Hot Products
| Catalog No. | Information |
| CFN60045 | Olaparib (AZD2281) Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations. |
| CFN90395 | Olaquindox Olaquindox, as one of the antimicrobial growth accelerants, is usually used in livestock production to improve feed efficiency. Olaquindox induces apoptosis of HepG2 cells through a caspase-9 dependent mitochondrial pathway, might be suppressed through p38 MAPK and ROS-JNK pathways; it induces autophagy in HepG2 cells is upregulated by Beclin 1 but downregulated by ROS-dependent JNK.Olaquindox has genotoxic activity. |
| CFN70276 | Oleacein Oleacein has antioxidant, anti-metastatic, anticancer, and anti-inflammatory activities, it inhibits STAT3, activates the apoptotic machinery. Oleacein can be used as an adjuvant to improve insulin sensitivity in humans, and it could play a potential role in the prevention of inflammatory disease related to atherosclerosis. |
| CFN98871 | Olean-12-ene-3,11-diol Reference standards. |
| CFN98693 | Oleandrin Oleandrin has anticarcinogenic, anti-inflammatory, and growth-modulatory effects , which may thus be partially ascribed to the inhibition of activation of NF-κB and AP-1 and potentiation of apoptosis; it has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.Oleandrin inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM. |
| CFN98800 | Oleanolic acid Oleanolic acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor, anti-inflammatory, antioxidant, and antiviral properties. Oleanolic acid exhibits anti-HCV activity at least partly through suppressing HCV NS5B RdRp activity as a noncompetitive inhibitor; it induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways; can be employed as a lead in the development of potent NO inhibitors. Oleanolic acid supplement ameliorates fructose-induced Adipo-IR in rats via the IRS-1/phosphatidylinositol 3-kinase/Akt pathway. |
| CFN90884 | Oleaside A Oleaside A is a natural product from Nerium oleander. |
| CFN94800 | Oleic acid Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. It shows larvicidal effects against fourth instar larvae of Aedes aegypti L. , Anopheles stephensi Liston , and Culex quinquefasciatus Say. |
| CFN70331 | Oleocanthal Oleocanthal as anti-inflammatory therapeutic agent, it shows inhibition of MIP-1α and IL-6 in J774 macrophages and in ATDC5 chondrocytes. Oleocanthal and its derivatives can decrease lipopolysaccharide-induced NOS2 synthesis in chondrocytes without significantly affecting cell viability at lower concentrations.Oleocanthal abrogates fibrillization of tau by locking tau into the naturally unfolded state. |
| CFN99838 | Oleoside Oleacein is a strong Angiotensin Converting Enzyme (ACE)-inhibitor (IC50 = 26 uM). |
