties. Phospholipase A2 (PLA2) displays several important roles during acute inflammation; therefore, this study aimed at investigating new compounds able to inhibit this enzyme, besides evaluating creatine kinase (CK) levels and citotoxicity. Methylated quercetins were compared with quercetin (Q) and were incubated with secretory PLA2 (sPLA2) from Bothrops jararacussu to determine their inhibitory activity. Cytotoxic studies were performed by using the J774 cell lineage incubated with quercertins. In vivo tests were performed with Swiss female mice to evaluate decreasing paw edema potential and compounds' CK levels. Structural modifications on sPLA2 were made with circular dichroism (CD). Despite Q and Rhz showing greater enzymatic inhibitory potential, high CK was observed. Rhm exhibited sPLA2 inhibitory potential, no toxicity and, remarkably, it decreased CK levels. The presence of 3OH on the C-ring of Rhm may contribute to both its anti-inflammatory and enzymatic inhibition of sPLA2, and the methylation of ring A may provide the increase in cell viability and low CK level induced by sPLA2. These results showed that Rhm can be a candidate as a natural compound for the development of new anti-inflammatory drugs. Keywords: Bothrops jararacussu; anti-inflammatory; methylated quercetins; phospholipase A2; rhamnetin.

beta-Rhamnocitrin Description

Source:	The branches of Rhamnus cathartica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	beta-Rhamnocitrin
Price:
CAS No.:	90-19-7
Catalog No.:	CFN92328
Molecular Formula:	C₁₆H₁₂O₇
Molecular Weight:	316.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The branches of Rhamnus cathartica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antibacterial Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1616 mL	15.8078 mL	31.6156 mL	63.2311 mL	79.0389 mL
5 mM	0.6323 mL	3.1616 mL	6.3231 mL	12.6462 mL	15.8078 mL
10 mM	0.3162 mL	1.5808 mL	3.1616 mL	6.3231 mL	7.9039 mL
50 mM	0.0632 mL	0.3162 mL	0.6323 mL	1.2646 mL	1.5808 mL
100 mM	0.0316 mL	0.1581 mL	0.3162 mL	0.6323 mL	0.7904 mL

CFN98429	Quercetin 3,4'-dimethyl ether	33429-83-3	330.3	C₁₇H₁₄O₇
CFN98876	Ombuin	529-40-8	330.3	C₁₇H₁₄O₇
CFN96157	Ayanin	572-32-7	344.3	C₁₈H₁₆O₇
CFN90433	Centaureidin	17313-52-9	360.31	C₁₈H₁₆O₈
CFN89530	Axillarin	5188-73-8	346.28	C₁₇H₁₄O₈
CFN98172	Vitexicarpin	479-91-4	374.34	C₁₉H₁₈O₈
CFN98735	Isorhamnetin	480-19-3	316.3	C₁₆H₁₂O₇
CFN89506	Quercetin 3,3'-dimethyl ether	4382-17-6	330.28	C₁₇H₁₄O₇
CFN91556	Quercetin 3,5,3'-trimethyl ether	13459-09-1	344.3	C₁₈H₁₆O₇
CFN70409	Rhamnazin	552-54-5	330.3	C₁₇H₁₄O₇